DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdp and PPM1G

DIOPT Version :9

Sequence 1:	NP_001245567.1	Gene:	Pdp / 31683	FlyBaseID:	FBgn0029958	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_817092.1	Gene:	PPM1G / 5496	HGNCID:	9278	Length:	546	Species:	Homo sapiens

Alignment Length:	320	Identity:	71/320 - (22%)
Similarity:	121/320 - (37%)	Gaps:	83/320 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 GIFDGHAGAACGQVVSKRLLRYVSAATLPRQVLREQMKQGADSQSFLKCHNDNVDFVSMIKPMYE 154
            ||..|.||.:|.....|          |||          .....|.:...|..|         |
Human   231 GIPTGEAGPSCSSASDK----------LPR----------VAKSKFFEDSEDESD---------E 266

  Fly   155 ASFLKYVNQLLETPQRDVSSELVNAFLQLDEEISQEALTSNDVRTMNVAL------------SGA 207
            |...:..::.....:...|||  .|..:.||:.::||...::.....:.:            ||.
Human   267 AEEEEEDSEECSEEEDGYSSE--EAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGT 329

  Fly   208 VACLVHIEGLQMHVASTGDCGAVLGVLDPQTQQWHSKKLNIEHNADNMSEVRRILAEHPKEEHET 272
            .|.:..|.|.|:.||:.||...|:      ::...:..::.:|..::..|:.||     |.....
Human   330 TAVVALIRGKQLIVANAGDSRCVV------SEAGKALDMSYDHKPEDEVELARI-----KNAGGK 383

  Fly   273 VIRNGRLLSQLAPLRAFGDFRYKWSQEIMQQKVLPMFGVQAMAPNYYTPP---YLTARPDVQQHE 334
            |..:||:...|...||.||..||.::.:                    ||   .::|.||::...
Human   384 VTMDGRVNGGLNLSRAIGDHFYKRNKNL--------------------PPEEQMISALPDIKVLT 428

  Fly   335 LGPNDKFLVIASDGLWDFLPPSEVVSLVGEHINSKKILEPMRLPEGDTTLQEISQQLAER 394
            |..:.:|:|||.||:|:.:...|||..:...|:.:.....:||      |..|.::|.::
Human   429 LTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRL------LSSIVEELLDQ 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdp	NP_001245567.1	PP2Cc	58..394	CDD:238083	71/318 (22%)
PPM1G	NP_817092.1	PP2Cc	25..>110	CDD:214625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..139
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..328		23/127 (18%)
		PP2Cc	<324..505	CDD:238083	48/196 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..546
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900