DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and AT1G11160

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_172582.2	Gene:	AT1G11160 / 837657	AraportID:	AT1G11160	Length:	1021	Species:	Arabidopsis thaliana

Alignment Length:	981	Identity:	195/981 - (19%)
Similarity:	309/981 - (31%)	Gaps:	386/981 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIW- 97
            |:..|.:.:|            |.:..||:.....|.:..:.|.:...|:.|||||.|..:.:|
plant    76 GASSGVIKLW------------DLEESKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDTNLRVWD 128

  Fly    98 -RKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQA- 160
             ||..                   |..|.:||...:..:.:||:..::.|..:||.|.:||..|
plant   129 TRKKG-------------------CIQTYKGHTRGISTIEFSPDGRWVVSGGLDNVVKVWDLTAG 174

  Fly   161 -FPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGT---- 220
             ..|.   .|.|.|.::.:.:.||...||:.|.||::|.|:          .|.||..|.|
plant   175 KLLHE---FKCHEGPIRSLDFHPLEFLLATGSADRTVKFWD----------LETFELIGTTRPEA 226

  Fly   221 THILRLSWSPDGQYLVSAHAMNGGGPT---AQIIERE----GWKCDKDF-VGHRKAVTCVRFHNS 277
            |.:..:::.||||.|..  .::.|...   ..:|.|:    ||....|| :...|.:.|..:.||
plant   227 TGVRAIAFHPDGQTLFC--GLDDGLKVYSWEPVICRDGVDMGWSTLGDFCINEGKFIGCSYYRNS 289

  Fly   278 I------LSRQENDGSPSKPLQYCCL-----------AVGSRDR------------------SLS 307
            :      :|..|..|:.|:....|.:           .:||..|                  |..
plant   290 VGIWVSDISELEPYGAVSEDKNECMVKRFSVLNDQSERMGSGPRGSVSPDYETREIKNIYVDSTG 354

  Fly   308 VWMTALQRP--------------MVVIHELFNASIL------------------DLTWGPQECLL 340
            ..:...|.|              ..::.|..||:..                  :.::..:|.:.
plant   355 GNLNVAQNPGSLKATLPLESGKVATMVSEKQNAAYFGPAGDKYSSTSRDSDSGEESSYSERESIP 419

  Fly   341 MACSVDGSI--------ACLKF------------TEEELGKAISEE---------EQNA------ 370
            .:.:..|.:        ...||            |.::.|.|:.||         ||||
plant   420 FSRTKSGMLLRPAHVRKTLAKFEESKQSAVVQSATRKKSGLAVEEEPQTQNAFLSEQNASKPFDA 484

  Fly   371 ---IIRKMYGKNYVNGLGKSAPVLEHPQRLLLPQGDKPTKFPLSNNNEAN--------------- 417
               ||:.:..| :...| .|.|..:...|:.|    ||.:...|:|::.|
plant   485 EDSIIKGITNK-FEKAL-SSEPPTDEANRMFL----KPPRIHRSSNSKYNDTRRAMSADPATFGK 543

  Fly   418 ----------------------QRPISKQTETRTKDGKRRITPMFIPLHEDGPTSLSMNIVS--- 457
                                  ::|..:|..|....|.|.:.|:.|   .:|     :|:||
plant   544 GGMENSGDVEDIPSKTERVLSREKPGDEQKNTEYPSGSRELNPVKI---VEG-----VNVVSGRT 600

  Fly   458 ---------------SSGSSTTALTSCSAA----------IGTLPAAAPTESAATP--LMPLEPL 495
                           :.|:|||...:.:|.          .|..|..:...:.:||  :||
plant   601 RSLVEKFERGEKTTHTEGASTTIEQNNNAVQEDPRKTSRQTGETPVISTRRARSTPARVMP---- 661

  Fly   496 VSKIDLGRLDSRLK------TQPASQRRQSLPFDP----GQSNELLRTPRLEEHQSSTCS----- 545
               |.|.| ||.:.      ||||  |..|.|..|    ..||.....|.:...|.|..|
plant   662 ---IVLNR-DSNVTSDEPPLTQPA--RTSSFPVMPVILNQASNVTYDEPSVALTQESRTSHARIL 720

  Fly   546 PSNLNVTATGKSEFVKAALDYRLHVSNGHLKTQHGMLAKVTASDSKEMLWEFYVGSPLVNLNLCE 610
            |...|......||  :|::..|....|...:.:..:|::.|:.:
plant   721 PVTFNQATNITSE--EASVTLRRQRRNSAARVRPVLLSQATSHE--------------------- 762

  Fly   611 KYAMLCSLDGSMRLISMETGCPV--------FPA----------ISLTSSAVHCA----FSPDNS 653
                                |||        .||          :::||...|.|    .||...
plant   763 --------------------CPVTSVRPLRTSPARVMPTKLNQSVNMTSDTSHIASMHRVSPTQM 807

  Fly   654 LVGVLTECGLLRIWDIAKKVVSLAAGCLELLNKHGTAAQFSVTNQGM---PLIGFPSGNS----- 710
            |.              ...|:...|. :.|...|.|..|.:..|...   |.|.....:|
plant   808 LA--------------TPTVIDQVAD-MTLDETHATQIQPACDNMPQKEEPNISDREDDSDITEN 857

  Fly   711 -----YSYSTSLQSWLVLATKDAIMYH--------GIRGTLPRDMDQ---------MQQKFPLLS 753
                 ..:.::|||.|   ||..|:.|        |..|.|.:..||         :.:|..:|:
plant   858 LMLTHNEFLSTLQSRL---TKLQIVRHFWERSDVKGAIGALRKLTDQSVQADVISILTEKIEILT 919

  Fly   754 MQASSQ 759
            :...||
plant   920 LDMFSQ 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	91/447 (20%)
		WD40	14..349	CDD:238121	82/397 (21%)
		WD40 repeat	16..68	CDD:293791	6/33 (18%)
		WD40 repeat	74..127	CDD:293791	13/54 (24%)
		WD40 repeat	132..169	CDD:293791	10/38 (26%)
		WD40 repeat	176..211	CDD:293791	9/34 (26%)
		WD40 repeat	223..263	CDD:293791	12/47 (26%)
		WD40 repeat	275..322	CDD:293791	13/95 (14%)
		WD40 repeat	328..350	CDD:293791	2/47 (4%)
		HIRA_B	423..442	CDD:286531	5/18 (28%)
		Hira	629..820	CDD:284895	39/183 (21%)
AT1G11160	NP_172582.2	WD40	3..253	CDD:238121	56/222 (25%)
		WD40	<7..310	CDD:225201	70/279 (25%)
		WD40 repeat	19..56	CDD:293791
		WD40 repeat	61..97	CDD:293791	6/32 (19%)
		WD40 repeat	104..139	CDD:293791	13/53 (25%)
		WD40 repeat	145..181	CDD:293791	10/38 (26%)
		WD40 repeat	187..222	CDD:293791	13/44 (30%)
		WD40 repeat	229..254	CDD:293791	6/26 (23%)
		Katanin_con80	864..1015	CDD:290636	17/65 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910