DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NELF-B and AgaP_AGAP012109

DIOPT Version :9

Sequence 1:	NP_572402.1	Gene:	NELF-B / 31681	FlyBaseID:	FBgn0027553	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_320419.3	Gene:	AgaP_AGAP012109 / 1280567	VectorBaseID:	AGAP012109	Length:	566	Species:	Anopheles gambiae

Alignment Length:	565	Identity:	491/565 - (86%)
Similarity:	527/565 - (93%)	Gaps:	6/565 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ALTSCTDPLKAIESFQLENGVLLPSLRPMLPLLDLHGVRRLDFHTSLMEELRDKLIAHINEMGQK 93
            :|:.|.|||||||:||:|||:|||||||||||||||||||||||||::|||||||||||||:|.|
Mosquito     4 SLSECDDPLKAIETFQVENGILLPSLRPMLPLLDLHGVRRLDFHTSVLEELRDKLIAHINELGAK 68

  Fly    94 EPRERDKKLKELLVKSFPVVRVKSLRPVVMAILRNTQHIDDKYLKILVRDRELYADTDTEVKRQI 158
            |.|:||.||||||||||||||||:||||||.|||||.||:||||:|||||||||.||||||||||
Mosquito    69 EGRQRDAKLKELLVKSFPVVRVKALRPVVMCILRNTPHIEDKYLRILVRDRELYQDTDTEVKRQI 133

  Fly   159 WRDNQSLFGDEVSPLLSQYIREKEHILFDHTNLNNLFFHPTPKVRRQGEVVQKLANMIGTSVKLY 223
            ||||||||||||||||||||||||||||||.|||||||.||||||||||||||||:|||.|||||
Mosquito   134 WRDNQSLFGDEVSPLLSQYIREKEHILFDHLNLNNLFFTPTPKVRRQGEVVQKLAHMIGNSVKLY 198

  Fly   224 DMVLQFLRTLFLRTRNVHYCTLRAELLMALHDLEVQEIISIDPCHKFTWCLDACIREKNVDIKRS 288
            ||||||||||||||||||||||||||||||||||||:|||:||||||||||||||||||||:|||
Mosquito   199 DMVLQFLRTLFLRTRNVHYCTLRAELLMALHDLEVQDIISVDPCHKFTWCLDACIREKNVDMKRS 263

  Fly   289 RELQGFLDNIKRGQEQVLGDLSMTLCDPYAINFLATSAIKILHHLINNEGMPRDNQILILLLRML 353
            ||||||||||||||||||||||||||||||||||||||||||.||||||||||:|.||:||||||
Mosquito   264 RELQGFLDNIKRGQEQVLGDLSMTLCDPYAINFLATSAIKILQHLINNEGMPRENLILVLLLRML 328

  Fly   354 ALGLSAWVMIDSQDFKEPKLDCQVVTKFLPALMSLMVDDQCRSLHAKLPPDERESALTTIEHSGP 418
            |||||||||||||||||||||.||||||||||||||||||.|.||:||||||||||:||||||||
Mosquito   329 ALGLSAWVMIDSQDFKEPKLDSQVVTKFLPALMSLMVDDQVRHLHSKLPPDERESAITTIEHSGP 393

  Fly   419 APDAVEAYIQESSVASILAMYYTLHTARLKDRVGVLRVLAILSACKDDRAYEDPFLHSLIALLIP 483
            |||||||||||::|||||||||||||||.|||||:|||:|||::||||||||||||||||||:||
Mosquito   394 APDAVEAYIQENAVASILAMYYTLHTARQKDRVGILRVMAILASCKDDRAYEDPFLHSLIALIIP 458

  Fly   484 MSEEFATEDFCTTLFDEFIFAGLTRENVTSRHMLKLLWYVHNKLPAGRLATLMKAMQPTTAHNEH 548
            ||:|||.|||||.|||||:||||||:||| |||||||||:|.|||..||.|||||:|||..|:|.
Mosquito   459 MSDEFANEDFCTGLFDEFLFAGLTRDNVT-RHMLKLLWYIHQKLPQARLMTLMKALQPTAQHHES 522

  Fly   549 IHKLYEILQERIGTGAAETPVIEAPPME--FDSPLKSVPTPGPHY 591
            :|||||.||:|:||...|.|   |.|||  |||||||||||||||
Mosquito   523 VHKLYENLQKRVGTLTQEAP---AEPMETDFDSPLKSVPTPGPHY 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NELF-B	NP_572402.1	COBRA1	116..588	CDD:283791	413/473 (87%)
AgaP_AGAP012109	XP_320419.3	COBRA1	91..561	CDD:283791	413/473 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	826	1.000	Domainoid score	I264
eggNOG	1	0.900	-	-		E1_2C1MK
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121600
Inparanoid	1	1.050	1007	1.000	Inparanoid score	I896
OMA	1	1.010	-	-		QHG48738
OrthoDB	1	1.010	-	-		D1095614at2759
OrthoFinder	1	1.000	-	-		FOG0008294
OrthoInspector	1	1.000	-	-		oto108449
Panther	1	1.100	-	-	LDO	PTHR13503
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6276
TreeFam	1	0.960	-	-
	13	12.940