DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7a and Grik3

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001074566.1	Gene:	Grik3 / 14807	MGIID:	95816	Length:	919	Species:	Mus musculus

Alignment Length:	514	Identity:	98/514 - (19%)
Similarity:	179/514 - (34%)	Gaps:	123/514 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 LNMDCDLSVNLELIDIYKNGLFRHG-------------HEARSFNRVLSLSGCPLQVSWYPLPPF 228
            |..|.|    |::|.:.::||.:.|             .:.|..|...||:...|.|:.....||
Mouse   386 LRTDFD----LDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPF 446

  Fly   229 VSF-------IGNSSDPEERAQIWRLTGIDGELIKLLASI--FDFRILLEEPCNKCLSPDIKDDC 284
            |.|       .||.          |..|...:|:|.||.|  |.:.|.|.|. .|..:.|.|...
Mouse   447 VMFRKSDRTLYGND----------RFEGYCIDLLKELAHILGFSYEIRLVED-GKYGAQDDKGQW 500

  Fly   285 SGCFDQVIISNSSILIGAMSGSHQHRSHFSFTSSYHQSSLVFIMHMSSQFG-AVAQLAVPFTVIV 348
            :|...::|...:.:.:..::.:|.......|:..:....:..:....:... :|.....|.:..:
Mouse   501 NGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDI 565

  Fly   349 WLALVVSSLLLVLVLWMRNRL---------VCG-RSDLASHALQVLTTL---MGNPLEARS--LP 398
            |:.::::.|.:..||::..|.         .|. .|::..:...:|.:.   ||:.::..|  :|
Mouse   566 WMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMP 630

  Fly   399 RSSRLRILYAGWLLLVLVLRVVYQGKLFDSFRLPYHKPLPTEISELIRSNYTLINQEYLDYYPRE 463
            ::...||:...|....|::...|...| .:|........|.:.::      .|..|..::|
Mouse   631 KALSTRIIGGIWWFFTLIIISSYTANL-AAFLTVERMESPIDSAD------DLAKQTKIEY---- 684

  Fly   464 LTVLTRNGSKDRFDYIQGLGKEG---KFTTTSLIATME-YYNMMHWSTSRLTHIKEHIF---LYQ 521
                             |..|:|   .|...|.|:|.| .:..|....|.|....|...   |..
Mouse   685 -----------------GAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTA 732

  Fly   522 MVIYLRRHSLLKFAFDRKIKQLLSAGII---GYFV-------------------REFDACQYRK- 563
            ....|...:.:::...|........|:|   ||.:                   :|.|.....|
Mouse   733 DYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKE 797

  Fly   564 --------PFEEDYEVTPIPLDSFCGLYYISLIWLSAAVVAFILELLSQRIVWLRRIFE 614
                    |.||:.|.:.:.:....|::.:    |:|.:|..:|..:.:.|..||:..|
Mouse   798 KWWRGSGCPEEENKEASALGIQKIGGIFIV----LAAGLVLSVLVAVGEFIYKLRKTAE 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
Grik3	NP_001074566.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	8/34 (24%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	73/406 (18%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810