Protein Alignment Rab39 and RAB6A

DIOPT Version :10

• Sequence 1: NP_572405.2
• Gene: Rab39 / 31684
• FlyBaseID: FBgn0029959
• Length: 218
• Species: Drosophila melanogaster
• Sequence 2: NP_002860.2
• Gene: RAB6A / 5870
• HGNCID: 9786
• Length: 208
• Species: Homo sapiens
• Alignment Length: 201
• Identity: 74/201 - (36%)
• Similarity: 116/201 - (57%)
• Gaps: 22/201 - (10%)

  Fly     9 QFRLILIGDSTVGKSSLLKFFTDGKFAELSDPTVGVDFFARLIEMKDGTQIKLQLWDTAGQERFR 73
            :|:|:.:|:.:|||:||:..|....|......|:|:||.::.:.::|.| |:|||||||||||||
Human    13 KFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRT-IRLQLWDTAGQERFR 76

  Fly    74 SITKSYYRNSVGVLLVYDISNHASFEHIPLWM--MEAQRHIEPHRPVFALVGCKLDLINAGGHRE 136
            |:..||.|:|...::||||:|..||:....|:  :..:|..:   .:..|||.|.||.:   .|:
Human    77 SLIPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSD---VIIMLVGNKTDLAD---KRQ 135

  Fly   137 VTTEEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVYARIRSGEYKAEDGWDGIKSGFSRPN 201
            |:.||.::.||:..:.|:||||::|.||::.||.|     |....|....:|.        ||.:
Human   136 VSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRV-----AAALPGMESTQDR--------SRED 187

  Fly   202 SLDFNL 207
            .:|..|
Human   188 MIDIKL 193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab39	NP_572405.2	Rab39	8..218	CDD:133311	74/201 (37%)
RAB6A	NP_002860.2	Rab6	14..174	CDD:206654	68/171 (40%)
		Switch 1. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	32..50		4/17 (24%)
		Switch 2. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	69..88		13/18 (72%)