DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and atg16l1

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001017343.1	Gene:	atg16l1 / 550097	XenbaseID:	XB-GENE-1011170	Length:	622	Species:	Xenopus tropicalis

Alignment Length:	238	Identity:	57/238 - (23%)
Similarity:	98/238 - (41%)	Gaps:	41/238 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 YTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFP-HSVATLKGHTGLVKGVSWDPLGRF 186
            |:...|||:|..:.:||....||:..:|..|.:||..... .:..:|.|....:..:.:|..|.:
Frog   331 YSFDAHDGEVNAVRFSPGSRLLATGGMDRRVKLWDVIGNKCEAKGSLTGSNAGITSIEFDSAGSY 395

  Fly   187 LASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVS-AHAMNGGGPTAQI 250
            |.:.|:|.:.:||...::.|.||:|      |.:..:|...:..|...:|| :|     ..|.::
Frog   396 LLAASNDFASRIWTVDDYRLRHTLT------GHSGKVLSAKFLLDNARIVSGSH-----DRTLKL 449

  Fly   251 IEREGWKCDKD-FVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVWMTALQ 314
            .:.....|.|. |.|.    :|    |.|:..::            |:..|..|:.:..|..
Frog   450 WDLRSKVCIKTVFAGS----SC----NDIVCTEQ------------CVMSGHFDKKIRFWDI--- 491

  Fly   315 RPMVVIHEL-FNASILDLTWGPQECLLMACSVDGSIACLKFTE 356
            |...::.|| ....|..|...|:...|::||.|..|   |.|:
Frog   492 RTECIVRELELQGRITALDLNPERTQLLSCSRDDLI---KITD 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	57/238 (24%)
		WD40	14..349	CDD:238121	54/229 (24%)
		WD40 repeat	16..68	CDD:293791
		WD40 repeat	74..127	CDD:293791	1/3 (33%)
		WD40 repeat	132..169	CDD:293791	9/37 (24%)
		WD40 repeat	176..211	CDD:293791	10/34 (29%)
		WD40 repeat	223..263	CDD:293791	8/41 (20%)
		WD40 repeat	275..322	CDD:293791	7/46 (15%)
		WD40 repeat	328..350	CDD:293791	7/21 (33%)
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
atg16l1	NP_001017343.1	ATG16	31..206	CDD:370001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..78
		WIPI2-binding. /evidence=ECO:0000250\|UniProtKB:Q676U5	207..230
		FIP200-binding. /evidence=ECO:0000250\|UniProtKB:Q676U5	230..242
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..320
		WD40	333..620	CDD:238121	56/236 (24%)
		WD 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	335..374		12/38 (32%)
		WD40 repeat	341..379	CDD:293791	9/37 (24%)
		WD 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	379..418		9/38 (24%)
		WD40 repeat	384..420	CDD:293791	10/35 (29%)
		WD 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	421..460		8/43 (19%)
		WD40 repeat	427..462	CDD:293791	8/39 (21%)
		WD 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	462..499		10/59 (17%)
		WD40 repeat	467..500	CDD:293791	8/51 (16%)
		WD 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	501..540		10/34 (29%)
		WD40 repeat	506..542	CDD:293791	10/29 (34%)
		WD 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	547..588
		WD40 repeat	552..576	CDD:293791
		WD 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	590..622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910