DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7a and Grik4

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	715	Identity:	140/715 - (19%)
Similarity:	255/715 - (35%)	Gaps:	195/715 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LEILAEQVSPSQSTLAV--MDLTQDAEH--RDERQEQLMTIILRSVGSEMALRTFQKPPAEVPAS 95
            ||.|..|...|:.||:|  :|.|:|...  ::.|.::..|||:.               |....|
Mouse   175 LEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIH---------------ANASMS 224

  Fly    96 FVVFLVNSAQAFNTLGFHFTDIHSTREFNFLILLTHRMSSRA-ERLQVL------------RDIS 147
            ..:.|  .|.....:..::|.|.:..||:.     .||.|.. :|:.:|            ::.|
Mouse   225 HTILL--KAAELGMVSAYYTYIFTNLEFSL-----QRMDSLVDDRVNILGFSIFNQSHAFFQEFS 282

  Fly   148 RT--------C--VRF---HTSNVILLTEKRDGV-VLVYAYRLLNMDCDLSVN------------ 186
            ::        |  |.|   ..|:.:|.    |.| .:|.|.:.||...::.|.
Mouse   283 QSLNQSWQENCDHVPFTGPALSSALLF----DAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQH 343

  Fly   187 --------------------------------LELIDIYKNGLFR----HGHEARSFNRVL---- 211
                                            |:::...:||..:    |..|..|.:..|
Mouse   344 GTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFQQIGQWHVAEGLSMDSRLYASN 408

  Fly   212 ---SLSGCPLQVSWYPLPPFVSFIGNSSDPEERAQIWRLTGIDGELIKLLASI--FDFRILLEEP 271
               ||....|.|:.....|::...||..:.|...   |..|...:::|.||.|  |:::|.|
Mouse   409 ISDSLFNTTLVVTTILENPYLMLKGNHQEMEGND---RYEGFCVDMLKELAEILRFNYKIRL--- 467

  Fly   272 CNKCLS------PDIKDDCSGCFDQVIISNSSILIGAMSGSHQHRSHFSFTSSYHQ--SSLVFIM 328
                :.      |:.....:|...::|...:.:.:..::.:.:......|:..:..  .|:::.:
Mouse   468 ----VGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRV 528

  Fly   329 HMSSQFGAVAQLAVPFTVIVWLALVVSSLLLVLVLWMRNRLV---------C--GRSDLASHALQ 382
            ||..:.|..:.|. ||:..|||.::::.|.:..||::..||.         |  ||.:|..:...
Mouse   529 HMGRRPGYFSFLD-PFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYS 592

  Fly   383 VLTTL---MGNPLEARS--LPRSSRLRILYAGWLLLVLVLRVVYQGKLFDSFRLPYHKPLPTE-- 440
            :..:|   :|..::..|  .||:...|.:...|....|::...|...| .:|.......:|.|
Mouse   593 LGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANL-AAFLTVQRMEVPIESV 656

  Fly   441 --ISELIRSNYTLI----------NQEYLDY-------YPRELTVLTRNGSKDRFDYIQGLGKEG 486
              :::.....|..|          |..|..|       |.::.:|..::..       :|:.:..
Mouse   657 DDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTE-------EGIARVL 714

  Fly   487 KFTTTSLI-ATM-EYYNMMHWSTSRLTHIKEHIFLYQMVIYLRRHSLLKFAFDRKIKQLLSAGII 549
            ......|: :|| |||...:   ..||.|...:......|.:...|:.:..||..|.||.....:
Mouse   715 NSNYAFLLESTMNEYYRQRN---CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRL 776

  Fly   550 GYFVR---EFDACQYRKPFEEDYEVTPIPLDSFCGLYYISLIWLSAAVVAFILELLSQRIVWLRR 611
            ....|   |...|    |.|||:....:.:::..|::.:.:..|..|:...:||.|     |..|
Mouse   777 EILKRKWWEGGKC----PKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL-----WTLR 832

Fly 612 611
Mouse 833 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	47/252 (19%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	76/391 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810