DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hira and RSA4

DIOPT Version :9

Sequence 1:NP_572401.2 Gene:Hira / 31680 FlyBaseID:FBgn0022786 Length:1047 Species:Drosophila melanogaster
Sequence 2:NP_009997.2 Gene:RSA4 / 850435 SGDID:S000000668 Length:515 Species:Saccharomyces cerevisiae


Alignment Length:425 Identity:97/425 - (22%)
Similarity:141/425 - (33%) Gaps:168/425 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 CTKFA-------TGGQGSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQMDQHLACVNCVRWSQNG 82
            |:.||       ..|.|.:..|  ||            |.|....:..:..|...|.||.||.:|
Yeast   148 CSAFAPHTSSRMVTGAGDNTAR--IW------------DCDTQTPMHTLKGHYNWVLCVSWSPDG 198

  Fly    83 QNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCF-YTLRGHDGDVLDLAWSP------- 139
            :.:|:||.|..|.:|...:|                 :|. ..||||...:..|:|.|       
Yeast   199 EVIATGSMDNTIRLWDPKSG-----------------QCLGDALRGHSKWITSLSWEPIHLVKPG 246

  Fly   140 NDVYLASCSIDNTVIIWDAQAFPHSVA-----TLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIW 199
            :...|||.|.|.|:.|||      :|:     |:.|||..|..|.|...| .|.|.|.||::::|
Yeast   247 SKPRLASSSKDGTIKIWD------TVSRVCQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVW 304

  Fly   200 NT-------------MNW----SLS-----------HT--------------------------- 209
            :.             .:|    |||           ||                           
Yeast   305 DINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGN 369

  Fly   210 ---------------------ITEPFEECGGTTHIL-RLSWSPDGQYLVSAHAMNGGGPTAQIIE 252
                                 .|:|.....|...:: .:::||||:|:|||...|    :.::.:
Yeast   370 SEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDN----SIKLWD 430

  Fly   253 REGWKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVG-SRDRSLSVWMTALQRP 316
            ....|....|.||..:|..|.:.:.                 |.|.|. |:|.:|.||....::.
Yeast   431 GRDGKFISTFRGHVASVYQVAWSSD-----------------CRLLVSCSKDTTLKVWDVRTRKL 478

  Fly   317 MVVIHELFNASILDLTWGPQECLLMACSVDGSIAC 351
            .|           ||.....|...:..||||...|
Yeast   479 SV-----------DLPGHKDEVYTVDWSVDGKRVC 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HiraNP_572401.2 WD40 <12..370 CDD:225201 97/425 (23%)
WD40 14..349 CDD:238121 96/421 (23%)
WD40 repeat 16..68 CDD:293791 10/49 (20%)
WD40 repeat 74..127 CDD:293791 14/53 (26%)
WD40 repeat 132..169 CDD:293791 14/48 (29%)
WD40 repeat 176..211 CDD:293791 15/110 (14%)
WD40 repeat 223..263 CDD:293791 10/40 (25%)
WD40 repeat 275..322 CDD:293791 9/47 (19%)
WD40 repeat 328..350 CDD:293791 7/21 (33%)
HIRA_B 423..442 CDD:286531
Hira 629..820 CDD:284895
RSA4NP_009997.2 NLE 32..>79 CDD:400462
WD40 135..472 CDD:238121 87/382 (23%)
WD40 repeat 189..227 CDD:293791 15/54 (28%)
WD40 repeat 233..276 CDD:293791 14/48 (29%)
WD40 repeat 281..316 CDD:293791 10/35 (29%)
WD40 repeat 324..399 CDD:293791 7/74 (9%)
WD40 repeat 405..441 CDD:293791 10/39 (26%)
WD40 repeat 447..483 CDD:293791 12/63 (19%)
WD40 475..513 CDD:197651 9/39 (23%)
WD40 repeat 489..513 CDD:293791 5/14 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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