DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7a and Grin2c

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	423	Identity:	79/423 - (18%)
Similarity:	154/423 - (36%)	Gaps:	102/423 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 ELIKLLASIFDFRILLEEPCNKCLSPDIKDDCSGCFDQVIISNSSILIGAMSGSHQHRSHFSFTS 317
            :::|.||.:..|...|....|......::...:|...:|....:.:.||:::.:.:......|:.
  Rat   473 DILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSV 537

  Fly   318 SYHQSSLVFIMHMSSQFGAVAQLAV--PFTVIVWLALVVSSLLLV-LVLWM-------------- 365
            .:.::.:..::..|:  |.|:..|.  |::..||:.:.|..|.:| :.::|
  Rat   538 PFVETGISVMVSRSN--GTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLT 600

  Fly   366 RNRLVCGRSDLASHALQVLTTLMGN---PLEARSLPRSSRLRILYAGWLLLVLVLRVVY------ 421
            :.:...|.|.....::.:|..|:.|   |:|.   ||.:..:|:...|....::....|
  Rat   601 KGKKPGGPSFTIGKSVWLLWALVFNNSVPIEN---PRGTTSKIMVLVWAFFAVIFLASYTANLAA 662

  Fly   422 ---QGKLFDS--------FRLPYHKPLPTEISEL--------IRSNY------------------ 449
               |.:..|:        |:.|..:..|.....:        |||||
  Rat   663 FMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDA 727

  Fly   450 -TLINQEYLDYYPRELTVLTRNGSKDRFDYIQGLGKEGKFTTTSLIATMEYYNMMHWSTSRLTHI 513
             |.:....||.:..:..||.....||....:..:|....|.||.....|:  ...||
  Rat   728 LTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQ--KDSHW-------- 782

  Fly   514 KEHIFLYQMVIYLRRHSLLKFAFDRKIKQLLSAGIIGYFVREFDACQYRKPFEEDYEVTPIPLDS 578
            |..|.|          :||:...|.:.::|.:..:.|       .||..|   .:...:.:.:|:
  Rat   783 KRAIDL----------ALLQLLGDGETQKLETVWLSG-------ICQNEK---NEVMSSKLDIDN 827

  Fly   579 FCGLYYISLIWLSAAVVAFILELLSQRIVWLRR 611
            ..|::|:.|:.:..|::.|..|.|   :.|..|
  Rat   828 MAGVFYMLLVAMGLALLVFAWEHL---VYWKLR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	67/371 (18%)
		NMDAR2_C	850..>925	CDD:402274	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810