DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and tex

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_649784.1	Gene:	tex / 40983	FlyBaseID:	FBgn0037569	Length:	320	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	79/338 - (23%)
Similarity:	127/338 - (37%)	Gaps:	94/338 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 HLACVNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVL 133
            |::.|:.|.|:.:|:.|||||.||.::::......   |..|.            |.|||...|.
  Fly    27 HMSKVHSVCWNADGRYLASGSFDKTVVVYSLERDR---FLKGN------------TYRGHTASVD 76

  Fly   134 DLAW-SPNDVYLASCSIDNTVIIWDAQAFP-HSVATLKGHTGLVKGVSWDPLGRFLASQS----- 191
            .|.| ..|....|:.|.|.||.|||.:... .||...||..   ..::|.|.|:.:|..:
  Fly    77 QLCWHRTNPDQFATASGDKTVRIWDIRVGKCVSVTNTKGEN---INIAWSPDGKTIAVGNKEDLI 138

  Fly   192 ---DDRSIKI--------------WNTMN--------WSLSHTITEPFEECGGT-----THILRL 226
               |.|:.||              ||..|        ....|.::.|..|...|     .:.:.:
  Fly   139 TFIDTRTNKIRVEEPFSFEVNEISWNNTNDLFFLTNGLGCMHILSYPSLEHQMTLKAHPANCICI 203

  Fly   227 SWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKP 291
            .:.|.|:|..:      |...||:   ..|..::        :.|:|    ::||.|   .|.:.
  Fly   204 EFGPTGKYFAT------GSADAQV---SLWDANE--------LACLR----MISRLE---WPVRT 244

  Fly   292 LQYC----CLAVGSRDRSLSVWMTALQRPMVVIHELFNASILDLTWGPQECLL-MACSVD----- 346
            :.:.    .:|:.|.|..:.:..|.....:..||  .:||...:.|.|::.|| .||...
  Fly   245 ISFSHDERMIALASEDLIIDIAFTETGERVTDIH--VDASTFTVAWHPKQYLLAYACDEKDNDRR 307

  Fly   347 ---GSIACLKFTE 356
               |::....|:|
  Fly   308 RDAGNVKIYGFSE 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	79/338 (23%)
		WD40	14..349	CDD:238121	77/329 (23%)
		WD40 repeat	16..68	CDD:293791
		WD40 repeat	74..127	CDD:293791	13/52 (25%)
		WD40 repeat	132..169	CDD:293791	14/38 (37%)
		WD40 repeat	176..211	CDD:293791	12/64 (19%)
		WD40 repeat	223..263	CDD:293791	7/39 (18%)
		WD40 repeat	275..322	CDD:293791	9/50 (18%)
		WD40 repeat	328..350	CDD:293791	7/30 (23%)
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
tex	NP_649784.1	WD40	19..263	CDD:421866	65/277 (23%)
		WD40 repeat	32..70	CDD:293791	13/52 (25%)
		WD40 repeat	75..112	CDD:293791	14/36 (39%)
		WD40 repeat	118..183	CDD:293791	12/64 (19%)
		WD40 repeat	200..234	CDD:293791	9/54 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910