DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab39 and RAB39B

DIOPT Version :9

Sequence 1:	NP_001245568.1	Gene:	Rab39 / 31684	FlyBaseID:	FBgn0029959	Length:	218	Species:	Drosophila melanogaster
Sequence 2:	NP_741995.1	Gene:	RAB39B / 116442	HGNCID:	16499	Length:	213	Species:	Homo sapiens

Alignment Length:	217	Identity:	114/217 - (52%)
Similarity:	164/217 - (75%)	Gaps:	4/217 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VEPIFEYQFRLILIGDSTVGKSSLLKFFTDGKFAELSDPTVGVDFFARLIEMKDGTQIKLQLWDT 66
            :|.|:.||||||:|||||||||.|::.||:|:||::||||||||||:||:|::.|.:||||:|||
Human     1 MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDFFSRLVEIEPGKRIKLQIWDT 65

  Fly    67 AGQERFRSITKSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHRPVFALVGCKLDLINA 131
            ||||||||||::|||||||.||::||:|..||:::..|:.|.:.|::|::.||.|||.|.||
Human    66 AGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDL--- 127

  Fly   132 GGHREVTTEEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVYARIRSGEYKAEDGWDGIKSG 196
            ...|:||..||:|.|..:|:.::|||||...|||:||..:|:::|..::.||...::||:|:|||
Human   128 DTQRQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSG 192

  Fly   197 FSRPNSLDFNLVVAEPEKSSCC 218
            |. ||.:..:..|.:.|:...|
Human   193 FV-PNVVHSSEEVVKSERRCLC 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab39	NP_001245568.1	Rab39	8..218	CDD:133311	111/209 (53%)
RAB39B	NP_741995.1	Rab39	7..213	CDD:133311	111/209 (53%)
RAB39B	NP_741995.1	Effector region. /evidence=ECO:0000250	37..45		7/7 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I3038
eggNOG	1	0.900	-	-		E2759_KOG0091
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62377
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3384
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1416096at2759
OrthoFinder	1	1.000	-	-		FOG0003983
OrthoInspector	1	1.000	-	-		otm40665
orthoMCL	1	0.900	-	-		OOG6_105997
Panther	1	1.100	-	-	O	PTHR47979
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3742
SonicParanoid	1	1.000	-	-		X2743
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.860