DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NELF-B and Nelfb

DIOPT Version :9

Sequence 1:	NP_572402.1	Gene:	NELF-B / 31681	FlyBaseID:	FBgn0027553	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_067368.3	Gene:	Nelfb / 58202	MGIID:	1931035	Length:	628	Species:	Mus musculus

Alignment Length:	586	Identity:	309/586 - (52%)
Similarity:	413/586 - (70%)	Gaps:	24/586 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GLEDVNIPGQAYLREALTSCTDPLKAIESFQLENGVLLPSLRPMLPLLDLHGVRRLDFHTSLMEE 78
            ||:|:.:.....|:|.||:||:||||||.||.|||||||||:..||.|||||..||:||.|:.:|
Mouse    52 GLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLEFHQSVFDE 116

  Fly    79 LRDKLIAHINEMGQK-EPRERDKKLKELLVKSFPVVRVKSLRPVVMAILRNTQHIDDKYLKILVR 142
            |||||:..::.:..: :..||.|||::||.|||.:|::.||:||||.::::...:.:|.||:::.
Mouse   117 LRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKVPEKKLKLVMA 181

  Fly   143 DRELYADTDTEVKRQIWRDNQSLFGDEVSPLLSQYIREKEHILFDHTNLNNL--FFHPTPKVRRQ 205
            |:|||.....|||||||:|||:||||||||||.|||.|||..||. |.|:.|  ||.|:||.|||
Mouse   182 DKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFS-TELSVLHNFFSPSPKTRRQ 245

  Fly   206 GEVVQKLANMIGTSVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMALHDLEVQEIISIDPCHKF 270
            |||||||..|:|.:||||||||||||||||||||||||||||||||:||||:|.:|.::||||||
Mouse   246 GEVVQKLTQMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDVSDICTVDPCHKF 310

  Fly   271 TWCLDACIREKNVDIKRSRELQGFLDNIKRGQEQVLGDLSMTLCDPYAINFLATSAIKILHHLIN 335
            ||||||||||:.||.||:||||||||.:|:|||||||||||.||||:|||.|:.|.|:.|..|::
Mouse   311 TWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLSLSTIRHLQELVS 375

  Fly   336 NEGMPRDNQILILLLRMLALGLSAWVMIDSQDFKEPKLDCQVVTKFLPALMSLMVDDQCRSLHAK 400
            .|.:|||:..|:||||:||||..||.:||||.|||||::.:::|||||.||||:|||...::..|
Mouse   376 QETLPRDSPDLLLLLRLLALGQGAWDLIDSQVFKEPKMEAELITKFLPMLMSLVVDDFTFNVDQK 440

  Fly   401 LPPDERESALTTIEHSGPAPDAVEAYIQESSVASILAMYYTLHTARLKDRVGVLRVLAILSACKD 465
            ||.:|:.|    :.:....|::...::||..:|..:.:||.||..:.:::..:||:|..|.....
Mouse   441 LPAEEKAS----VTYPNTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVETFG 501

  Fly   466 DRAYEDPFLHSLIALLIPMSEEFATEDFCTTLFDEFIFAGLTRENVTSRHMLKLLWYVHNKLPAG 530
            |.|:.|.|||.|...|:.:::|||.||||::|||.|......|:....||:|:||.::|.::...
Mouse   502 DLAFSDIFLHLLTGSLVLLADEFALEDFCSSLFDGFFLTASPRKENVHRHVLRLLLHLHARVAPS 566

  Fly   531 RLATLMKAMQPTTAHNEHIHKLYEILQERI---------GTGAAETPVIEAPPMEFDSPLKSVPT 586
            :|..|.||::||....|.:.:||..|.|::         .|.|||||.:       |.||.|||.
Mouse   567 KLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDHRKPSPTQAAETPAL-------DLPLPSVPA 624

  Fly   587 P 587
            |
Mouse   625 P 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NELF-B	NP_572402.1	COBRA1	116..588	CDD:283791	254/483 (53%)
Nelfb	NP_067368.3	COBRA1	155..626	CDD:283791	254/483 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835063
Domainoid	1	1.000	488	1.000	Domainoid score	I382
eggNOG	1	0.900	-	-		E1_2C1MK
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121600
Inparanoid	1	1.050	595	1.000	Inparanoid score	I962
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48738
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008294
OrthoInspector	1	1.000	-	-		oto93529
orthoMCL	1	0.900	-	-		OOG6_105765
Panther	1	1.100	-	-	LDO	PTHR13503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6276
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760