DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and WDR5b

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_192182.1	Gene:	WDR5b / 828189	AraportID:	AT4G02730	Length:	333	Species:	Arabidopsis thaliana

Alignment Length:	394	Identity:	85/394 - (21%)
Similarity:	144/394 - (36%)	Gaps:	116/394 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TGGQGSDCGRVVIWNLLPVLSDKAEFDADVP-----KMLCQMDQHLACVNCVRWSQNGQNLASGS 89
            :||.|:..| |...|    .:..|....:||     :.|..::.|.|.::||::|.:|..|||.|
plant     3 SGGNGTSNG-VANAN----STGNAGTSGNVPIYKPYRHLKTLEGHTAAISCVKFSNDGNLLASAS 62

  Fly    90 DDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVI 154
            .||.:::|..:                 ::...:...||...:.|||||.:..|..|.|.|.|:.
plant    63 VDKTMILWSAT-----------------NYSLIHRYEGHSSGISDLAWSSDSHYTCSASDDCTLR 110

  Fly   155 IWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGG 219
            ||||::....:..|:|||..|..|:::|....:.|.|.|.:|:||..........|
plant   111 IWDARSPYECLKVLRGHTNFVFCVNFNPPSNLIVSGSFDETIRIWEVKTGKCVRMI--------- 166

  Fly   220 TTHILRLS---WSPDGQYLVSA--------------------------------HAMNGG----- 244
            ..|.:.:|   ::.||..:|||                                .:.||.
plant   167 KAHSMPISSVHFNRDGSLIVSASHDGSCKIWDAKEGTCLKTLIDDKSPAVSFAKFSPNGKFILVA 231

  Fly   245 --GPTAQIIEREGWKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLS 307
              ..|.::......|..|.:.||...|.|:....|:.:.:             .:..||.|..:.
plant   232 TLDSTLKLSNYATGKFLKVYTGHTNKVFCITSAFSVTNGK-------------YIVSGSEDNCVY 283

  Fly   308 VWMTALQRPMVVIHELFNASILDLTWGPQECLLMACSVDGSIAC------LKFTEEELGKAISEE 366
            :|            :|...:||....|..:.::       |::|      :..:...|.|.|...
plant   284 LW------------DLQARNILQRLEGHTDAVI-------SVSCHPVQNEISSSGNHLDKTIRIW 329

  Fly   367 EQNA 370
            :|:|
plant   330 KQDA 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	84/392 (21%)
		WD40	14..349	CDD:238121	78/365 (21%)
		WD40 repeat	16..68	CDD:293791	10/42 (24%)
		WD40 repeat	74..127	CDD:293791	11/52 (21%)
		WD40 repeat	132..169	CDD:293791	14/36 (39%)
		WD40 repeat	176..211	CDD:293791	8/34 (24%)
		WD40 repeat	223..263	CDD:293791	11/81 (14%)
		WD40 repeat	275..322	CDD:293791	5/46 (11%)
		WD40 repeat	328..350	CDD:293791	4/21 (19%)
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
WDR5b	NP_192182.1	WD40	26..>330	CDD:225201	76/361 (21%)
		WD40	35..330	CDD:238121	74/352 (21%)
		WD40 repeat	46..83	CDD:293791	11/53 (21%)
		WD40 repeat	89..126	CDD:293791	15/36 (42%)
		WD40 repeat	131..167	CDD:293791	10/44 (23%)
		WD40 repeat	174..209	CDD:293791	6/34 (18%)
		WD40 repeat	216..252	CDD:293791	5/35 (14%)
		WD40 repeat	260..297	CDD:293791	9/61 (15%)
		WD40 repeat	303..329	CDD:293791	5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910