DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hira and Tbl1xr1

DIOPT Version :9

Sequence 1:NP_572401.2 Gene:Hira / 31680 FlyBaseID:FBgn0022786 Length:1047 Species:Drosophila melanogaster
Sequence 2:NP_109657.2 Gene:Tbl1xr1 / 81004 MGIID:2441730 Length:514 Species:Mus musculus


Alignment Length:390 Identity:95/390 - (24%)
Similarity:132/390 - (33%) Gaps:135/390 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 GQGSDCGRVVIWNLLPVLSDKA--------------EFDADVP--KMLCQMDQHLACVNCVRWSQ 80
            |.|....|  |||    ||:.:              |...|||  |.:..:|          |:.
Mouse   187 GSGDSTAR--IWN----LSENSTSGPTQLVLRHCIREGGQDVPSNKDVTSLD----------WNS 235

  Fly    81 NGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVYLA 145
            .|..||:||.|....||.|....:.                  ||..|.|.:..|.|:....::.
Mouse   236 EGTLLATGSYDGFARIWTKDGNLAS------------------TLGQHKGPIFALKWNKKGNFIL 282

  Fly   146 SCSIDNTVIIWDA------QAFP-HS---------------------------------VATLKG 170
            |..:|.|.|||||      |.|| ||                                 :.|.:|
Mouse   283 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQG 347

  Fly   171 HTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYL 235
            ||..|..:.|||.|..|||.|||.::|||:....:..|.:....:|      |..:.|||.|.  
Mouse   348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKE------IYTIKWSPTGP-- 404

  Fly   236 VSAHAMNGGGPTAQIIEREG--------WKCDK-----DFVGHRKAVTCVRFHNSILSRQENDGS 287
                  ....|.|.::....        |..|:     ....|::.|..|.|        ..|| 
Mouse   405 ------GTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAF--------SPDG- 454

  Fly   288 PSKPLQYCCLAVGSRDRSLSVWMTALQRPMVVIHELFNASILDLTWGPQECLLMACSVDGSIACL 352
                 :|  ||.||.|:.:.:|.|  |...:|........|.::.|......:.|.:.|||:..|
Mouse   455 -----RY--LASGSFDKCVHIWNT--QTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVL 510

  Fly   353  352
            Mouse   511  510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HiraNP_572401.2 WD40 <12..370 CDD:225201 95/390 (24%)
WD40 14..349 CDD:238121 93/385 (24%)
WD40 repeat 16..68 CDD:293791 13/51 (25%)
WD40 repeat 74..127 CDD:293791 12/52 (23%)
WD40 repeat 132..169 CDD:293791 16/76 (21%)
WD40 repeat 176..211 CDD:293791 14/34 (41%)
WD40 repeat 223..263 CDD:293791 9/52 (17%)
WD40 repeat 275..322 CDD:293791 12/46 (26%)
WD40 repeat 328..350 CDD:293791 6/21 (29%)
HIRA_B 423..442 CDD:286531
Hira 629..820 CDD:284895
Tbl1xr1NP_109657.2 LisH 7..31 CDD:369916
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..139
WD40 164..470 CDD:238121 84/346 (24%)
WD 1 167..206 8/24 (33%)
WD40 repeat 172..215 CDD:293791 8/33 (24%)
WD 2 223..262 13/66 (20%)
WD40 repeat 228..264 CDD:293791 13/63 (21%)
WD 3 264..303 12/38 (32%)
WD40 repeat 270..306 CDD:293791 12/35 (34%)
WD 4 306..344 2/37 (5%)
WD40 repeat 311..346 CDD:293791 1/34 (3%)
WD 5 347..386 17/38 (45%)
WD40 repeat 353..388 CDD:293791 14/34 (41%)
WD 6 389..437 10/61 (16%)
WD40 repeat 394..439 CDD:293791 9/52 (17%)
TolB <436..>514 CDD:392172 23/93 (25%)
WD 7 440..479 16/56 (29%)
WD40 repeat 445..483 CDD:293791 15/55 (27%)
WD 8 481..513 7/30 (23%)
WD40 repeat 486..509 CDD:293791 6/22 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.