DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdp and TAB1

DIOPT Version :9

Sequence 1:	NP_001245567.1	Gene:	Pdp / 31683	FlyBaseID:	FBgn0029958	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_006107.1	Gene:	TAB1 / 10454	HGNCID:	18157	Length:	504	Species:	Homo sapiens

Alignment Length:	447	Identity:	97/447 - (21%)
Similarity:	161/447 - (36%)	Gaps:	168/447 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RSYETNQLGS-NWPCEDS----RTEASFLHRNGFICGIFDGHAGAACGQVVSKRLLRYVSAATLP 118
            |||..:..|: :.|.|||    |:|     .|.|:.|:|:|:.|......|::||    ||..|.
Human    35 RSYSADGKGTESHPPEDSWLKFRSE-----NNCFLYGVFNGYDGNRVTNFVAQRL----SAELLL 90

  Fly   119 RQV--------LREQMKQGAD--SQSFLKCHNDNVDFVSMIKPMYEASFLKYVNQLLE-TPQRDV 172
            .|:        :|..:.|..|  .:|||:..:|         .:.|.:.|:  :||.| .||..:
Human    91 GQLNAEHAEADVRRVLLQAFDVVERSFLESIDD---------ALAEKASLQ--SQLPEGVPQHQL 144

  Fly   173 S---SELVNAFLQLDEEISQEA------LTSNDVRTMNVALSGAVACLVHIEGLQMHVASTGDCG 228
            .   .:::.....|:.|||..|      |.:|.:...||..:.|:.|...::|||:
Human   145 PPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQV--------- 200

  Fly   229 AVLGVLDPQTQQWHSKKLNIEHNADNMSEVRRILAEHPKEEHETVIRNGRLLSQLA--------- 284
                     ||      ||::|..:|..|:.|                   ||||.
Human   201 ---------TQ------LNVDHTTENEDELFR-------------------LSQLGLDAGKIKQV 231

  Fly   285 -------PLRAFGDFRYKWSQEIMQQKVLPMFGVQAMAPNYYTPPYLTARPDVQQHELGPND--- 339
                   ..|..||::.|:...          .:..::.....|  :.|.|::  |...|.|
Human   232 GIICGQESTRRIGDYKVKYGYT----------DIDLLSAAKSKP--IIAEPEI--HGAQPLDGVT 282

  Fly   340 KFLVIASDGLWDFLPPS--------EVVSLVGEHINSKKILEPMRLPEGDTTLQEISQQLAERKA 396
            .|||:.|:||:..|..:        |:.:::......:            |:|..::|.:
Human   283 GFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQ------------TSLDAVAQAV----- 330

  Fly   397 GLTRKPVDQNAATHLIRHALGGTDYGIEHSKISYYLTLPRDAVRLYRDDITITVIYF 453
                  ||:....|....|.||     |.::.     .||      .:|:|:.|..|
Human   331 ------VDRVKRIHSDTFASGG-----ERARF-----CPR------HEDMTLLVRNF 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdp	NP_001245567.1	PP2Cc	58..394	CDD:238083	84/386 (22%)
TAB1	NP_006107.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		PP2C	69..334	CDD:395385	72/359 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..478
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144770
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830