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Protein Alignment Ir7a and GRIN2B

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	631	Identity:	111/631 - (17%)
Similarity:	211/631 - (33%)	Gaps:	178/631 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 VPASFVVFLVNSAQAFNTLGFHFTDIHSTREFNFLILLTHRMSSRAERLQVLRDISRTCVRFHTS 156
            |||.|...|::.:......|.      ..|..:.:.::|...|........:.:...:|...|
Human   269 VPAEFPTGLISVSYDEWDYGL------PARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTH-- 325

  Fly   157 NVILLTEKRDGVVLVYAYRLLNMDCDLSVNLE--LIDIYKNGLFRHG-------HEARSFNRVLS 212
                  |||     :|...:||... ::|..|  .:...::|...|.       ::.|.:.||..
Human   326 ------EKR-----IYQSNMLNRYL-INVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGK 378

  Fly   213 LSGCPLQVSWYPLP----------------------PFVSFIGNSSDP----------------- 238
            .....||:.:|..|                      |||  |..|.||
Human   379 WKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFV--IVESVDPLSGTCMRNTVPCQKRIV 441

  Fly   239 ------EERAQIWR-LTGIDGELIKLLASIFDFRILLEEPCNKCLSPDIKDDCSGCFDQVIISNS 296
                  ||...|.: ..|...:::|.::....|...|....|......|....:|...:|::..:
Human   442 TENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRA 506

  Fly   297 SILIGAMSGSHQHRSHFSFTSSYHQSSLVFIMHMSSQFGAVAQLAV--PFTVIVW-----LALVV 354
            .:.:|:::.:.:......|:..:.::.:..::..|:  |.|:..|.  ||:..||     :.|:|
Human   507 YMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSN--GTVSPSAFLEPFSADVWVMMFVMLLIV 569

  Fly   355 SSLLLVLVLWMR----NRLVC------GRSDLASHALQVLTTLMGNPLEARSLPRSSRLRILYAG 409
            |::.:.:..:..    ||.:.      |.|.....|:.:|..|:.|.......|:.:..:|:.:.
Human   570 SAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSV 634

  Fly   410 WLLLVLVLRVVYQGKLF-----------------------DSFRLPYH-KPLPTEISEL-IRSNY 449
            |....::....|...|.                       :.|..|:. ..:|...:|. ||:||
Human   635 WAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNY 699

  Fly   450 T-------LINQEYLDYYPRELTVLTRNGSKDRF-------DYIQGLGKEGKFTTT---SLIATM 497
            .       ..||..:|    :..:..:.|..|.|       :|:.|..:..|..|.   .:.|:.
Human   700 AEMHAYMGKFNQRGVD----DALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFAST 760

  Fly   498 EYYNMMHWSTSRLTHIKEHIFLYQMVIYLRRHSLLKFAFDRKIKQLLSAGIIGYFVREFDA---- 558
            .|                       .|.:::.|..|...|..|.||...|    .:.|.:|
Human   761 GY-----------------------GIAIQKDSGWKRQVDLAILQLFGDG----EMEELEALWLT 798

  Fly   559 --CQYRKPFEEDYEVTPIPLDSFCGLYYISLIWLSAAVVAFILELL 602
              |...|   .:...:.:.:|:..|::|:....::.:::.||.|.|
Human   799 GICHNEK---NEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHL 841

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.