Protein Alignment Ir7a and GRIA3

DIOPT Version :9

• Sequence 1: NP_572406.1
• Gene: Ir7a / 31686
• FlyBaseID: FBgn0029961
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Alignment Length: 420
• Identity: 78/420 - (18%)
• Similarity: 133/420 - (31%)
• Gaps: 140/420 - (33%)

  Fly    75 SVGSEMALRTFQKPPAEVPASFVVFLVNSAQAFNT------LGFHFTDIHSTREFNFLILLTHRM 133
            |:|......|.|:..|   ..|.|.|.|:.|  ||      |.:|...:.|:..|:    :|:..
Human    35 SIGGLFMRNTVQEHSA---FRFAVQLYNTNQ--NTTEKPFHLNYHVDHLDSSNSFS----VTNAF 90

  Fly   134 SSRAER----------LQVLRDISRTCVRFHTSNVILLTEKRDGVVLVYAYRLLNMDCDLSVNLE 188
            .|:..|          ...:..::..|...|||.|.........|..|...|.......||
Human    91 CSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILS---- 151

  Fly   189 LIDIYKNGLFRHGHEA-RSFNRVLSLSGCPLQVSWYPLPPFVSFIGNSSDPEERAQIWRLTGIDG 252
            |:..||...|.:.::. |.|:.:.::....:|.:|...   ...:||..|.:|
Human   152 LLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVT---ARSVGNIKDVQE------------ 201

  Fly   253 ELIKLLASIFDFRILLEEPCNKCLSPDIKDDC-----SGCFDQVIISNSSILIGAMSGSHQHRSH 312
                       ||.::|| .::........||     :...:||:|          .|.|
Human   202 -----------FRRIIEE-MDRRQEKRYLIDCEVERINTILEQVVI----------LGKH----- 239

  Fly   313 FSFTSSYHQSSLVFIMHMSSQFGAVAQLAVPFTVIVWLALVVSSLLLVLVLWMRNRLVCGRSDLA 377
               :..||        :|.:..|        ||.|                 :..|::.|.:::.
Human   240 ---SRGYH--------YMLANLG--------FTDI-----------------LLERVMHGGANIT 268

  Fly   378 SHALQVLTTLMGNPLEARSLPRSSRLRILYAGWLLLVLVLRVVYQGKLFDSFRLPYHKPLPTEIS 442
              ..|::..  .||:..:.:.|          |:.|             |....|..|..|.:.:
Human   269 --GFQIVNN--ENPMVQQFIQR----------WVRL-------------DEREFPEAKNAPLKYT 306

  Fly   443 ELIRSNYTLINQEYLDYYPRELTVLTRNGS 472
            ..:..:..|:..|...|..|:...::|.||
Human   307 SALTHDAILVIAEAFRYLRRQRVDVSRRGS 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	78/420 (19%)
		PBP2_iGluR_AMPA	422..805	CDD:270433
		Glutamate binding. /evidence=ECO:0000250	508..510
		Glutamate binding. /evidence=ECO:0000250	686..687

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900