Protein Alignment Hira and ARC40

DIOPT Version :9

• Sequence 1: NP_572401.2
• Gene: Hira / 31680
• FlyBaseID: FBgn0022786
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_009793.1
• Gene: ARC40 / 852536
• SGDID: S000000438
• Length: 384
• Species: Saccharomyces cerevisiae
• Alignment Length: 483
• Identity: 91/483 - (18%)
• Similarity: 155/483 - (32%)
• Gaps: 174/483 - (36%)

  Fly    40 VVIWNLL--PVLSDKAEFDADVPKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSAG 102
            |.::.|:  |:.|.....|..:..:.|:.|       |                   :::|.|..
Yeast    12 VAVYKLVKAPIYSHCFSQDKSILAVTCETD-------C-------------------LVYRVSNN 50

  Fly   103 SSGVFGTGGMQKNHESWKCFYTLRGHDGDV--LDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSV 165
            :..|.              |.||:.||..:  :|::....   :.:||.|....:|:    |.|.
Yeast    51 TPPVL--------------FATLKDHDKTITAVDISIHGR---IVTCSQDRNAYVWE----PLSD 94

  Fly   166 ATLKGHTGLVK------GVSWDPLGRFLASQSDDRSIKIW---NTMNWSLSHTITEPFEECGGTT 221
            .|.|....|::      .|:|.|.|...|..|..|.|.:.   :..||.:|..|.:|.:     :
Yeast    95 GTYKPTLVLLRINRAATSVTWAPNGYKFAVGSSARIIAVCYYEHENNWWVSKHIKKPIK-----S 154

  Fly   222 HILRLSWSPDGQYLVSAHAMNG-------------------GGPTAQ---------------IIE 252
            .|..|||..:| .|::|...:|                   |.|..|               .|.
Yeast   155 TINCLSWHANG-VLLAAGGTDGFMRVFSGFIKGLDSKESVAGSPWGQKFPFGCLIREWYQGSYIH 218

  Fly   253 REGWKCDKD---FVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVWMTALQ 314
            ...|:...:   :|.|...:..|.:.:.:.|....:|.|.:.|               ||:..
Yeast   219 DVEWRSQMERIAYVAHDGTLNVVDYQSPVQSVNAPEGLPYRSL---------------VWIND-- 266

  Fly   315 RPMVVIHELFNASILDLTWGPQECLLMACSVDGSIAC--LKFTEEELGKAISEEEQNAIIRKMYG 377
                  ||:                     |.|..:|  :.|:|      .||           |
Yeast   267 ------HEI---------------------VCGGYSCHPVLFSE------ASE-----------G 287

  Fly   378 KNYVNGLGKSAPVLEHPQRLLLPQGDKPTKFPLSNNNEANQRPISKQTETRTKDGKRRI-TPMFI 441
            ..:...|.||.   .:....|...|:  |.....||:|::...||...:.:..|.|.:: |.:..
Yeast   288 WKFAKNLDKSD---NNKSSALTASGN--TDELSGNNDESSTFGISALRKFKELDLKGKVSTDVQE 347

  Fly   442 PLHEDGPTSLSMNIVSSSGSSTTALTSC 469
            ..||:  ..:.:...:.|....|.::||
Yeast   348 SAHEN--AIVELRPFAESNGQITQVSSC 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	70/381 (18%)
		WD40	14..349	CDD:238121	65/358 (18%)
		WD40 repeat	16..68	CDD:293791	6/29 (21%)
		WD40 repeat	74..127	CDD:293791	7/52 (13%)
		WD40 repeat	132..169	CDD:293791	8/38 (21%)
		WD40 repeat	176..211	CDD:293791	11/43 (26%)
		WD40 repeat	223..263	CDD:293791	13/76 (17%)
		WD40 repeat	275..322	CDD:293791	6/46 (13%)
		WD40 repeat	328..350	CDD:293791	2/21 (10%)
		HIRA_B	423..442	CDD:286531	3/19 (16%)
		Hira	629..820	CDD:284895
ARC40	NP_009793.1	WD40	<5..315	CDD:225201	77/421 (18%)
		WD40 repeat	22..61	CDD:293791	11/78 (14%)
		WD40 repeat	67..104	CDD:293791	9/43 (21%)
		WD40 repeat	110..149	CDD:293791	11/38 (29%)
		WD40 repeat	157..203	CDD:293791	10/46 (22%)
		WD40 repeat	217..254	CDD:293791	6/36 (17%)
		WD40 repeat	258..295	CDD:293791	13/97 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910