DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and HIR1

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_009545.2	Gene:	HIR1 / 852275	SGDID:	S000000104	Length:	840	Species:	Saccharomyces cerevisiae

Alignment Length:	870	Identity:	220/870 - (25%)
Similarity:	352/870 - (40%)	Gaps:	184/870 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLLKPAWVHHDDK----QIFSVDIHKDCTKFATGGQGSDCGRVVIWNL--------LPVLSDKA 53
            |:::|..|:.|.::    :|::||:..|..:.||||..   |::.||::        |..|:.:.
Yeast     1 MKVVKFPWLAHREESRKYEIYTVDVSHDGKRLATGGLD---GKIRIWSIDSILRCMELESLTPEI 62

  Fly    54 EFDADVPKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIWR--KSAGSSGVFGTGGMQKNH 116
            ....|:...||.|.:|...:.||::|.:|:.|||||||::::||.  :...|...||:   :...
Yeast    63 PLPQDLQMPLCSMSRHTGSITCVKFSPDGKYLASGSDDRILLIWALDEEQSSQPAFGS---EHER 124

  Fly   117 ESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWD 181
            |.|.....|..||.|:.|:.|:|:...|.:..:|.:||:|:...| ..:.....|..|||||.:|
Yeast   125 EHWTVRKRLVAHDNDIQDICWAPDSSILVTVGLDRSVIVWNGSTF-EKLKRFDVHQSLVKGVVFD 188

  Fly   182 PLGRFLASQSDDRSIKIW-----NTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAM 241
            |..::.|:.||||::||:     ..:::::.|.|||||:|...||:..|.|||||||::...:|.
Yeast   189 PANKYFATTSDDRTMKIFRYHKTGDISFTIEHIITEPFKESPLTTYFRRPSWSPDGQHIAVPNAT 253

  Fly   242 NGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHNSILSR-----QENDGSPSKPLQ-------- 293
            ||...:..|:.|..|..:...:||.......||:..:..|     |:.|..|...|.
Yeast   254 NGPVSSVAIVNRGTWDTNVSLIGHDAPTEVARFNPRLFERNAGVKQKKDDDPENALVGQNDDKVH 318

  Fly   294 ------YCCLAVGSRDRSLSVWMTALQRPMVVIHELFNASILDLTWGPQECLLMACSVDGSIACL 352
                  ...:|...:|:||:||.|:..||::|..::.|.||.|::|.|...||...|:|.||...
Yeast   319 HFDKNIDSVVATAGQDKSLAVWSTSRPRPILVAFDIANKSITDMSWNPDGSLLFVASLDSSITLF 383

  Fly   353 KFTEEELGKAISEEEQNAIIRKMYGKNYVNGLGKSAPVLEHPQ---RLLLPQGDKPTKF------ 408
            ||...||||.|.       :.|...:.|..|:.|.:  |:.|:   :|||....|..|.
Yeast   384 KFENNELGKPIP-------LEKNMEQLYRYGVDKDS--LDFPESINQLLLEDQTKSFKHTKISTS 439

  Fly   409 -------PLSNNNEANQRPISKQTETRT----------------------KDGKRRITPMFIPLH 444
                   .|:.|:.:||:..:..:.:|:                      |.||:|:.|..|...
Yeast   440 KLGENHPTLATNSASNQKDNNDASVSRSEHINILIPKRKKDAILNKAVTLKSGKKRVAPTLISTS 504

  Fly   445 EDG--------PTSLSMNIVSSSGSSTTALTSCSAAIGTLPAAAPTE----SAATPLMPLEPLVS 497
            ...        ||..|..|.::..|||..:.|.:..: .:|.....:    |...|.:.:..|:.
Yeast   505 SSSPFSNGIKKPTLDSKRIENNVKSSTKTINSKNTLL-NVPEGVEKKISISSFPLPRLGIHSLIM 568

  Fly   498 --------KIDLGRLDSRLKTQPASQRRQSLPFDPGQSNELLRTPRLEEH--------------- 539
                    ||.    :|.|:...|......  ...|.||.:.....|.|.
Yeast   569 GTKERSAWKIS----NSELENDDADNAGGK--GSDGTSNSIDDIAVLSEEENDFHRMTLNAKLTQ 627

  Fly   540 --------------QSSTCSPSNLNVTATGKSEFVKAALDYRLHVSNGHLKTQHGMLAKVTASDS 590
                          ||.....:::.|...|..:.: |.|:.|..|..........:|      |:
Yeast   628 EKIWSEEPTTRCLLQSDVIPDTDVVVLEGGSLDDI-AVLEIRNGVERSIQFDSEALL------DN 685

  Fly   591 KEMLWEFYVGSPLVNLNLCE-----------KYAMLCSLDGSMRLISMETGCPVFPAISLTSSAV 644
            ...:..:..|...:...:.|           |...|.|.:||:.::|. .|....|.|.|....:
Yeast   686 PTRILGYQGGKRTIETFIPEVIICAIGSKDCKCWCLASANGSIYILSY-NGQQRIPKICLGHKVI 749

  Fly   645 HCAFSPDNSLVGVLTECGLLRIWDIAK-KVVSLAAGCLELLNK---HGTAAQ-------FSVTNQ 698
            ....|....|  ||||.||...||:.. |:|......|.:||.   ||...:       |.:...
Yeast   750 KMVTSSKYLL--VLTERGLFFAWDLLDLKLVLRNVPILPILNGQPIHGNKVRINKVIKCFRLDGS 812

  Fly   699 GMPL---IGFPSGNSYSYSTSLQSW 720
            ...|   :|.|. |.|.::..|..|
Yeast   813 SCDLLLEVGDPK-NVYKWTKDLGCW 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	125/395 (32%)
		WD40	14..349	CDD:238121	116/372 (31%)
		WD40 repeat	16..68	CDD:293791	17/59 (29%)
		WD40 repeat	74..127	CDD:293791	19/54 (35%)
		WD40 repeat	132..169	CDD:293791	9/36 (25%)
		WD40 repeat	176..211	CDD:293791	13/39 (33%)
		WD40 repeat	223..263	CDD:293791	14/39 (36%)
		WD40 repeat	275..322	CDD:293791	15/65 (23%)
		WD40 repeat	328..350	CDD:293791	9/21 (43%)
		HIRA_B	423..442	CDD:286531	6/40 (15%)
		Hira	629..820	CDD:284895	29/106 (27%)
HIR1	NP_009545.2	WD40	20..384	CDD:421866	118/370 (32%)
		WD40 repeat	20..66	CDD:293791	13/48 (27%)
		WD40 repeat	83..135	CDD:293791	19/54 (35%)
		WD40 repeat	140..176	CDD:293791	9/36 (25%)
		WD40 repeat	183..228	CDD:293791	18/44 (41%)
		WD40 repeat	235..275	CDD:293791	14/39 (36%)
		WD40 repeat	283..350	CDD:293791	16/66 (24%)
		WD40 repeat	359..383	CDD:293791	10/23 (43%)
		Hira	735..>807	CDD:400109	21/73 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344713
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0973
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003162
OrthoInspector	1	1.000	-	-		oto99039
orthoMCL	1	0.900	-	-		OOG6_103167
Panther	1	1.100	-	-	LDO	PTHR13831
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R561
SonicParanoid	1	1.000	-	-		X3052
TreeFam	1	0.960	-	-
	11	10.730