DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7a and Grin3a

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	425	Identity:	84/425 - (19%)
Similarity:	140/425 - (32%)	Gaps:	123/425 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 LLEEPCNKCLSPDIKDDCSGCFDQVIISNSSI----------LIG-AMSGS----------HQHR 310
            |||:     |:.|:..|    ||..|:.:...          |:| .:||:          :..|
Mouse   583 LLEQ-----LAEDMNFD----FDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTAR 638

  Fly   311 SH-FSFTSSYHQSSLVFIMHMSSQFGAVAQLAVPFTVIVWL----ALVVSSLLLVLVLWM----- 365
            |. ..|||.:..:||..::........:.....|....:||    ||.::::.|.|..|.
Mouse   639 SQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGM 703

  Fly   366 ----RNRLVCGRSDLASHALQVLTTLMGNPLEARSLPRSSRLRILYAGW--------------LL 412
                |||   .:....|.||.|...|:.....|...|:....|.|...|              |.
Mouse   704 TPKGRNR---NKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLA 765

  Fly   413 LVLVLRVVY---------------QGKLFDSFRLPYHKPLPTEISELIRSNYTLINQ-------- 454
            .|:|...:|               ||..|.:.|       .:...:.:|.::..:::
Mouse   766 AVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVR-------ESSAEDYVRQSFPEMHEYMRRYNVP 823

  Fly   455 ------EYLDYYPRELTVLTRNGSKDRFDYIQGLGKEGKFTTTSLIATMEYYNMMHWSTSRLT-H 512
                  :||...|.:|.....:  |...||...:..:.|..|......:|.|.:.....|.|| :
Mouse   824 ATPDGVQYLKNDPEKLDAFIMD--KALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSN 886

  Fly   513 IKEHIFLYQMVIYLRRHSLLKFAFDRKIKQLLSAGIIGYFVREFDACQYRKPFEEDYEVTPIPLD 577
            |.|.|..|      :.|..:....|:..|      ::....|.|...          |...:.:.
Mouse   887 ISELISQY------KSHGFMDVLHDKWYK------VVPCGKRSFAVT----------ETLQMGIK 929

  Fly   578 SFCGLYYISLIWLSAAVVAFILELLSQRIVWLRRI 612
            .|.||:.:..|....:::..|.|.:..|:: |.||
Mouse   930 HFSGLFVLLCIGFGLSILTTIGEHIVYRLL-LPRI 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	70/351 (20%)
		Lig_chan	676..942	CDD:278489	57/299 (19%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		5/14 (36%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900