DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdp and Pdp2

DIOPT Version :9

Sequence 1:	NP_001245567.1	Gene:	Pdp / 31683	FlyBaseID:	FBgn0029958	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_659559.2	Gene:	Pdp2 / 246311	RGDID:	628812	Length:	530	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	187/488 - (38%)
Similarity:	273/488 - (55%)	Gaps:	55/488 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FVLNDAASYVRSNVREFSLNALRLLPQLPQLSPYDVNLVLRENE-----FVYNFPVDGVIRSYET 63
            |.|..|..:..:...:|.|          ||||..|:.:||..|     ..:|..|...:..:|:
  Rat    58 FALRKAYRHTSTEEEDFHL----------QLSPEQVSDLLRAGESSHKVLDFNSGVPNSVLRFES 112

  Fly    64 NQLGSNWPCEDSRTEASFLHRNGFICGIFDGHAGAACGQVVSKRLLRYVSAATLPRQVLREQMKQ 128
            |||.:|.|.||.:..||.:...|.:.||||||.|.||.|.||:||..|::.:.:..:.| |||::
  Rat   113 NQLAANSPVEDRQGVASCVQTRGTMFGIFDGHGGHACAQAVSERLFYYMAVSLMSHKTL-EQMEE 176

  Fly   129 GADSQ-------SFLKCHNDNV--DFVSMIKPMYEASFLK-YVNQLLET-PQRDVSSE--LVNAF 180
            ..::.       .:||...|::  |..|:     ....|: |..:||:. .:..:|:|  |:.:|
  Rat   177 AMENMKPLLPILQWLKHPGDSIYKDITSV-----HLDHLRVYWQELLDLHMETGLSTEEALMYSF 236

  Fly   181 LQLDEEIS-------QEALTSNDVRTMNVALSGAVACLVHIEGLQMHVASTGDCGAVLGVLDPQT 238
            .:||.:||       ::.:|.|  .::.||.|||.||:.|::|:.:|:|:.|||.|:||| ....
  Rat   237 QRLDSDISLEIQAPLEDEVTKN--LSLQVAFSGATACMAHVDGVHLHIANAGDCRAILGV-QGDN 298

  Fly   239 QQWHSKKLNIEHNADNMSEVRRILAEHPKEEHETVIRNGRLLSQLAPLRAFGDFRYKWSQEIMQQ 303
            ..|....|..:|||.|.:|:.|:..|||:.|..|:|.:.|||..|.|.|||||.:.|||:|:.:.
  Rat   299 GAWSCLPLTCDHNAWNEAELSRLKREHPESEDRTLIIDDRLLGVLLPCRAFGDVQLKWSKELQRN 363

  Fly   304 KVLPMFGVQAM------APNYYTPPYLTARPDVQQHELGPNDKFLVIASDGLWDFLPPSEVVSLV 362
            .:...|..:|:      .|:|:|||||||:|:|..|.|.|.|||||:|||||||.|...:||.||
  Rat   364 VLERGFDTEALNIYQFTPPHYHTPPYLTAKPEVTYHRLRPQDKFLVLASDGLWDMLDNEDVVRLV 428

  Fly   363 GEHINSKKILEPMRLPEGDTTLQEISQQLAERKA-GLTRKPVDQNAATHLIRHALGGTDYG-IEH 425
            ..|::.....:| .|.:....|..:...|.:||| ||  ...||||||||||||:|..:|| :|.
  Rat   429 VGHLSKVGHQKP-ALDQRPANLGHMQSLLLQRKASGL--HAADQNAATHLIRHAIGSNEYGEMEP 490

  Fly   426 SKISYYLTLPRDAVRLYRDDITITVIYFNSEHI 458
            .:::..||||.|..|:||||||:.|::||||.|
  Rat   491 ERLAAMLTLPEDVARMYRDDITVMVVFFNSESI 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdp	NP_001245567.1	PP2Cc	58..394	CDD:238083	133/361 (37%)
Pdp2	NP_659559.2	PP2Cc	96..516	CDD:214625	168/431 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338463
Domainoid	1	1.000	177	1.000	Domainoid score	I3493
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2466
OMA	1	1.010	-	-		QHG52867
OrthoDB	1	1.010	-	-		D186269at33208
OrthoFinder	1	1.000	-	-		FOG0002436
OrthoInspector	1	1.000	-	-		otm46380
orthoMCL	1	0.900	-	-		OOG6_101170
Panther	1	1.100	-	-	LDO	PTHR13832
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X558
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770