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Protein Alignment Ir7a and Grin2a

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	685	Identity:	121/685 - (17%)
Similarity:	239/685 - (34%)	Gaps:	184/685 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LTQDAEHRDERQEQLMTIILRSVGSEMALRTFQKPPAEVPASFVVFLVNSAQAFNTLGFHF---- 114
            :|.|....|.:.:    :.|:.:.|.:.|....|..|       |.:::.|::....|:.|
  Rat   204 ITLDTSFEDAKTQ----VQLKKIHSSVILLYCSKDEA-------VLILSEARSLGLTGYDFFWIV 257

  Fly   115 -------TDIHSTREF---------------------NFLILLTHRMSSRAERLQVLRDISRTC- 150
                   |:: ..:||                     :.|.:||...||..|:...:.:...:|
  Rat   258 PSLVSGNTEL-IPKEFPSGLISVSYDDWDYSLEARVRDGLGILTTAASSMLEKFSYIPEAKASCY 321

  Fly   151 -------VRFHTSNVILLTEKRDGVVLVY---AYR--------LLNMDCDLSVNLELIDIYKNGL 197
                   ...||.:..::....||..|.:   .|:        :||.|.:    .|.:..::|..
  Rat   322 GQAEKPETPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDRE----WEKVGKWENQT 382

  Fly   198 FRHGHEARSFNRVLSLSGCP-----LQVSWYPLPPFV--------------------SFIGNSSD 237
            ....|..  :.|..|.|.|.     |.:......|||                    .|:..::.
  Rat   383 LSLRHAV--WPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNS 445

  Fly   238 PEERAQIWR-LTGIDGELIKLLASIFDFRILLEEPCNKCLSPDIKDDCSGCFDQVIISNSSILIG 301
            ..|...:.: ..|...:::|.|:....|...|....|......:.:..:|...:|:...:.:.:|
  Rat   446 TNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVG 510

  Fly   302 AMSGSHQHRSHFSFTSSYHQSSLVFIMHMSSQFGAVAQLAV--PFTVIVW-----LALVVSSLLL 359
            :::.:.:......|:..:.::.:..::..|:  |.|:..|.  ||:..||     :.|:||::.:
  Rat   511 SLTINEERSEVVDFSVPFVETGISVMVSRSN--GTVSPSAFLEPFSASVWVMMFVMLLIVSAIAV 573

  Fly   360 VL------VLWMRN----RLVCGRSDLASHALQVLTTLMGNPLEARSLPRSSRLRILYAGWLLLV 414
            .:      |.:.||    :...|.|.....|:.:|..|:.|.......|:.:..:|:.:.|....
  Rat   574 FVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFA 638

  Fly   415 LVLRVVYQGKLF-----------------DSFRLP--YHKP-----LPTEISEL-IRSNYTLINQ 454
            ::....|...|.                 ..|:.|  |..|     :|...:|. ||:||..::|
  Rat   639 VIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQ 703

  Fly   455 EYLDYYPR---ELTVLTRNGSKDRF-------DYIQGLGKEGKFTTTS---LIATMEYYNMMH-- 504
            ....:..|   :..|..:.|..|.|       :|..|..:..|..|..   :.||..|...:.
  Rat   704 YMTRFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKG 768

  Fly   505 --WSTSRLTHIKEHIFLYQMVIYLRRHSLLKFAFDRKIKQLLSAGIIGYFVREFDACQYRKPFEE 567
              |        |..|.|          :||:|..|.::::|.:..:.|       .|...|   .
  Rat   769 SPW--------KRQIDL----------ALLQFVGDGEMEELETLWLTG-------ICHNEK---N 805

  Fly   568 DYEVTPIPLDSFCGLYYISLIWLSAAVVAFILELL 602
            :...:.:.:|:..|::|:....::.:::.||.|.|
  Rat   806 EVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL 840

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.