DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7a and Grin3a

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	86/452 - (19%)
Similarity:	147/452 - (32%)	Gaps:	121/452 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 LTGIDGELIKLLASIFDFRILLEEPCNKC-------LSPDIKDDCSGCFDQVIISNSSI------ 298
            :|.....|.:|.:|:......:.....||       |...:.:|.:..||..|:.:...
  Rat   547 MTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNG 611

  Fly   299 ----LIG-AMSGS----------HQHRSH-FSFTSSYHQSSLVFIMHMSSQFGAVAQLAVPFTVI 347
                |:| .:||:          :..||. ..|||.:..:||..::........:.....|....
  Rat   612 HWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWT 676

  Fly   348 VWL----ALVVSSLLLVLVLWM---------RNRLVCGRSDLASHALQVLTTLMGNPLEARSLPR 399
            :||    ||.::::.|.|..|.         |||   .:....|.||.|...|:.....|...|:
  Rat   677 MWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNR---NKVFSFSSALNVCYALLFGRTAAIKPPK 738

  Fly   400 SSRLRILYAGW--------------LLLVLVLRVVY---------------QGKLFDSFRLPYHK 435
            ....|.|...|              |..|:|...:|               ||..|.:.|
  Rat   739 CWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVR----- 798

  Fly   436 PLPTEISELIRSNYTLINQ--------------EYLDYYPRELTVLTRNGSKDRFDYIQGLGKEG 486
              .:...:.:|.::..:::              :||...|.:|.....:  |...||...:..:.
  Rat   799 --ESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMD--KALLDYEVSIDADC 859

  Fly   487 KFTTTSLIATMEYYNMMHWSTSRLT-HIKEHIFLYQMVIYLRRHSLLKFAFDRKIKQLLSAGIIG 550
            |..|......:|.|.:.....|.|| :|.|.|..|      :.|..:....|:..|      ::.
  Rat   860 KLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQY------KSHGFMDVLHDKWYK------VVP 912

  Fly   551 YFVREFDACQYRKPFEEDYEVTPIPLDSFCGLYYISLIWLSAAVVAFILELLSQRIVWLRRI 612
            ...|.|...          |...:.:..|.||:.:..|....:::..|.|.:..|:: |.||
  Rat   913 CGKRSFAVT----------ETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLL-LPRI 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	72/378 (19%)
		Lig_chan	676..942	CDD:278489	57/299 (19%)
		PPP2CB binding site	951..987		5/14 (36%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900