Protein Alignment Hira and HIRA

DIOPT Version :10

• Sequence 1: NP_572401.2
• Gene: Hira / 31680
• FlyBaseID: FBgn0022786
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_190039.2
• Gene: HIRA / 823578
• AraportID: AT3G44530
• Length: 1058
• Species: Arabidopsis thaliana
• Alignment Length: 1152
• Identity: 296/1152 - (25%)
• Similarity: 468/1152 - (40%)
• Gaps: 287/1152 - (24%)

  Fly     5 KPAWVHHDDKQIFSVDIHKDCTKFATGGQGSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQMDQH 69
            ||.||.|:..||||:|:..:..:|||||...   :|.|||:..|..|....|.. .::|..:..|
plant     5 KPFWVKHEGLQIFSIDVQPNGERFATGGGDH---KVRIWNMKSVDKDLQNIDTK-ERLLATLRDH 65

  Fly    70 LACVNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGV-FGTGGMQKNHESWKCFYTLRGHDGDVL 133
            ...||||||::|.:.:||||||::|.|..:..||... ||: |...:.|:||...|||||..||:
plant    66 FGSVNCVRWAKNSRYVASGSDDQVIQIHERKPGSGTTEFGS-GEAPDVENWKAVMTLRGHTADVV 129

  Fly   134 DLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKI 198
            ||.|||:|..|||.|:||||.||:.:. ......|:||..|||||:|||:|.|:||||||:::.|
plant   130 DLNWSPDDSMLASGSLDNTVHIWNMRT-GMCTTVLRGHLSLVKGVTWDPIGSFIASQSDDKTVII 193

  Fly   199 WNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDKDFV 263
            |.|.:|.::|.....:.:..|:|...||.|||.|.:|.:.|.......:|.::||..|....||:
plant   194 WRTSDWGMAHRTDGHWAKSLGSTFFRRLGWSPCGHFLTTTHGFQKPKHSAPVLERGEWSVAYDFL 258

  Fly   264 GHRKAVTCVRFHNSILSR------------QENDGSPS--KPLQ-YCCLAVGSRDRSLSVWMTAL 313
            ||...:..|||::|:..|            ..|..|.|  |.|| |..:|:||:||:::||.|..
plant   259 GHSAPIIVVRFNHSMFKRIPSSTHETKQVGWSNGTSKSGEKDLQSYNVIAMGSQDRTITVWTTGS 323

  Fly   314 QRPMVVIHELFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEEQNAIIRKMYGK 378
            .||:.|....|..|::||:|.|....|.|||:||::|.:.|..:|||..:::.|.:.:.:..||
plant   324 ARPLFVAKHFFGQSVVDLSWSPDGYSLFACSLDGTVAMIHFDPKELGVRLTDTELDELKKSRYG- 387

  Fly   379 NYVNGLGKSAPVLEHPQRLLL-----------------PQGDKPTKFPLSNNNEANQRPISKQTE 426
               :..|:.|.::|.|.:|||                 .|....||..:|..:.|.:|  ..|.:
plant   388 ---DVRGRQANLVESPAQLLLETASTKQAGSKRAASDVQQNQVTTKPSVSVESTAKRR--KSQVD 447

  Fly   427 TRTK------------------------------DGKRRITP--MFIPLHEDGPTSLSMNIVSSS 459
            .|.|                              ||::||.|  :.:|..|        |.:..:
plant   448 DRNKAAESTGQTLNKASTLNRVSSPVNQKVYRRPDGRKRIIPEAVGVPQQE--------NNIMIN 504

  Fly   460 GSSTTALTSCSAAIGTLPAAA-----PTESAATPLMPLEPLVSKIDL---GRLDSR--------L 508
            |.|...|.:.:||    ||..     |.|.:...|...|.:....||   .|:.:|        :
plant   505 GESHNFLPASAAA----PAKGDSGDFPVEISNRDLSGKEIVCRNPDLKERSRITARATITESLVI 565

  Fly   509 KTQPASQRR-------QSLPFDPGQSNELLRTPRLEEHQSSTCSPSNLNVTATGKSEFVKAALDY 566
            :..|.:..|       ||:......|.:||  .|:.:.:....:|. :.:.|..:..    |||.
plant   566 EKVPGTSGRDGVLNVEQSVGIKESSSTDLL--IRVFDWKDGEAAPP-VCLEACPREH----ALDT 623

  Fly   567 RLHVSNGHLKTQHGMLAKVTASDSKEMLWE--------FYVGSPLVNLNLCEKYAMLCSLDGSMR 623
            ...||...:|.     .:::...|.|.||.        ...|:|......||        |||::
plant   624 VGAVSTSMVKE-----TEISCKKSGETLWSDRIMGRVTVLAGNPNFWAAGCE--------DGSLQ 675

  Fly   624 LISMETGCPVFPAISLTSSA--VHCAFSPDNSLVGVLTECGLLRIWDIAKK-------VVSLAAG 679
            :.: :.|....|.:.:.|:|  :.|   .|:..:.::|..|.|.:||:..:       :.||.:.
plant   676 VYT-KCGRRAMPTMMMGSAATFIDC---DDSWKLLLVTRKGSLYVWDLFNRKCVLHDSLSSLVSS 736

  Fly   680 --------------------------CLELLNKHGTAA-----------QFSVTNQGMPLIGFPS 707
                                      .:|||:.:..::           ...::..|.||:...:
plant   737 DVNLSSTVKVKRMKNWYLLIFLVGDLVVELLSWYEDSSVIDLDCTIKVISVKLSKSGSPLVVLAT 801

  Fly   708 GNSYSYSTSLQSWLVLATK--------------------------DAIMYHGIRGTLPRDMDQMQ 746
            .:::.:.|||..||.:|..                          |...|...:....|..|...
plant   802 RHAFLFDTSLMCWLRVADDCFPASNFSSSWNLGSAPCGELAGLQVDVRKYMARKPGWNRITDDGT 866

  Fly   747 QKFPLLSMQASSQNYFSFTGSMELRHSESWQQC--AKIRFIENQIKLCEALQSLDELQHWHKMLT 809
            |....|..|.:|        |:.|.....::||  |.:||
plant   867 QTRAHLESQLAS--------SLALESPNEYRQCLLAYVRF------------------------- 898

  Fly   810 FQLATHGSEKRMRVFLDDLLSMPEPGISQF---------------VPKLELMQ-CVLDTLKPHSE 858
              ||....|.|:|...:..|. |..|:::.               |.|.:|:: .:|..:..:.:
plant   899 --LAREADESRLREVCESFLG-PPTGMAEAASSDTNLSWDPYVLGVKKHKLLRNDILPAMASNRK 960

  Fly   859 WNRLHSEYTELLKECKSERQKDIFATPAPPQQKTASSAGSSPRSGEATGEEVTEKDGATAVAAAV 923
            ..||.:|:.:||.|.:.....|    |||.......:.|..|.|.:..|.:          ..|:
plant   961 VQRLLNEFIDLLSEYEDVETAD----PAPKGSTPTMNCGGVPSSLDQIGSD----------PPAM 1011

  Fly   924 VAGSRMAVTTGTSTTTTTTASSSL---SSSGSSSSTSGSGSSSSSSS 967
            .|.:.|.:......:....|:..:   ..:||........:|..|.|
plant  1012 TATTPMTIDNDKPVSLENPAALDIGVCEKTGSEDRDKQDQNSRDSGS 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	14..349	CDD:238121	142/350 (41%)
		WD40 repeat	16..68	CDD:293791	17/51 (33%)
		WD40 repeat	74..127	CDD:293791	24/53 (45%)
		WD40 repeat	132..169	CDD:293791	17/36 (47%)
		WD40 repeat	176..211	CDD:293791	19/34 (56%)
		WD40 repeat	223..263	CDD:293791	13/39 (33%)
		WD40 repeat	275..322	CDD:293791	20/61 (33%)
		WD40 repeat	328..350	CDD:293791	10/21 (48%)
		HIRA_B	424..442	CDD:462802	8/49 (16%)
		Hira	630..828	CDD:462211	45/271 (17%)
HIRA	NP_190039.2	WD40	<3..359	CDD:441893	147/359 (41%)
		WD40 repeat	16..64	CDD:293791	17/51 (33%)
		WD40 repeat	70..123	CDD:293791	24/53 (45%)
		WD40 repeat	128..164	CDD:293791	17/36 (47%)
		WD40 repeat	171..206	CDD:293791	19/34 (56%)
		WD40 repeat	264..331	CDD:293791	23/66 (35%)
		WD40 repeat	338..362	CDD:293791	11/23 (48%)
		Hira	681..915	CDD:462211	45/271 (17%)