DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7a and gria3a

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	677	Identity:	129/677 - (19%)
Similarity:	208/677 - (30%)	Gaps:	262/677 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FVVFLVNSAQAFNTLGFHFT----DIHSTREFNFLILLTHRMSSRAER----------LQVLRDI 146
            |.|.|.|:.|......||..    ::.|:..|:    :||...|:..|          .:.:..:
Zfish    46 FAVQLYNTNQNITEKPFHLNYNVDNLESSNSFS----VTHAFCSQFSRGVYAIFGFYDRRSMNTL 106

  Fly   147 SRTCVRFHTSNVILLTEKRDGVVLVYAYRLLNMDCDL-SVNLELIDIYKNGLFRHGHEA-RSFNR 209
            :..|...|||.:.........|..|     |.|...| ...|.|:..||...|.:.::. |.|:.
Zfish   107 TSFCGALHTSFITPSFPTDTDVQFV-----LQMRPSLRGALLSLLAHYKWEKFVYLYDTDRGFSI 166

  Fly   210 VLSLSGCPLQVSWYPLPPFVSFIGNSSDPEERAQIWRLTGIDGELIKLLASIFDFRILLEEPCNK 274
            :.::....:..:|...   ...:||..||                       .::|.::|| .::
Zfish   167 LQAIMESAVMNNWQVT---ARSVGNIVDP-----------------------LEYRRIIEE-MDR 204

  Fly   275 CLSPDIKDDC-----SGCFDQVIISNSSILIGAMSGSHQHRSHFSFTSSYHQSSLVFIMHMSSQF 334
            ........||     :...:||:|:..:     ..|.|...::..||:          |.:...|
Zfish   205 RQEKRFLIDCEVERINSILEQVVIAGKN-----SRGYHYILANLGFTN----------MSLDKVF 254

  Fly   335 GAVA-----QLAVPFTVIV------W-------------------LALVVSSLLLVLVLW---MR 366
            ...|     |:..|.:.||      |                   .||...::|::...:   .|
Zfish   255 SGGANITGFQIINPDSPIVQQFLQRWERLDEREFPESRSSPLKYTSALTHDAILVIAEAFRYLRR 319

  Fly   367 NRLVCGRSDLASHALQVLTTLMGNPLEARSLPRSSRLRILYAGWLLLVLVLRVVYQGKL----FD 427
            .|:...|...|...|       .||    ::|.|..:.|..|  |.:|.|     ||..    ||
Zfish   320 QRVDISRRGSAGDCL-------ANP----AVPWSQGIDIERA--LKMVQV-----QGMTGNIQFD 366

  Fly   428 SFRLPYHKPLPTEISELIRSNYTL-----------------------------INQEYLDYYPRE 463
            ||..              |||||:                             :..|......|.
Zfish   367 SFGR--------------RSNYTVDVYEMKPGGARKIGYWNEFEKFVYIVEQQVTNESSSVENRT 417

  Fly   464 LTVLT----------RN----GSKDRFD-YIQGLGKE-----GKFTTTSLIATMEY--------- 499
            :.|.|          ||    ...||:: |...|..|     |.....|::|..:|
Zfish   418 IVVTTIMEAPYVMYKRNYMQLEGNDRYEGYCVDLASEIAKHVGIKYKLSIVADGKYGARDPETKT 482

  Fly   500 YNMMHWSTSRLTHIKEHIFLYQMVIYLRRHSLLKFAFDRKIKQLLSAGI---------------- 548
            :|.|   ...|.:.:..|.:..:.|.|.|..::.|:     |..:|.||
Zfish   483 WNGM---VGELVYGRADIAVAPLTITLVREEVIDFS-----KPFMSLGISIMIKKPQKSKPGVFS 539

  Fly   549 -----------------IGYFVREFDACQYRKPFE---------EDYEVTPIPLDSFCGLYYISL 587
                             ||..|..|...:: .|:|         :|.:..|.|.:.| |::  :.
Zfish   540 FLDPLAYEIWMCIVFAYIGVSVVLFLVSRF-SPYEWHLDDNEETKDPQTPPDPPNDF-GIF--NS 600

  Fly   588 IWLSAAVVAFILE-------LLSQRIV 607
            :|.|..  ||:.:       .||.|||
Zfish   601 LWFSLG--AFMQQGCDISPRSLSGRIV 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382	82/435 (19%)
		ANF_receptor	39..382	CDD:279440	82/418 (20%)
		PBP2_iGluR_AMPA	415..797	CDD:270433	46/225 (20%)
		Lig_chan	547..810	CDD:278489	20/85 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810