DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hira and WDR33

DIOPT Version :9

Sequence 1:NP_572401.2 Gene:Hira / 31680 FlyBaseID:FBgn0022786 Length:1047 Species:Drosophila melanogaster
Sequence 2:NP_060853.3 Gene:WDR33 / 55339 HGNCID:25651 Length:1336 Species:Homo sapiens


Alignment Length:547 Identity:113/547 - (20%)
Similarity:181/547 - (33%) Gaps:163/547 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 VNC----VRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVL 133
            |.|    |||:..|:.|.:|:......:|            .|:..|.|:     .|:.||..|.
Human   118 VKCPVFVVRWTPEGRRLVTGASSGEFTLW------------NGLTFNFET-----ILQAHDSPVR 165

  Fly   134 DLAWSPNDVYL-----------------------------------------ASCSIDNTVIIWD 157
            .:.||.||:::                                         |:||.|.||.|||
Human   166 AMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWD 230

  Fly   158 AQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDD--RSIKIWN-TMNWSLSHTITEPFEECGG 219
            .... |....|:||...||.|.|.|....:.|.|.|  :.||.|: ....||:            
Human   231 FLRC-HEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLA------------ 282

  Fly   220 TTH-----ILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCD-KDFVGHRKAVTCVRFHNSI 278
            |.|     ::.:..:.:|.:|::|...:    ..::.:....|.: :.|.||:|..|.|.:|   
Human   283 TLHAHKNTVMEVKLNLNGNWLLTASRDH----LCKLFDIRNLKEELQVFRGHKKEATAVAWH--- 340

  Fly   279 LSRQENDGSPSKPLQYCCLAVGSRDRSLSVWMTALQRP---MVVIHELFNASILDLTWGPQECLL 340
                        |:.....|.|..|.||..|...:::.   |.:.||   ..|..|.|.|.    
Human   341 ------------PVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHE---GMIWSLAWHPL---- 386

  Fly   341 MACSVDGSIACLKFTEEELGKAISEEEQNAIIRKMYGKNYVNGL---GKSAPVLEHPQRLLLPQG 402
                  |.|.| ..:.:...|..:.......:|..|..|.:.|:   |.....||.....::|..
Human   387 ------GHILC-SGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGM 444

  Fly   403 DKPTKFPLSNNNEANQRPISKQ------------TETRTKDGKRRITPMFIPLHEDGPTSLSMNI 455
            ..|.:..|:...|...:..|.:            .|...|| ::::....:|..:..|.......
Human   445 GIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKD-QKKVPQKKVPYAKPIPAQFQQAW 508

  Fly   456 VSSSGSSTTALTSCSAAIGTLPAAAPTESAATPLMPLEPLVSKIDLGRLDSRLKTQ-PASQRRQS 519
            :.:.                :|..||.|....         .|.|: :|:.:.||| ...|...:
Human   509 MQNK----------------VPIPAPNEVLND---------RKEDI-KLEEKKKTQAEIEQEMAT 547

  Fly   520 LPFDPGQSNELLRTPRLEEHQSSTCSP 546
            |.:...|..|.|:..||.:.|.....|
Human   548 LQYTNPQLLEQLKIERLAQKQVEQIQP 574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HiraNP_572401.2 WD40 <12..370 CDD:225201 77/353 (22%)
WD40 14..349 CDD:238121 74/332 (22%)
WD40 repeat 16..68 CDD:293791
WD40 repeat 74..127 CDD:293791 12/56 (21%)
WD40 repeat 132..169 CDD:293791 15/77 (19%)
WD40 repeat 176..211 CDD:293791 12/37 (32%)
WD40 repeat 223..263 CDD:293791 4/40 (10%)
WD40 repeat 275..322 CDD:293791 9/49 (18%)
WD40 repeat 328..350 CDD:293791 5/21 (24%)
HIRA_B 423..442 CDD:286531 3/30 (10%)
Hira 629..820 CDD:284895
WDR33NP_060853.3 WD 1 117..156 12/54 (22%)
WD40 121..>405 CDD:225201 75/346 (22%)
WD40 121..402 CDD:238121 75/343 (22%)
WD40 repeat 122..159 CDD:293791 11/53 (21%)
WD 2 159..198 7/38 (18%)
WD40 repeat 165..200 CDD:293791 4/34 (12%)
WD 3 200..239 10/39 (26%)
WD40 repeat 205..241 CDD:293791 10/36 (28%)
WD 4 242..283 15/52 (29%)
WD40 repeat 248..285 CDD:293791 13/48 (27%)
WD 5 286..325 4/42 (10%)
WD40 repeat 291..328 CDD:293791 4/40 (10%)
WD 6 329..369 13/54 (24%)
WD40 repeat 336..371 CDD:293791 9/49 (18%)
WD 7 373..412 10/52 (19%)
WD40 repeat 378..402 CDD:293791 8/34 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..1336 2/7 (29%)
Med15 594..>989 CDD:255446
Collagen 730..791 CDD:189968
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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