DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and DWA3

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_176316.4	Gene:	DWA3 / 842414	AraportID:	AT1G61210	Length:	1181	Species:	Arabidopsis thaliana

Alignment Length:	1072	Identity:	212/1072 - (19%)
Similarity:	360/1072 - (33%)	Gaps:	274/1072 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 HLACVNCVRWSQNGQNL-ASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDV 132
            |.|.|||:...:....| .:|.||..:.:|.....:|                 ..:|.||...|
plant    14 HSANVNCLSIGKKTSRLFITGGDDYKVNLWAIGKPTS-----------------LMSLCGHTSAV 61

  Fly   133 LDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIK 197
            ..:|:...:|.:.:.:....:.:||.:. ...|....||......|.:.|.|.||||.|.|.::|
plant    62 DSVAFDSAEVLVLAGASSGVIKLWDVEE-AKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLK 125

  Fly   198 IWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDKDF 262
            ||:........|..      |.:..|..:.::|||:::||....|    ..::.:....|...:|
plant   126 IWDIRKKGCIQTYK------GHSRGISTIRFTPDGRWVVSGGLDN----VVKVWDLTAGKLLHEF 180

  Fly   263 VGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVW------MTALQRP----- 316
            ..|...:..:.||               ||:: .||.||.||::..|      :....||
plant   181 KFHEGPIRSLDFH---------------PLEF-LLATGSADRTVKFWDLETFELIGSTRPEATGV 229

  Fly   317 -MVVIH----ELF---NASILDLTWGPQEC----------LLMACSVDGSIACLKFTEEELGKAI 363
             .:..|    .||   :.|:...:|.|..|          |...|..:|.:....:.:..:|..:
plant   230 RSIKFHPDGRTLFCGLDDSLKVYSWEPVVCHDGVDMGWSTLGDLCISEGKLLGCSYYQNSVGIWV 294

  Fly   364 SEEEQNAIIRKMYGKNYVNGLGKSAPVLEHPQRLLLPQGDKPTKFPLSNNNEANQRPISKQTETR 428
            |:..|.        :.|  |:| ||...|..:::|....|                    |:..|
plant   295 SDISQI--------EPY--GIG-SADKKECVEKILSALDD--------------------QSFDR 328

  Fly   429 TKDGKRRITPMFIPLHEDGPTSLSMNIVSSSGSSTTALTSCSAAIGTLPAAAPTESAATPLMPLE 493
            .|...||.:      ..|..|....||...|....:|:...|.::.| ||.:..::.....:.:.
plant   329 IKSTPRRSS------SPDYETKEIKNIYIDSTGGNSAVAHKSGSLST-PATSTGQAGDNKSLVVH 386

  Fly   494 PLVSKIDLGRLDSRLKTQPASQRRQSLPFDPGQSNELLRTPRLEEHQSSTCSPSNLNVTATGKSE 558
            .:|.:      ||.:....:...::|:.|...:...|||             |:.:..|.|...|
plant   387 SVVPR------DSDIGKDSSDSGKESITFSKTKPGMLLR-------------PAYVRKTPTKFDE 432

  Fly   559 FVKAALDYRLHVSNGHLKTQHGMLAKVTASDSKEMLWEFYVGSPLVNLNLCEKYAMLCSLDGSMR 623
            ..|.:      |:.|:||..                                      .|||..:
plant   433 TKKQS------VAVGYLKKS--------------------------------------GLDGEKK 453

  Fly   624 LISMETGCPVFPAISLTSSAVHCAFSPDNSLVGVLT---ECGLL--RIWDIAKKVVSLAAGCLEL 683
            | ..||      |.....|..: .:..|:|::..:|   |..||  ...|.||        |:.|
plant   454 L-DTET------AFDSEMSGRN-PYDADDSIIKSITNKFEQALLPESPTDEAK--------CMLL 502

  Fly   684 LNKHGTAAQFSVTNQGMPLIGFPSGNSYSYSTSLQSWLVLATKDAIMYHGI---RGTLPRDMDQM 745
            .......:..:..|:........||...|....|:|     ::|..:..|:   ||:.|.:.|..
plant   503 KPPRVQRSPSTKYNEARWATSTDSGALDSKKNGLES-----SRDMDLPTGLRDDRGSNPCEEDIE 562

  Fly   746 QQKFP-----LLSMQASSQNYFSFTGSMELRHSESWQQCAKIRFIENQIK-LCEALQSLDELQHW 804
            .:...     :||.:.:.....|.......:.|:|.:....::.:..:.: |.|..:..:::.|.
plant   563 NKSISSRSERVLSPEKAGDELKSLESPGGSKESKSVKVVRGVKVVSGRTRSLVERFERGEKITHS 627

  Fly   805 HKMLTFQLATHGS----EKRMRVFLDDLLSMPEPGISQFVPKLELMQCVLDTL--KPHSEWNRLH 863
            ..........|.|    |:.:...:..:..||    :|.:| ::|.|....|.  .|.....|..
plant   628 EDKAASATVVHSSNSVEEEPLTASVQTVSMMP----TQVMP-VKLDQATNSTTVDVPVLSTRRTK 687

  Fly   864 SEYTELLKECKSERQKDIFATPAPPQQKTASSAGSSPR-SGEATGEEVTEKDGATAVAAAVVAGS 927
            |....::.....  :....||..||...|.....|:.. :.:.:|  ||.| ..|..:.|.|...
plant   688 STPVRVMPVVLG--RDTSMATDTPPVTSTRPDRTSATNLTSDVSG--VTSK-RQTRTSPAPVMPM 747

  Fly   928 RMAVTT---GTSTTTTTTASSSLSSSGSSSSTSGSGSSSSSSSTSSLSVPQ-------------P 976
            .:..||   ....:.|:|.....|::..:|..||..||..:.::.:..:|.             |
plant   748 ILNQTTKMKSDEPSITSTWPDRTSATDLTSDVSGVISSRQTRTSPAPVMPMKLNQKTKIKSDEPP 812

  Fly   977 APSLSPEIQTLDSPTVCIDDEILSASSSLPPLDTSPVEVSPA-----------STSGGAASTSP- 1029
            ..|..|:   ..|.|....||  |..:|.....|||..|:|.           |......||.|
plant   813 ITSTRPD---RPSATNLTSDE--SPVTSTRQAKTSPAPVTPVILNQRQTTNMKSDEPPVISTRPL 872

  Fly  1030 --------------AASVAGSAPVSSSKTDQT 1047
                          |::.....|:|||::.:|
plant   873 RTSSARVMPVILNQASTTYDERPLSSSRSART 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	72/330 (22%)
		WD40	14..349	CDD:238121	69/309 (22%)
		WD40 repeat	16..68	CDD:293791
		WD40 repeat	74..127	CDD:293791	9/53 (17%)
		WD40 repeat	132..169	CDD:293791	6/36 (17%)
		WD40 repeat	176..211	CDD:293791	13/34 (38%)
		WD40 repeat	223..263	CDD:293791	8/39 (21%)
		WD40 repeat	275..322	CDD:293791	13/62 (21%)
		WD40 repeat	328..350	CDD:293791	6/31 (19%)
		HIRA_B	423..442	CDD:286531	5/18 (28%)
		Hira	629..820	CDD:284895	37/208 (18%)
DWA3	NP_176316.4	WD40	8..260	CDD:238121	65/289 (22%)
		WD40 repeat	19..56	CDD:293791	9/53 (17%)
		WD40 repeat	61..97	CDD:293791	6/36 (17%)
		WD40 repeat	104..139	CDD:293791	13/34 (38%)
		WD40 repeat	145..181	CDD:293791	8/39 (21%)
		WD40 repeat	187..222	CDD:293791	11/50 (22%)
		WD40 repeat	229..252	CDD:293791	4/22 (18%)
		Herpes_BLLF1	<670..>908	CDD:282904	52/245 (21%)
		Katanin_con80	1024..1175	CDD:404758
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910