DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and fzr

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster

Alignment Length:	287	Identity:	73/287 - (25%)
Similarity:	108/287 - (37%)	Gaps:	74/287 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIWR 98
            |:..|.|.:|            |....|.:.:::.|.|.|..:.|  |...|:|||.|:.| |.|
  Fly   232 GTHHGYVTVW------------DVAANKQINKLNGHSARVGALAW--NSDILSSGSRDRWI-IQR 281

  Fly    99 KSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPH 163
            .:.       |..:|....       |.||..:|..|.|||::.||||...||.:.:|:    .|
  Fly   282 DTR-------TPQLQSERR-------LAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWN----QH 328

  Fly   164 SVATLKG---HTGLVKGVSWDPLGRFLASQ---SDDRSIKIWNTMNWSLSHTITEPFEECGGTTH 222
            ||..::.   |...||.::|.|....|.:.   :.||.|:.|||:.       .:|.:.....:.
  Fly   329 SVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLT-------GQPMQCVDTGSQ 386

  Fly   223 ILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDK-----DFVGHRKAVTCVRFHNSILSRQ 282
            :..|:||.....|||.|    |....||:.   ||...     ...||...|..:..
  Fly   387 VCNLAWSKHSSELVSTH----GYSQNQILV---WKYPSLTQVAKLTGHSYRVLYLAL-------- 436

  Fly   283 ENDGSPSKPLQYCCLAVGSRDRSLSVW 309
            ..||.        .:..|:.|.:|..|
  Fly   437 SPDGE--------AIVTGAGDETLRFW 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	73/287 (25%)
		WD40	14..349	CDD:238121	73/287 (25%)
		WD40 repeat	16..68	CDD:293791	6/33 (18%)
		WD40 repeat	74..127	CDD:293791	13/52 (25%)
		WD40 repeat	132..169	CDD:293791	15/36 (42%)
		WD40 repeat	176..211	CDD:293791	10/37 (27%)
		WD40 repeat	223..263	CDD:293791	12/44 (27%)
		WD40 repeat	275..322	CDD:293791	6/35 (17%)
		WD40 repeat	328..350	CDD:293791
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
fzr	NP_524852.2	WD40	<174..469	CDD:225201	73/287 (25%)
		WD40	178..456	CDD:238121	73/287 (25%)
		WD40 repeat	217..254	CDD:293791	6/33 (18%)
		WD40 repeat	260..296	CDD:293791	13/52 (25%)
		WD40 repeat	301..337	CDD:293791	15/39 (38%)
		WD40 repeat	344..382	CDD:293791	11/44 (25%)
		WD40 repeat	387..425	CDD:293791	12/44 (27%)
		WD40 repeat	431..457	CDD:293791	7/41 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910