DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and tbl1xr1

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001017274.1	Gene:	tbl1xr1 / 550028	XenbaseID:	XB-GENE-482046	Length:	524	Species:	Xenopus tropicalis

Alignment Length:	390	Identity:	95/390 - (24%)
Similarity:	133/390 - (34%)	Gaps:	135/390 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GQGSDCGRVVIWNLLPVLSDKA--------------EFDADVP--KMLCQMDQHLACVNCVRWSQ 80
            |.|....|  |||    ||:.:              |...|||  |.:..:|          |:.
Frog   197 GSGDSTAR--IWN----LSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLD----------WNS 245

  Fly    81 NGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVYLA 145
            .|..||:||.|....||.|....:.                  ||..|.|.:..|.|:....::.
Frog   246 EGTLLATGSYDGFARIWTKDGNLAS------------------TLGQHKGPIFALKWNKKGNFIL 292

  Fly   146 SCSIDNTVIIWDA------QAFP-HS---------------------------------VATLKG 170
            |..:|.|.|||||      |.|| ||                                 :.|.:|
Frog   293 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQG 357

  Fly   171 HTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYL 235
            ||..|..:.|||.|..|||.|||.::|||:..:.:..|.:....:|      |..:.|||.|.
Frog   358 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKHDTCVHDLQAHNKE------IYTIKWSPTGP-- 414

  Fly   236 VSAHAMNGGGPTAQIIEREG--------WKCDK-----DFVGHRKAVTCVRFHNSILSRQENDGS 287
                  ....|.|.::....        |..|:     ....|::.|..|.|        ..||
Frog   415 ------GTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAF--------SPDG- 464

  Fly   288 PSKPLQYCCLAVGSRDRSLSVWMTALQRPMVVIHELFNASILDLTWGPQECLLMACSVDGSIACL 352
                 :|  ||.||.|:.:.:|.|  |...:|........|.::.|......:.|.:.|||:..|
Frog   465 -----RY--LASGSFDKCVHIWNT--QTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVL 520

Fly 353 352
Frog 521 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	95/390 (24%)
		WD40	14..349	CDD:238121	93/385 (24%)
		WD40 repeat	16..68	CDD:293791	13/51 (25%)
		WD40 repeat	74..127	CDD:293791	12/52 (23%)
		WD40 repeat	132..169	CDD:293791	16/76 (21%)
		WD40 repeat	176..211	CDD:293791	14/34 (41%)
		WD40 repeat	223..263	CDD:293791	9/52 (17%)
		WD40 repeat	275..322	CDD:293791	12/46 (26%)
		WD40 repeat	328..350	CDD:293791	6/21 (29%)
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
tbl1xr1	NP_001017274.1	LisH	7..31	CDD:369916
		WD40	174..480	CDD:238121	84/346 (24%)
		WD40 repeat	182..225	CDD:293791	8/33 (24%)
		WD40 repeat	239..274	CDD:293791	13/62 (21%)
		WD40 repeat	279..315	CDD:293791	11/35 (31%)
		WD40 repeat	322..356	CDD:293791	1/33 (3%)
		WD40 repeat	362..398	CDD:293791	15/35 (43%)
		WD40 repeat	404..449	CDD:293791	9/52 (17%)
		WD40 repeat	455..479	CDD:293791	11/39 (28%)
		WD40 repeat	496..522	CDD:293791	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910