DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdp and PPM1A

DIOPT Version :9

Sequence 1:	NP_001245567.1	Gene:	Pdp / 31683	FlyBaseID:	FBgn0029958	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	XP_016876870.1	Gene:	PPM1A / 5494	HGNCID:	9275	Length:	459	Species:	Homo sapiens

Alignment Length:	331	Identity:	71/331 - (21%)
Similarity:	115/331 - (34%)	Gaps:	100/331 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 EDSRTEA----SFLHRNGFICGIFDGHAGAACGQVVSKRLLRYVSAATLPRQVLREQMKQGADSQ 133
            ||:.|..    |.|....|. .::|||||:...:...:.||.:::
Human   114 EDAHTAVIGLPSGLESWSFF-AVYDGHAGSQVAKYCCEHLLDHIT-------------------- 157

  Fly   134 SFLKCHNDNVDFV-SMIKPMYEASFLKYVNQLLETPQRDVSSELVNAFLQLDEEISQEALTSNDV 197
                   :|.||. |...|..|                :|.:.:...||::||.          :
Human   158 -------NNQDFKGSAGAPSVE----------------NVKNGIRTGFLEIDEH----------M 189

  Fly   198 RTMN-----VALSGAVACLVHIEGLQMHVASTGDCGAVLGVLDPQTQQWHSKKLNI---EHNADN 254
            |.|:     ...||:.|..|.|.....:..:.||...:|         ..::|::.   :|...|
Human   190 RVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLL---------CRNRKVHFFTQDHKPSN 245

  Fly   255 MSEVRRILAEHPKEEHETVIRNGRLLSQLAPLRAFGDFRYKWSQEIMQQKVLPMFGVQAMAPNYY 319
            ..|..||      :.....:...|:...||..||.|||.||.              |....|
Human   246 PLEKERI------QNAGGSVMIQRVNGSLAVSRALGDFDYKC--------------VHGKGP--- 287

  Fly   320 TPPYLTARPDVQQHELG-PNDKFLVIASDGLWDFLPPSEVVSLVGEHINSKKILEPMRLPEGDTT 383
            |...::..|:|...|.. .:|:|:::|.||:||.:...|:...|...:.....||.:.....||.
Human   288 TEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTC 352

  Fly   384 LQEISQ 389
            |.:.|:
Human   353 LYKGSR 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdp	NP_001245567.1	PP2Cc	58..394	CDD:238083	71/331 (21%)
PPM1A	XP_016876870.1	PP2Cc	100..368	CDD:238083	71/331 (21%)
PPM1A	XP_016876870.1	PP2C_C	362..437	CDD:285117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830