Protein Alignment Ir7a and GRIA2

DIOPT Version :9

• Sequence 1: NP_572406.1
• Gene: Ir7a / 31686
• FlyBaseID: FBgn0029961
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 116/607 - (19%)
• Similarity: 210/607 - (34%)
• Gaps: 143/607 - (23%)

  Fly    89 PAEVPASFVVFLVNSAQAFNTLGFHFTDIHSTREFNFLILLTHRMSSRAER----------LQVL 143
            |......:..|.|...| |:|..|..|......|......:|:...|:..|          .:.:
Human    34 PRGADQEYSAFRVGMVQ-FSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSV 97

  Fly   144 RDISRTCVRFHTSNVILLTEKRDGVVLVYAYRLLNMDCDL-SVNLELIDIYKNGLFRHGHEA-RS 206
            ..|:..|...|.| .|..:...||   .:.: ::.|..|| ...|.||:.|:...|.:.::: |.
Human    98 NTITSFCGTLHVS-FITPSFPTDG---THPF-VIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRG 157

  Fly   207 FNRVLSLSGCPLQVSWYPLPPFVSFIGNSSDPEERAQIWRLTGIDGELIKLLASIFDFRILLEEP 271
            .:.:.::.....:..|......|..|.|    :::.:::|....|.||.|      :.|::|:
Human   158 LSTLQAVLDSAAEKKWQVTAINVGNINN----DKKDEMYRSLFQDLELKK------ERRVILD-- 210

  Fly   272 CNKCLSPDIKDDCSGCFDQVIISNSSILIGAMSGSHQHRSHFSFT--------------SSY--- 319
            |.       :|..:...||||.....:     .|.|...::..||              |.:
Human   211 CE-------RDKVNDIVDQVITIGKHV-----KGYHYIIANLGFTDGDLLKIQFGGANVSGFQIV 263

  Fly   320 -HQSSLV--FIMHMSSQFGAVAQLAVP---FTVIVWLALVVSSLLLVLVLWMRN----RLVCGRS 374
             :..|||  ||    .::..:.:...|   .|.|.:.:.:....:.|:....||    |:...|.
Human   264 DYDDSLVSKFI----ERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR 324

  Fly   375 DLASHAL------------------QV-LTTLMGN------------PLEARSLPRSSRLRILYA 408
            ..|...|                  || :..|.||            .:....|..:...:|.|
Human   325 GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGY- 388

  Fly   409 GWL---LLVLVLRVVYQGKLFDSFRLPYHKPLPTEISE----LIRSNYTLI--NQEYLDYYPREL 464
             |.   .:|:.|..:..|.  |:..|.....:.|.|.|    :::.|:.::  |:.|..|.....
Human   389 -WSEVDKMVVTLTELPSGN--DTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLA 450

  Fly   465 TVLTRNGSKDRFDYIQGLGKEGKFTTTSLIATMEYYNMMHWSTSRLTHIKEHIFLYQMVIYLRRH 529
            ..:.::..   |.|...:..:||:....  |..:.:|.|   ...|.:.|..|.:..:.|.|.|.
Human   451 AEIAKHCG---FKYKLTIVGDGKYGARD--ADTKIWNGM---VGELVYGKADIAIAPLTITLVRE 507

  Fly   530 SLLKFAFDRKIKQLLSAGIIGYFVREFDACQYRKPFEEDYEVTPIPLDSFCGLYYISLI--WLSA 592
            .::.|:     |..:|.||         :...:||.:....|... ||......::.::  ::..
Human   508 EVIDFS-----KPFMSLGI---------SIMIKKPQKSKPGVFSF-LDPLAYEIWMCIVFAYIGV 557

  Fly   593 AVVAFILELLSQRIVWLRRIFE 614
            :||.|::...|. ..|....||
Human   558 SVVLFLVSRFSP-YEWHTEEFE 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	75/399 (19%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	37/190 (19%)
		Glutamate binding	499..501		0/1 (0%)
		Glutamate binding	675..676
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810