DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NELF-B and NELFB

DIOPT Version :9

Sequence 1:	NP_572402.1	Gene:	NELF-B / 31681	FlyBaseID:	FBgn0027553	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_056271.3	Gene:	NELFB / 25920	HGNCID:	24324	Length:	628	Species:	Homo sapiens

Alignment Length:	588	Identity:	307/588 - (52%)
Similarity:	408/588 - (69%)	Gaps:	24/588 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GLEDVNIPGQAYLREALTSCTDPLKAIESFQLENGVLLPSLRPMLPLLDLHGVRRLDFHTSLMEE 78
            ||:|:.:.....|:|.||:||:||||||.||.|||||||||:..||.|||||..||:||.|:.:|
Human    52 GLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLEFHQSVFDE 116

  Fly    79 LRDKLIAHINEMGQK-EPRERDKKLKELLVKSFPVVRVKSLRPVVMAILRNTQHIDDKYLKILVR 142
            |||||:..::.:..: :..||.|||::||.|||.:|::.||:||||.::::...:.:|.||:::.
Human   117 LRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKVPEKKLKLVMA 181

  Fly   143 DRELYADTDTEVKRQIWRDNQSLFGDEVSPLLSQYIREKEHILFDHTNLNNL--FFHPTPKVRRQ 205
            |:|||.....|||||||:|||:||||||||||.|||.|||..||. |.|:.|  ||.|:||.|||
Human   182 DKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFS-TELSVLHNFFSPSPKTRRQ 245

  Fly   206 GEVVQKLANMIGTSVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMALHDLEVQEIISIDPCHKF 270
            |||||:|..|:|.:||||||||||||||||||||||||||||||||:||||:|.||.::||||||
Human   246 GEVVQRLTRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDVGEICTVDPCHKF 310

  Fly   271 TWCLDACIREKNVDIKRSRELQGFLDNIKRGQEQVLGDLSMTLCDPYAINFLATSAIKILHHLIN 335
            ||||||||||:.||.||:||||||||.:|:|||||||||||.||||:|||.||.|.::.|..|:.
Human   311 TWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLALSTVRHLQELVG 375

  Fly   336 NEGMPRDNQILILLLRMLALGLSAWVMIDSQDFKEPKLDCQVVTKFLPALMSLMVDDQCRSLHAK 400
            .|.:|||:..|:||||:||||..||.|||||.|||||::.:::|:|||.|||.:|||...::..|
Human   376 QETLPRDSPDLLLLLRLLALGQGAWDMIDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQK 440

  Fly   401 LPPDERESALTTIEHSGPAPDAVEAYIQESSVASILAMYYTLHTARLKDRVGVLRVLAILSACKD 465
            ||.:|:    ..:.:....|::...::||..:|..:.:||.||..:.:::..:||:|..|.....
Human   441 LPAEEK----APVSYPNTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVETFG 501

  Fly   466 DRAYEDPFLHSLIALLIPMSEEFATEDFCTTLFDEFIFAGLTRENVTSRHMLKLLWYVHNKLPAG 530
            |.|:.|.|||.|...|..:::|||.||||::|||.|......|:....||.|:||.::|.::...
Human   502 DLAFGDIFLHLLTGNLALLADEFALEDFCSSLFDGFFLTASPRKENVHRHALRLLIHLHPRVAPS 566

  Fly   531 RLATLMKAMQPTTAHNEHIHKLYEILQERI---------GTGAAETPVIEAPPMEFDSPLKSVPT 586
            :|..|.||::||....|.:.:||..|.|::         ...|||||.:|.       ||.|||.
Human   567 KLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDHRKPSPAQAAETPALEL-------PLPSVPA 624

  Fly   587 PGP 589
            |.|
Human   625 PAP 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NELF-B	NP_572402.1	COBRA1	116..588	CDD:283791	250/482 (52%)
NELFB	NP_056271.3	COBRA1	155..626	CDD:283791	250/482 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144957
Domainoid	1	1.000	480	1.000	Domainoid score	I416
eggNOG	1	0.900	-	-		E1_2C1MK
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121600
Inparanoid	1	1.050	589	1.000	Inparanoid score	I996
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48738
OrthoDB	1	1.010	-	-		D1095614at2759
OrthoFinder	1	1.000	-	-		FOG0008294
OrthoInspector	1	1.000	-	-		oto89954
orthoMCL	1	0.900	-	-		OOG6_105765
Panther	1	1.100	-	-	LDO	PTHR13503
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4684
SonicParanoid	1	1.000	-	-		X6276
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800