DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NELF-B and Nelfb

DIOPT Version :9

Sequence 1:	NP_572402.1	Gene:	NELF-B / 31681	FlyBaseID:	FBgn0027553	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001101287.3	Gene:	Nelfb / 311796	RGDID:	1307832	Length:	631	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	306/586 - (52%)
Similarity:	410/586 - (69%)	Gaps:	24/586 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GLEDVNIPGQAYLREALTSCTDPLKAIESFQLENGVLLPSLRPMLPLLDLHGVRRLDFHTSLMEE 78
            ||:|:.:.....|:|.||:||:||||||.||.|||||||||:..||.|||||..||:||.|:.:|
  Rat    55 GLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLEFHQSVFDE 119

  Fly    79 LRDKLIAHINEMGQK-EPRERDKKLKELLVKSFPVVRVKSLRPVVMAILRNTQHIDDKYLKILVR 142
            |||||:..::.:..: :..||.|||::||.|||.:|::.||:||||.::::...:.:|.||:::.
  Rat   120 LRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKVPEKKLKLVMA 184

  Fly   143 DRELYADTDTEVKRQIWRDNQSLFGDEVSPLLSQYIREKEHILFDHTNLNNL--FFHPTPKVRRQ 205
            |:|||.....|||||||:|||:||||||||||.|||.|||..||. |.|:.|  ||.|:||.|||
  Rat   185 DKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFS-TELSVLHNFFSPSPKTRRQ 248

  Fly   206 GEVVQKLANMIGTSVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMALHDLEVQEIISIDPCHKF 270
            |||||||..|:|.:||||||||||||||||||||||||||||||||:||||:|.:|.::||||||
  Rat   249 GEVVQKLTQMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDVSDICTVDPCHKF 313

  Fly   271 TWCLDACIREKNVDIKRSRELQGFLDNIKRGQEQVLGDLSMTLCDPYAINFLATSAIKILHHLIN 335
            ||||||||||:.||.||:||||||||.:|:|||||||||||.||||:|||.|:.|.|:.|..|::
  Rat   314 TWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLSLSTIRHLQELVS 378

  Fly   336 NEGMPRDNQILILLLRMLALGLSAWVMIDSQDFKEPKLDCQVVTKFLPALMSLMVDDQCRSLHAK 400
            .|.:|||:..|:||||:||||..||.:||||.|||||::.:::|||||.|||.:|||...::..|
  Rat   379 QETLPRDSPDLLLLLRLLALGQGAWDLIDSQVFKEPKMEAELITKFLPMLMSFVVDDYTFNVDQK 443

  Fly   401 LPPDERESALTTIEHSGPAPDAVEAYIQESSVASILAMYYTLHTARLKDRVGVLRVLAILSACKD 465
            ||.:|:    ..:.:....|::...::||..:|..:.:||.||..:.:::..:||:|..|.....
  Rat   444 LPAEEK----APVTYPNTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVETFG 504

  Fly   466 DRAYEDPFLHSLIALLIPMSEEFATEDFCTTLFDEFIFAGLTRENVTSRHMLKLLWYVHNKLPAG 530
            |.|:.|.|||.|...|..:::|||.||||::|||.|......|::...||:|:||.::|.::...
  Rat   505 DLAFSDIFLHLLTGSLALLADEFALEDFCSSLFDGFFLTASPRKDNVHRHVLRLLLHLHARVAPS 569

  Fly   531 RLATLMKAMQPTTAHNEHIHKLYEILQERI---------GTGAAETPVIEAPPMEFDSPLKSVPT 586
            :|..|.||::||....|.:.:||..|.|::         ...|||||.:|.       ||.|||.
  Rat   570 KLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDHRKPSPPQAAETPALEL-------PLPSVPA 627

  Fly   587 P 587
            |
  Rat   628 P 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NELF-B	NP_572402.1	COBRA1	116..588	CDD:283791	251/483 (52%)
Nelfb	NP_001101287.3	COBRA1	158..629	CDD:283791	251/483 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338661
Domainoid	1	1.000	483	1.000	Domainoid score	I387
eggNOG	1	0.900	-	-		E1_2C1MK
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121600
Inparanoid	1	1.050	589	1.000	Inparanoid score	I958
OMA	1	1.010	-	-		QHG48738
OrthoDB	1	1.010	-	-		D1095614at2759
OrthoFinder	1	1.000	-	-		FOG0008294
OrthoInspector	1	1.000	-	-		oto97071
orthoMCL	1	0.900	-	-		OOG6_105765
Panther	1	1.100	-	-	LDO	PTHR13503
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6276
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770