DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and HOS15

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_201533.1	Gene:	HOS15 / 836867	AraportID:	AT5G67320	Length:	613	Species:	Arabidopsis thaliana

Alignment Length:	351	Identity:	91/351 - (25%)
Similarity:	148/351 - (42%)	Gaps:	74/351 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KQIFSVDIHKDCTKFATGGQGSDC-GRVVIWNLLPVLSDKAEFDADVPKMLCQMDQHLACVNCVR 77
            |.:.::|.:.:.|..|||    .| |:..||.|             ..:::..:.:|...:..::
plant   325 KDVTTLDWNGEGTLLATG----SCDGQARIWTL-------------NGELISTLSKHKGPIFSLK 372

  Fly    78 WSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDV 142
            |::.|..|.:||.|:..::|...|               |.||..:..  |.|..||:.|. |:|
plant   373 WNKKGDYLLTGSVDRTAVVWDVKA---------------EEWKQQFEF--HSGPTLDVDWR-NNV 419

  Fly   143 YLASCSIDNTVIIWD-AQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSL 206
            ..|:.|.|:.:.:.. .:..|  ..|..||.|.|..|.|||.|..|||.|||.:.||||....:.
plant   420 SFATSSTDSMIYLCKIGETRP--AKTFTGHQGEVNCVKWDPTGSLLASCSDDSTAKIWNIKQSTF 482

  Fly   207 SHTITEPFEECGGTTHILRLSWSPDG--------QYLVSAHAMNGGGPTAQIIEREGWKCDKDFV 263
            .|.:.|      .|..|..:.|||.|        |..:::.:.:.   |.::.:.|..|....|.
plant   483 VHDLRE------HTKEIYTIRWSPTGPGTNNPNKQLTLASASFDS---TVKLWDAELGKMLCSFN 538

  Fly   264 GHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVWMTALQRPMVVIHELFNASI 328
            |||:.|..:.|            ||:.  :|  :|.||.|:|:.:|  :::...:|.....|..|
plant   539 GHREPVYSLAF------------SPNG--EY--IASGSLDKSIHIW--SIKEGKIVKTYTGNGGI 585

  Fly   329 LDLTWGPQECLLMACSVDGSIACLKF 354
            .::.|..:...:.||..|.|:..|.|
plant   586 FEVCWNKEGNKIAACFADNSVCVLDF 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	91/351 (26%)
		WD40	14..349	CDD:238121	88/344 (26%)
		WD40 repeat	16..68	CDD:293791	10/52 (19%)
		WD40 repeat	74..127	CDD:293791	11/52 (21%)
		WD40 repeat	132..169	CDD:293791	10/37 (27%)
		WD40 repeat	176..211	CDD:293791	16/34 (47%)
		WD40 repeat	223..263	CDD:293791	9/47 (19%)
		WD40 repeat	275..322	CDD:293791	10/46 (22%)
		WD40 repeat	328..350	CDD:293791	6/21 (29%)
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
HOS15	NP_201533.1	LisH	8..32	CDD:369916
		WD40	258..569	CDD:238121	81/307 (26%)
		WD40 repeat	269..313	CDD:293791
		WD40 repeat	327..363	CDD:293791	10/52 (19%)
		WD40 repeat	369..405	CDD:293791	11/50 (22%)
		WD40 repeat	410..445	CDD:293791	10/37 (27%)
		WD40 repeat	452..487	CDD:293791	16/34 (47%)
		WD40 repeat	493..538	CDD:293791	9/47 (19%)
		WD40 repeat	544..580	CDD:293791	12/53 (23%)
		WD40 repeat	585..608	CDD:293791	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910