DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and HIRA

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_003316.3	Gene:	HIRA / 7290	HGNCID:	4916	Length:	1017	Species:	Homo sapiens

Alignment Length:	1035	Identity:	377/1035 - (36%)
Similarity:	541/1035 - (52%)	Gaps:	189/1035 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLLKPAWVHHDDKQIFSVDIHKDCTKFATGGQGSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQ 65
            |:||||.||:|:.|.|||||||.|.|||||||||.|.|:|||||:.|||.:..|.|.::||||||
Human     1 MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQ 65

  Fly    66 MDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSA--GSSGVFGTGGMQKNHESWKCFYTLRGH 128
            ||.|||||||||||.:|..||||.||||||:|:::.  |.|.|||:.|...|.|.|:|...||.|
Human    66 MDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNH 130

  Fly   129 DGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDD 193
            .|||:|:||||:|.:|||||:||||:||:|..||..:|||:||:|||||::|||:|:::|||:||
Human   131 SGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADD 195

  Fly   194 RSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKC 258
            ||:|:|.|::|.|..:||:||:|||||||:|||||||||.|||||||||..|||||||||||||.
Human   196 RSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKT 260

  Fly   259 DKDFVGHRKAVTCVRFHNSILSRQENDGSPSKP-LQYCCLAVGSRDRSLSVWMTALQRPMVVIHE 322
            :.||||||||||.|:|:..|..:::.:||.:|| ..|||.||||:|||||||:|.|:||:|||||
Human   261 NMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHE 325

  Fly   323 LFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEEQNAIIRKMYGKN--YVNGLG 385
            ||:.||:|::|......::.||:|||:|.|.|:::|||..:||||::.|.:..|||:  .:....
Human   326 LFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQ 390

  Fly   386 KSAPVLEHPQRLLLPQGDKPTKFPLSN----------------NNEA----NQRPISKQTETRTK 430
            .|..|:|:|:.|...:..:..:....:                |.|:    .:..:.||.||||.
Human   391 LSTAVIENPEMLKYQRRQQQQQLDQKSAATREMGSATSVAGVVNGESLEDIRKNLLKKQVETRTA 455

  Fly   431 DGKRRITPM------------------------------------FIPLHEDGPTSL-------- 451
            ||:|||||:                                    .:||....|.|.
Human   456 DGRRRITPLCIAQLDTGDFSTAFFNSIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTE 520

  Fly   452 ------------SMNIVSSSGSSTTALTSCSAAIGTLPA--------------------AAPTES 484
                        |:|..|.:.:||.|  :.|.::.|.|:                    .||..:
Human   521 PVVAASARPAGDSVNKDSMNATSTPA--ALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALT 583

  Fly   485 AATP--------------LMPLEPLVSKIDLGRLDSRLKTQPASQRRQSLPFDPGQSNELLRTPR 535
            :.||              |.|.:.|.|..|........|....|:|:..|..:..:..:..| ||
Human   584 SMTPTAVERLKEQNLVKELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVETVEKKKKGR-PR 647

  Fly   536 LEEHQSSTCSPSNLNVTATGKSEFVKAAL------------------DYRLHVSNG---HLKTQH 579
                :.|...|.:|:|.:.......|.|:                  .:.|.||:.   :::.::
Human   648 ----KDSRLMPVSLSVQSPAALTAEKEAMCLSAPALALKLPIPSPQRAFTLQVSSDPSMYIEVEN 708

  Fly   580 GM-------LAKVTAS-DSKEMLWEFYVGSPLVN-LNLCEKYAMLCSLDGSMRLISMETGC--PV 633
            .:       |:::..: :.||  ||..:.|.::. ...|:...:.|    ..|::|:.:.|  .:
Human   709 EVTVVGGVKLSRLKCNREGKE--WETVLTSRILTAAGSCDVVCVAC----EKRMLSVFSTCGRRL 767

  Fly   634 FPAISLTS--SAVHCAFSPDNSLVGVLTECGLLRIWDIAKKVVSLAAGCLE--LLNKHGTAAQFS 694
            ...|.|.|  |.:||.    .|.|..||....|.:||:.::||.:....|.  |.....|.:|..
Human   768 LSPILLPSPISTLHCT----GSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGSDMTVSQIL 828

  Fly   695 VTNQGMPLIGFPSGNSYSYSTSLQSWLVLATKDAIMYH--GIRGTLPRDMDQMQQKFPLLSMQAS 757
            :|..|:|::....|.:|.::.||.:|.:::.|...:..  ..|.:|| ..|.|....||..:|..
Human   829 LTQHGIPVMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLP-SQDAMLCSGPLAIIQGR 892

  Fly   758 SQNYFSFTGSMELR-----HSESWQQCAKIRFIENQIKLCEALQSLDELQHWHKMLTFQLATHGS 817
            :.|    :|....|     |..  ||...:.::|||:.....|||..|.:||..:....|...|.
Human   893 TSN----SGRQAARLFSVPHVV--QQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGF 951

  Fly   818 EKRMRVFLDDLLSMPEPGI-SQF------VPKLELMQCVLDTLKPHSEWNRLHSEYTELL 870
            |.|:|....|||....... ||:      :.|.||::.:|..:..:..:.||.:|..|.|
Human   952 EYRLREICKDLLGPVHYSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQL 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	226/360 (63%)
		WD40	14..349	CDD:238121	215/337 (64%)
		WD40 repeat	16..68	CDD:293791	36/51 (71%)
		WD40 repeat	74..127	CDD:293791	29/54 (54%)
		WD40 repeat	132..169	CDD:293791	23/36 (64%)
		WD40 repeat	176..211	CDD:293791	18/34 (53%)
		WD40 repeat	223..263	CDD:293791	32/39 (82%)
		WD40 repeat	275..322	CDD:293791	26/47 (55%)
		WD40 repeat	328..350	CDD:293791	8/21 (38%)
		HIRA_B	423..442	CDD:286531	13/54 (24%)
		Hira	629..820	CDD:284895	55/203 (27%)
HIRA	NP_003316.3	WD40	<7..372	CDD:225201	229/364 (63%)
		WD40	7..352	CDD:238121	218/344 (63%)
		WD 1	11..53		29/41 (71%)
		WD40 repeat	16..61	CDD:293791	29/44 (66%)
		WD 2	68..107		24/38 (63%)
		WD40 repeat	74..129	CDD:293791	29/54 (54%)
		WD 3	129..168		24/38 (63%)
		WD40 repeat	134..171	CDD:293791	23/36 (64%)
		WD 4	172..211		23/38 (61%)
		WD40 repeat	178..213	CDD:293791	18/34 (53%)
		WD 5	220..263		36/42 (86%)
		WD40 repeat	226..265	CDD:293791	32/38 (84%)
		WD 6	266..322		32/55 (58%)
		WD40 repeat	273..324	CDD:293791	27/50 (54%)
		WD 7	326..367		17/40 (43%)
		WD40 repeat	331..354	CDD:293791	8/22 (36%)
		Interaction with CCNA1. /evidence=ECO:0000269\|PubMed:11238922	421..729		54/314 (17%)
		Interaction with ASF1A	421..479		15/57 (26%)
		Required for repression of histone gene transcription	439..475		13/35 (37%)
		HIRA_B	448..469	CDD:286531	13/20 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..555		11/62 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..589		4/18 (22%)
		Interaction with histone H2B	593..826		50/247 (20%)
		Interaction with PAX3. /evidence=ECO:0000250	594..739		27/151 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	604..625		5/20 (25%)
		Mcl1_mid	<727..>795	CDD:289138	20/77 (26%)
		Interaction with histone H4	738..1017		75/289 (26%)
		Interaction with PAX3. /evidence=ECO:0000250	740..828		24/95 (25%)
		Hira	763..954	CDD:284895	55/201 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151921
Domainoid	1	1.000	69	1.000	Domainoid score	I9702
eggNOG	1	0.900	-	-		E1_KOG0973
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48172
Inparanoid	1	1.050	622	1.000	Inparanoid score	I875
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	1	1.000	-	-		FOG0003162
OrthoInspector	1	1.000	-	-		oto88549
orthoMCL	1	0.900	-	-		OOG6_103167
Panther	1	1.100	-	-	LDO	PTHR13831
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R561
SonicParanoid	1	1.000	-	-		X3052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790