DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and hira

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_696478.2	Gene:	hira / 568076	ZFINID:	ZDB-GENE-030131-6296	Length:	1010	Species:	Danio rerio

Alignment Length:	1032	Identity:	382/1032 - (37%)
Similarity:	540/1032 - (52%)	Gaps:	188/1032 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLLKPAWVHHDDKQIFSVDIHKDCTKFATGGQGSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQ 65
            |:||||:||:|:.|.|||||||.|.|||||||||.|.|:|||||:.|||.::.|.:.::||:|||
Zfish     1 MKLLKPSWVNHNGKPIFSVDIHPDGTKFATGGQGEDSGKVVIWNMAPVLREEDEKNENIPKLLCQ 65

  Fly    66 MDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSA--GSSGVFGTGGMQKNHESWKCFYTLRGH 128
            ||.|||||||||||.||..||||.||||:|:|:::|  |.|.|||:.....|.|.|:|...||.|
Zfish    66 MDNHLACVNCVRWSNNGLYLASGGDDKLVMVWKRAAFIGPSTVFGSSSKLANVEQWRCVTILRNH 130

  Fly   129 DGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDD 193
            .|||:|:||||:||:|||||:|||::||:|:.||..|.|||||||||||::|||:|:::|||:||
Zfish   131 TGDVMDVAWSPHDVWLASCSVDNTIVIWNARKFPEIVMTLKGHTGLVKGLTWDPVGKYIASQADD 195

  Fly   194 RSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKC 258
            .|:|:|.||:|.|...||:||.|||||||:|||||||||||||||||||..|||||||||:|||.
Zfish   196 HSLKVWRTMDWQLETNITKPFSECGGTTHVLRLSWSPDGQYLVSAHAMNNSGPTAQIIERDGWKT 260

  Fly   259 DKDFVGHRKAVTCVRFHNSILSRQENDGSPSKP-LQYCCLAVGSRDRSLSVWMTALQRPMVVIHE 322
            :.||||||||||.|:|:..|..:::.:||..|| ..|||.||||:|||||||:|:|:||:||||:
Zfish   261 NMDFVGHRKAVTVVKFNPKIFKKKQKNGSTPKPSCPYCCCAVGSKDRSLSVWLTSLKRPLVVIHD 325

  Fly   323 LFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEEQNAIIRKMYGKNYVNGLGK- 386
            ||:.||:|:||......|:.||:||::|.|.|:::|||..::|||:|||.:.:|||:....:..
Zfish   326 LFDKSIMDITWTLNGLGLLVCSMDGTVAFLDFSQDELGDPLNEEEKNAIHQNIYGKSLAITMESQ 390

  Fly   387 -SAPVLEHPQRLLLP---QGDKPTKFPLSNNNEANQRP------------------ISKQTETRT 429
             |..::|:|:.|...   ||::.......:..| ||.|                  :.||.||||
Zfish   391 LSTTIIENPEMLKYQQERQGNQNANVAQGSGPE-NQTPKLTNVLNGESLEDIRKNLLKKQVETRT 454

  Fly   430 KDGKRRITPMFIPLHEDGPTS----LSMNIVSSSGSSTTALTSCSA------AIGTLPAAAPT-- 482
            .||:|||||:.|...:.|..|    .|:.|:..|.:||......|:      ::|..|:..|:
Zfish   455 ADGRRRITPLCIAQLDTGDFSPALFNSVPILPGSSASTQLTPQISSDSNTANSLGLRPSHDPSTT 519

  Fly   483 ----------ESAATPLMP-------LEPLVSKID-LGRLDSRLKTQPASQRRQS---------- 519
                      :||..|:..       |....|||: :..||||.     ::|.::
Zfish   520 SPNKTAEENKDSATAPVNSIGMKSTLLLTSASKIEPMKALDSRF-----TERSKATPGVTSVPIT 579

  Fly   520 ---LPFDPGQSNELLRTPRLEEHQSSTCSPSNLNVT---ATGKSEF------------------- 559
               .|.|..:.:..::.|:.::..||......:|.|   |..|.|.
Zfish   580 IGITPLDRAKDSSSVKEPKGKDETSSDSEDKIMNKTLSMAKRKGEIEGGEVVEKRKKGRPRKDAK 644

  Fly   560 ---------------VKAALDYRLHVSNGHLK-----------TQHGM-----------LAKVTA 587
                           ||..|. ||......||           ||.|.           ::.|:.
Zfish   645 MMMPISQPFPQTPVSVKEELP-RLATPAVVLKLPTPSIQKSFSTQVGTDAVTYLEVENEVSVVSG 708

  Fly   588 SDSKEMLWE---------------FYVGSPLVNLNLCEKYAMLCSLDGSMRLISMETGC--PVFP 635
            :...::.|.               ...||..|....||.           |.:|:.|.|  .:.|
Zfish   709 ARLSQLKWRREGREWDTLLPSRIIIATGSSDVVAVACED-----------RTLSVFTACGRRLIP 762

  Fly   636 AISLTS--SAVHCAFSPDNSLVGVLTECGLLRIWDIAKKVVSLAAGCLE--LLNKHGTAAQFSVT 696
            :|.|.:  ||:||:    ...|..|.....|.:||:.|:...:....|.  |.....|.:|..:|
Zfish   763 SIMLPAPMSALHCS----GHFVMALMASATLSVWDVQKQTALVKNESLNPILSGTDATVSQSLIT 823

  Fly   697 NQGMPLIGFPSGNSYSYSTSLQSWLVLATK--DAIMYHGIRGTLPRDMDQMQQKFPLLSMQASSQ 759
            .||:.::...:|.:|.:::||::|.::|.|  ..:.....|..| ...|.:....||...|..:.
Zfish   824 QQGVAVVSLSNGKTYCFNSSLETWNLIADKQDSLVQCADFRNCL-SSQDVLGSMGPLALTQGRNL 887

  Fly   760 NYFSFTGSMELRHSES---WQQCAKIRFIENQIKLCEALQSLDELQHWHKMLTFQLATHGSEKRM 821
            :    .|.:..|.|.:   .||...:.|:|||:.....|.|..|.:||..:....|...|.|.|:
Zfish   888 S----AGRLASRLSSTPHHLQQGMTLAFLENQLSSALMLLSASEYRHWLLIYARFLVNEGYEHRL 948

  Fly   822 RVFLDDLLSMPEPGISQF-------VPKLELMQCVLDTLKPHSEWNRLHSEYTELLK 871
            |....|||.......|..       :.|.:|:..||..:..:..:.||.:||.:.|:
Zfish   949 RELCQDLLGPVHKSSSSSWESTVLGLRKRDLLTEVLPVIGQNLRFQRLFTEYQDQLE 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	225/360 (63%)
		WD40	14..349	CDD:238121	216/337 (64%)
		WD40 repeat	16..68	CDD:293791	34/51 (67%)
		WD40 repeat	74..127	CDD:293791	29/54 (54%)
		WD40 repeat	132..169	CDD:293791	23/36 (64%)
		WD40 repeat	176..211	CDD:293791	18/34 (53%)
		WD40 repeat	223..263	CDD:293791	32/39 (82%)
		WD40 repeat	275..322	CDD:293791	26/47 (55%)
		WD40 repeat	328..350	CDD:293791	9/21 (43%)
		HIRA_B	423..442	CDD:286531	13/18 (72%)
		Hira	629..820	CDD:284895	52/201 (26%)
hira	XP_696478.2	WD40	11..352	CDD:238121	217/340 (64%)
		WD40	<12..382	CDD:225201	230/369 (62%)
		WD40 repeat	16..65	CDD:293791	31/48 (65%)
		WD40 repeat	74..129	CDD:293791	29/54 (54%)
		WD40 repeat	134..171	CDD:293791	23/36 (64%)
		WD40 repeat	178..213	CDD:293791	18/34 (53%)
		WD40 repeat	226..265	CDD:293791	32/38 (84%)
		WD40 repeat	331..354	CDD:293791	9/22 (41%)
		HIRA_B	448..469	CDD:286531	14/20 (70%)
		Hira	756..947	CDD:284895	51/199 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586517
Domainoid	1	1.000	65	1.000	Domainoid score	I10096
eggNOG	1	0.900	-	-		E1_KOG0973
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48172
Inparanoid	1	1.050	625	1.000	Inparanoid score	I840
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	1	1.000	-	-		FOG0003162
OrthoInspector	1	1.000	-	-		oto39791
orthoMCL	1	0.900	-	-		OOG6_103167
Panther	1	1.100	-	-	LDO	PTHR13831
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R561
SonicParanoid	1	1.000	-	-		X3052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790