DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and CG42233

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster

Alignment Length:	1002	Identity:	183/1002 - (18%)
Similarity:	321/1002 - (32%)	Gaps:	388/1002 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 HLACVNCVRWSQNGQNLASGSDDKLIMIW---RKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDG 130
            |..|||.:.:|..||.||||.|||.:::|   |:.....|  ....|.:.|.|
  Fly    95 HYGCVNALEFSSGGQFLASGGDDKRVLLWNIDRELVSKLG--KPRSMNEKHAS------------ 145

  Fly   131 DVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLK-----GHTGLVKGVSWDPL-GRFLAS 189
            ::..|.:...:.|:.|...|:.||       .|.:.|.|     .|.|.|.|:|.|.: |..|:.
  Fly   146 NIFCLGFDTQNSYIFSGGNDDLVI-------QHDLETGKILNHFSHDGPVYGLSVDRISGHLLSV 203

  Fly   190 QSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSP-DGQYLVSAHAMNGGGPTAQIIER 253
            .::...|.:::     |....:||.......|....:.:.| :|.:|.:|:|..|    |.:
  Fly   204 ATEHGEILVYD-----LRAGKSEPLAIAKFKTPFNAVEFHPLNGNFLATANAKRG----AML--- 256

  Fly   254 EGWK--------CDKDFVGHRKAVTCVRFH-NSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVW 309
              |.        |..:::....:...|||: |..|....:...|  |:.|   :.|:.:
  Fly   257 --WDLRHHQQALCQYNYIPESPSCMSVRFNCNGTLLLTLHRRLP--PILY---SPGAPE------ 308

  Fly   310 MTALQRPMVVIH--ELFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEEQ-NAI 371
                  |:...:  |.||:           |.:.:|:..|       .::||  .:|..:. |..
  Fly   309 ------PVATFYHDEYFNS-----------CTMKSCTFAG-------PQDEL--VVSGSDNFNMF 347

  Fly   372 IRKMYGKNY--VNGLGKSAPVLEHPQR-------------LLLPQG-DKPTKF--PLSNN----- 413
            |.::.|.:.  .|...::.||:....|             ||...| :|..|.  |.:..
  Fly   348 IWRLEGVDLDEKNQWMETTPVILAGHRSIVNQVRYNRERCLLASSGVEKIIKLWSPFAQQGWEGS 412

  Fly   414 -NEANQRP-------------ISKQTETRTKDGKRRITPMFIPLHEDGPTSLSMNIVSSSGSSTT 464
             .:|...|             :|:....|:.|..:.:...|..|.:....|.|.....:|..|:|
  Fly   413 LTQAEALPYCTRALYRESSDHVSQDFSARSTDEDQVMLAFFDTLVQHELESWSTVDNQNSSKSST 477

  Fly   465 ALTSCSAAIGTLPAAAPTESAATPLMPLEPLVSKIDLGRLDSRLKTQPASQRRQSLPFDPGQSNE 529
            ..::||      .|::|||                           :|:.:..|....|..|:.|
  Fly   478 HTSTCS------EASSPTE---------------------------EPSDEEDQDPQTDRNQNEE 509

  Fly   530 LLRTPRLEEHQSSTCSPSNLNVTATGKSEFVKAALDYRLHVSNGHLKTQHGMLAKVTASDSKEML 594
            .::...::       :|   ||:                                       |:.
  Fly   510 NVQDQDID-------TP---NVS---------------------------------------ELS 525

  Fly   595 WEFYVGSPLVNLNLCEKYAMLCSLDGSMRLISMETGCPVFPAISLTSSAVHCAFSPDNSLVGVLT 659
            |:.|..                      |:..:
  Fly   526 WQTYPN----------------------RIFYL-------------------------------- 536

  Fly   660 ECGLLRIWDIAKKVVSLAAGCLELLNKHGTAAQFSVTNQGMPLIGFPSGNSYSYSTSLQSWLVLA 724
                     ||||..||    |:|
  Fly   537 ---------IAKKRRSL----LQL----------------------------------------- 547

  Fly   725 TKDAIMYHGIRGTL--PRDMDQMQQKFPLLSMQASSQNYFSFTGSMELRHSESWQQCAKIRFIEN 787
                    .:|||.  ||::||:.|:......||::|...|           .|.:..:..|.::
  Fly   548 --------AVRGTSRHPRNVDQLLQRLIGEQKQAATQARIS-----------DWLEETQRLFGDD 593

  Fly   788 QIKLCEALQSLDELQHWHKMLTFQLATHGSEKRMRVFLDDLLSMPEPGISQFVPKLELMQCVLDT 852
            ::....|..:..|.:....:|..:      .:|.:.|  .::..|:..|:|...|.:|.| ::.|
  Fly   594 ELPTTSAEAAAREQRRRDGVLLCR------NRRTQEF--KIVETPKSRITQRTRKRKLRQ-LIQT 649

  Fly   853 LKPHSEWNRLHSEYTELLKECKSERQKDIFATPAPPQQKTASSAGSSPRSGEATGEEV-TEKDGA 916
            .|......|..:  ||:   .:.....|..|:....:::|:|...::..|.|.  |.| |:.||
  Fly   650 TKHRRATGRPRT--TEM---DEGSASSDTGASYDSDEEETSSGDNNNNNSNER--ESVRTDDDG- 706

  Fly   917 TAVAAAVVAGSRMAVTTGTSTTTTTTASSSLSSSGSSSST---SGSGSSSSSSSTSSLSVPQPAP 978
                            ..:|||:.|:..:..|.:.|:||:   ....|:::|..||:    |...
  Fly   707 ----------------DNSSTTSLTSMEAQFSQAPSTSSSFLFHQLESNNNSQHTSN----QNHK 751

  Fly   979 SLSPEIQTLDSPTVCIDDEILSASSSL 1005
            :|:..|     |..|..:...|.|||:
  Fly   752 ALNGLI-----PDNCNTESTASTSSSM 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	70/322 (22%)
		WD40	14..349	CDD:238121	67/300 (22%)
		WD40 repeat	16..68	CDD:293791
		WD40 repeat	74..127	CDD:293791	17/55 (31%)
		WD40 repeat	132..169	CDD:293791	8/36 (22%)
		WD40 repeat	176..211	CDD:293791	7/35 (20%)
		WD40 repeat	223..263	CDD:293791	9/48 (19%)
		WD40 repeat	275..322	CDD:293791	7/49 (14%)
		WD40 repeat	328..350	CDD:293791	3/21 (14%)
		HIRA_B	423..442	CDD:286531	3/18 (17%)
		Hira	629..820	CDD:284895	25/192 (13%)
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	82/380 (22%)
		WD40 repeat	56..91	CDD:293791
		WD40	90..402	CDD:295369	82/378 (22%)
		WD40 repeat	100..142	CDD:293791	15/43 (35%)
		WD40 repeat	147..183	CDD:293791	9/42 (21%)
		WD40 repeat	191..225	CDD:293791	8/38 (21%)
		WD40 repeat	232..270	CDD:293791	9/46 (20%)
		WD40 repeat	278..371	CDD:293791	25/129 (19%)
		WD40 repeat	377..401	CDD:293791	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910