DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and AT2G21390

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_179734.1	Gene:	AT2G21390 / 816678	AraportID:	AT2G21390	Length:	1218	Species:	Arabidopsis thaliana

Alignment Length:	1200	Identity:	220/1200 - (18%)
Similarity:	364/1200 - (30%)	Gaps:	457/1200 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VDIHKDCTKFATGGQGSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQMDQHLACVNCVRWSQNGQ 83
            |..|.....|.:||   |..::.:||.            ...:.|..:..||..:..|::.....
plant    57 VHFHNSQPLFVSGG---DDYKIKVWNY------------KTHRCLFTLLGHLDYIRTVQFHHENP 106

  Fly    84 NLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCS 148
            .:.|.|||:.|.||                 |.:|..|...|.||:..|:..::.|.:..:.|.|
plant   107 WIVSASDDQTIRIW-----------------NWQSRTCISVLTGHNHYVMCASFHPKEDLVVSAS 154

  Fly   149 IDNTVIIWDAQAFPHSVAT--------------------------LKGHTGLVKGVSW---DPLG 184
            :|.||.:||..|.....|:                          |:||.   :||:|   .|..
plant   155 LDQTVRVWDIGALKKKSASPADDLMRFSQMNSDLFGGVDAIVKYVLEGHD---RGVNWASFHPTL 216

  Fly   185 RFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQ 249
            ..:.|.:|||.:|:|.                                        ||
plant   217 PLIVSGADDRQVKLWR----------------------------------------MN------- 234

  Fly   250 IIEREGWKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVW----M 310
              |.:.|:.| ...||...|:.|.||    ::|:            .:...|.|:|:.||    .
plant   235 --ETKAWEVD-TLRGHMNNVSSVMFH----AKQD------------IIVSNSEDKSIRVWDATKR 280

  Fly   311 TALQR--------PMVVIHELFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEE 367
            |.:|.        .::.:|...|              |:|...|..:...|...|....|:|.:.
plant   281 TGIQTFRREHDRFWILAVHPEIN--------------LLAAGHDNGMIVFKLERERPAFALSGDS 331

  Fly   368 QNAIIRKMYGKNYVNGLGKSAPVLEHPQRLLLPQGDKPTKFPLSNNNEANQRPISKQTETRTKDG 432
                  ..|.|:                |.|                    |.....|:   ||.
plant   332 ------LFYAKD----------------RFL--------------------RYYEYSTQ---KDS 351

  Fly   433 KRRITPMFIPLHEDGPTSLSMNIVSSSGSSTTALTSCSAAIGTLPAAAPTESAATPLMPLEP--- 494
            :      .||:...|..||:.:..:.|.|                   |||:|......|:.
plant   352 Q------VIPIRRPGTPSLNQSPRTLSYS-------------------PTENAVLICSDLDGGSY 391

  Fly   495 ---LVSKIDLGRLDSRLKTQPASQRRQSLPFDPGQSNELLRTPRLEEHQSSTCSPSNLNVTATGK 556
               ::.|..:||.|   ..|.|.:       ..|.|...:...|....:.||......|:    |
plant   392 ELYIIPKDSVGRSD---VVQDAKR-------GTGGSAVFIARNRFAVLEKSTSQVLVKNL----K 442

  Fly   557 SEFVKAA-----LDYRLHVSNGHLKTQHGMLAKVTASDSKEMLWEFYVGSPLVNL----NLCEKY 612
            :|.||.:     .|...:...|:|..:..  .||...|.::.|....:.:|.|..    |..|..
plant   443 NEVVKKSSLPIPTDAIFYAGTGNLLCRSE--DKVVIFDLQQRLVLGELQTPFVRYVVWSNDMESV 505

  Fly   613 AMLCS---LDGSMRLISMETGCPVFPAISLTSSAVHCAFSPDNSLVGVLT------------ECG 662
            |:|..   :..|.:|:..   |.:...|.:.|.|.      |::.|.:.|            :.|
plant   506 ALLSKHTIIIASKKLVLQ---CTLHETIRVKSGAW------DDNGVFIYTTLNHIKYCLPNGDSG 561

  Fly   663 LLRIWDIAKKVVSLAAGCLELLNKHGTAAQFSVTNQGMPLIGFPSGNSYSYSTSLQSWLVLATKD 727
            ::|..|:...:..::...:..|::.|.....::           :...|.:..:|
plant   562 IIRTLDVPIYITKVSGNTIFCLDRDGKNRAITI-----------NATEYIFKLAL---------- 605

  Fly   728 AIMYHGIRGTLPRDMDQMQQKFP-LLSMQASSQ-------NYFSFTGSMELRHSESWQQCAKIRF 784
                             :::|:. ::||..:||       .|....|..|:          .:.|
plant   606 -----------------LRKKYDHVMSMIKNSQLCGQAMIAYLQQKGFPEV----------ALHF 643

  Fly   785 IENQ-IKLCEALQS------------LDELQHWHKM-------------------------LTF- 810
            :|:: |:...||:|            ::|..||:::                         |:|
plant   644 VEDERIRFNLALESGNISVAVASATEINEKDHWYRLGVEALRQGNSRIVEFAYQQTKNFERLSFL 708

  Fly   811 QLATHGSEKRMRVFLDDLLSMPEPG---ISQFVPKLELMQCVLDTLKPHSEWNRLHSEY------ 866
            .|.|...:|     |..|:.:.|..   :.||...|.|.. |.:.:|.......|...|
plant   709 YLITGNLDK-----LSKLMKIAEVKNNVMGQFHNALYLGD-VKERVKILENAGHLPLAYITASVH 767

  Fly   867 --TELLKECKSERQKDIFATPAPPQQKTAS------------------------SAGSSPRSGEA 905
              |::.:....|...::   |:.|:.||.|                        ..|....:..|
plant   768 GLTDIAERLAIELGDNV---PSLPEGKTPSLLMPPSPIMCGGDWPLLRVMKGIFEGGLESANRGA 829

  Fly   906 TGEEVTEKDG------------------ATAVAAAVVAGSRMAVTTG--------TSTTTTTTAS 944
            ..||..:.:|                  ..|:.....||.......|        .....|..||
plant   830 VDEEEEDVEGDWGEGLDKFDVDGMENTDIEAILDGAEAGEEEDDEEGGWGLDLDLPPELDTPKAS 894

  Fly   945 SSLSSSGSSSSTSGSGSSSSSSSTSSLSVPQPAP-SLSPEIQTLD--------SPTVCIDDEILS 1000
            ::..||...:...|...|...|..|||:..|.|. |....::.|.        :|...:..::.|
plant   895 ANARSSTFVTPPQGMPVSQIWSQKSSLAAEQAAAGSFDTAMRLLHRQLGIKNFAPLKSMFLDLFS 959

  Fly  1001 ASSS-LPPLDTSPVEVSPASTSGGAASTSP 1029
            .|.| |....:||| |..|...|.:.|:||
plant   960 GSHSYLRAFSSSPV-VPLAIERGWSESSSP 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	77/391 (20%)
		WD40	14..349	CDD:238121	73/370 (20%)
		WD40 repeat	16..68	CDD:293791	9/48 (19%)
		WD40 repeat	74..127	CDD:293791	12/52 (23%)
		WD40 repeat	132..169	CDD:293791	11/62 (18%)
		WD40 repeat	176..211	CDD:293791	10/37 (27%)
		WD40 repeat	223..263	CDD:293791	5/39 (13%)
		WD40 repeat	275..322	CDD:293791	9/58 (16%)
		WD40 repeat	328..350	CDD:293791	3/21 (14%)
		HIRA_B	423..442	CDD:286531	3/18 (17%)
		Hira	629..820	CDD:284895	35/249 (14%)
AT2G21390	NP_179734.1	WD40	9..317	CDD:238121	73/374 (20%)
		WD40 repeat	15..49	CDD:293791
		WD40 repeat	55..91	CDD:293791	9/48 (19%)
		WD40 repeat	96..132	CDD:293791	11/52 (21%)
		WD40 repeat	139..201	CDD:293791	10/61 (16%)
		WD40 repeat	207..245	CDD:293791	14/87 (16%)
		WD40 repeat	251..288	CDD:293791	12/52 (23%)
		WD40 repeat	295..316	CDD:293791	5/34 (15%)
		Coatomer_WDAD	337..769	CDD:397941	96/574 (17%)
		COPI_C	816..1212	CDD:399736	37/173 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910