DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7a and Grin2d

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_036008580.1	Gene:	Grin2d / 14814	MGIID:	95823	Length:	1345	Species:	Mus musculus

Alignment Length:	723	Identity:	143/723 - (19%)
Similarity:	246/723 - (34%)	Gaps:	216/723 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HLWLLMGLRSLAMGALH-PPQPEAM---TPLVAAALEI--------LAEQVSPSQSTLA------ 50
            ::|.::|.:....|... |.:|..:   .||.|....:        ||.:|:...:.:|
Mouse   272 YVWFMVGPQLAGGGGSGVPGEPLLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQAL 336

  Fly    51 ------VMDLTQD--AEHRDERQEQLMTIILRSVGSEMALRTFQKPPAEVPASFVVFLVNSAQAF 107
                  :.:|..|  |::|..|.|.|....:.                       :...|...:|
Mouse   337 LRDYGFLPELGHDCRAQNRTHRGESLHRYFMN-----------------------ITWDNRDYSF 378

  Fly   108 NTLGF----HFTDIHSTREFNFLIL---------LTHRMSSRAER-LQVLRDISRTCVRFHTSNV 158
            |..||    ....|..||:..:.::         |.:.:.||..| ||.:.|         |.::
Mouse   379 NEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDD---------TQHL 434

  Fly   159 ILLT-EKRDGVVLVYAYRLLNMDCDLSVNLELIDIYKNGLFRHGHEARS-FNRVLSLSGCPLQVS 221
            .:.| |:|..|:                 :|..|.......|.....|| .||..||      |:
Mouse   435 TVATLEERPFVI-----------------VEPADPISGTCIRDSVPCRSQLNRTHSL------VA 476

  Fly   222 WYPLPPFVSFIGNSSDPEERAQIWRLTGIDGELIKLLASIFDFRILLEEPCNKCLSPDIKDDCSG 286
            ....||      ::..||:|.    ..|...:::|.||....|...|....|......|....:|
Mouse   477 PRSPPP------DAPRPEKRC----CKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNG 531

  Fly   287 CFDQVIISNSSILIGAMSGSHQHRSHFSFTSSYHQSSLVFIMHMS------SQFGAVAQL----- 340
            ...:|....:.:.||:::.:.:......|:..:.::.:..::..|      |.|.|.|.|
Mouse   532 MIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWLMPPMS 596

  Fly   341 AVPFTVIVWLALVVSSLLLVLV----------LWMRNRLVCGRSDLAS-----HALQVLTTLMGN 390
            ..|::..||:.:.|..|.:|.|          :.....|..|:....|     .::.:|..|:.|
Mouse   597 PEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFN 661

  Fly   391 ---PLEARSLPRSSRLRILYAGWLLLVLVLRVVY---------QGKLFDS--------FRLPYHK 435
               |:|.   ||.:..:|:...|....::....|         |.:..|:        |:.|..:
Mouse   662 NSVPVEN---PRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQ 723

  Fly   436 PLPTEISEL--------IRSNYTLINQEYLDY-YPRELTVLT--RNGSKDRFDY------IQGLG 483
            ..|.:...:        |||||..::...:.| .||....||  :.|..|.|.|      .....
Mouse   724 YPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARK 788

  Fly   484 KEG-KFTTT---SLIATMEYYNMMH----WSTSRLTHIKEHIFLYQMVIYLRRHSLLKFAFDRKI 540
            .|| |..|.   .:.||..|...:|    |        |..|.|          :||:|..|.:|
Mouse   789 DEGCKLVTIGSGKVFATTGYGIALHKGSRW--------KRPIDL----------ALLQFLGDDEI 835

  Fly   541 KQLLSAGIIGYFVREFDACQYRKPFEEDYEV--TPIPLDSFCGLYYISLIWLSAAVVAFILELLS 603
            :.|....:.|       .|.     .:..||  :.:.:|:..|::|:.|:.:..:::.|..|.|
Mouse   836 EMLERLWLSG-------ICH-----NDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL- 887

  Fly   604 QRIVWLRR 611
              :.|..|
Mouse   888 --VYWRLR 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:415822	28/165 (17%)
Grin2d	XP_036008580.1	PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	97/482 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810