DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7a and Grin2d

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	96/469 - (20%)
Similarity:	168/469 - (35%)	Gaps:	118/469 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 CPLQVSWYPLPPFVSFIGNSSDPEERAQIWRLTGIDGELIKLLASIFDFRILLEEPCNKCLSPDI 280
            |..|::....||     .::..||:|.    ..|...:::|.||....|...|....|......|
  Rat   459 CRSQLNRTHSPP-----PDAPRPEKRC----CKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKI 514

  Fly   281 KDDCSGCFDQVIISNSSILIGAMSGSHQHRSHFSFTSSYHQSSLVFIMHMS------SQFGAVAQ 339
            ....:|...:|....:.:.||:::.:.:......|:..:.::.:..::..|      |.|.|.|.
  Rat   515 DGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAW 579

  Fly   340 LA-----VPFTVIVWLALVVSSLLLVLV----------LWMRNRLVCGRSDLAS-----HALQVL 384
            |.     .|::..||:.:.|..|.:|.|          :.....|..|:....|     .::.:|
  Rat   580 LTPPMSPEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLL 644

  Fly   385 TTLMGN---PLEARSLPRSSRLRILYAGWLLLVLVLRVVY---------QGKLFDS--------F 429
            ..|:.|   |:|.   ||.:..:|:...|....::....|         |.:..|:        |
  Rat   645 WALVFNNSVPVEN---PRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKF 706

  Fly   430 RLPYHKPLPTEISEL--------IRSNYTLINQEYLDY-YPRELTVLT--RNGSKDRFDY----- 478
            :.|..:..|.:...:        |||||..::...:.| .||....||  :.|..|.|.|
  Rat   707 QRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVL 771

  Fly   479 -IQGLGKEG-KFTTT---SLIATMEYYNMMH----WSTSRLTHIKEHIFLYQMVIYLRRHSLLKF 534
             ......|| |..|.   .:.||..|...:|    |        |..|.|          :||:|
  Rat   772 NYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRW--------KRPIDL----------ALLQF 818

  Fly   535 AFDRKIKQLLSAGIIGYFVREFDACQYRKPFEEDYEV--TPIPLDSFCGLYYISLIWLSAAVVAF 597
            ..|.:|:.|....:.|       .|.     .:..||  :.:.:|:..|::|:.|:.:..:::.|
  Rat   819 LGDDEIEMLERLWLSG-------ICH-----NDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVF 871

  Fly   598 ILELLSQRIVWLRR 611
            ..|.|   :.|..|
  Rat   872 AWEHL---VYWRLR 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	85/420 (20%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810