DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and poc1b

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_956412.1	Gene:	poc1b / 386932	ZFINID:	ZDB-GENE-031118-54	Length:	490	Species:	Danio rerio

Alignment Length:	549	Identity:	118/549 - (21%)
Similarity:	203/549 - (36%)	Gaps:	142/549 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 HLACVNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVL 133
            |...::|..::.|.:.||:||.||.:|||..:..:..                 :...||...:.
Zfish    17 HKDVISCADFNPNNKQLATGSCDKSLMIWNLAPKARA-----------------FRFVGHTDVIT 64

  Fly   134 DLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKI 198
            .:.::|:...:||.|.|.||.:|.......| ...|.||..|:.|::...|:.|.:.|||:|:|:
Zfish    65 GVNFAPSGSLVASSSRDQTVRLWTPSIKGES-TVFKAHTASVRSVNFSRDGQRLVTASDDKSVKV 128

  Fly   199 WNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDKDFV 263
            |........:::..      .|..:....:||||:.:.|.    |...|.::.:....:|...|.
Zfish   129 WGVERKKFLYSLNR------HTNWVRCARFSPDGRLIASC----GDDRTVRLWDTSSHQCTNIFT 183

  Fly   264 GHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVWMTALQRPMVVIHELFNASI 328
            .:..:.|.|.|::|        |:        |:|....|.::.:|.....: ::..:::.||.:
Zfish   184 DYGGSATFVDFNSS--------GT--------CIASSGADNTIKIWDIRTNK-LIQHYKVHNAGV 231

  Fly   329 LDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEEQNAIIRKMYGKNYVNGLGKSAPVL-- 391
            ...::.|....|::.|.|.:|..|...|..|               :|..:     |...|||
Zfish   232 NCFSFHPSGNYLISGSSDSTIKILDLLEGRL---------------IYTLH-----GHKGPVLTV 276

  Fly   392 --EHPQRLLLPQG-DKPTKFPLSNNNEANQRPISKQTETRTKDGKRRITPMFIPLHEDGPTSLSM 453
              .....|....| |.......:|.:..|.|.:..:       ..:|:||       |.|..| |
Zfish   277 TFSRDGDLFASGGADSQVLMWKTNFDSLNYRELLSR-------HSKRVTP-------DPPPHL-M 326

  Fly   454 NIVSSS------GSSTTALTSCSAAIGTLPAAAPTESAATPLMPLEPLVSKIDLGRL-----DSR 507
            :|...|      .:.|..:.          ..|.|:|.       :|.|  :::||:     |:|
Zfish   327 DIYPRSHHRHHPQNGTVEIN----------PVADTQST-------DPQV--VEVGRVVFSTTDAR 372

  Fly   508 LKTQPASQRRQSLPFDPGQSNELLRT---PRLEEHQSS--------TCSP---SNLNVTATGKSE 558
            .....:|.|.|   |..|.....|||   .|.||.::.        |.||   |.:..:.|...|
Zfish   373 NYDGASSSRAQ---FTSGMDLGPLRTHTQAREEEDENQEERFAGGMTASPAERSGIPSSLTSTLE 434

  Fly   559 FV----------KAALDYRLHVSNGHLKT 577
            .:          .|.|:.||.::...|:|
Zfish   435 NIVQQLDILTQTVAVLEERLTLTEDKLRT 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	65/300 (22%)
		WD40	14..349	CDD:238121	61/279 (22%)
		WD40 repeat	16..68	CDD:293791
		WD40 repeat	74..127	CDD:293791	11/52 (21%)
		WD40 repeat	132..169	CDD:293791	9/36 (25%)
		WD40 repeat	176..211	CDD:293791	9/34 (26%)
		WD40 repeat	223..263	CDD:293791	8/39 (21%)
		WD40 repeat	275..322	CDD:293791	6/46 (13%)
		WD40 repeat	328..350	CDD:293791	4/21 (19%)
		HIRA_B	423..442	CDD:286531	3/18 (17%)
		Hira	629..820	CDD:284895
poc1b	NP_956412.1	WD40	10..298	CDD:238121	73/345 (21%)
		WD40	14..>300	CDD:225201	73/347 (21%)
		WD 1. /evidence=ECO:0000255	16..55		12/54 (22%)
		WD40 repeat	22..58	CDD:293791	11/52 (21%)
		WD 2. /evidence=ECO:0000255	58..97		11/39 (28%)
		WD40 repeat	63..99	CDD:293791	9/36 (25%)
		WD 3. /evidence=ECO:0000255	100..139		12/38 (32%)
		WD40 repeat	106..141	CDD:293791	9/34 (26%)
		WD 4. /evidence=ECO:0000255	142..181		9/48 (19%)
		WD40 repeat	147..181	CDD:293791	8/37 (22%)
		WD 5. /evidence=ECO:0000255	184..223		9/55 (16%)
		WD40 repeat	189..225	CDD:293791	9/52 (17%)
		WD 6. /evidence=ECO:0000255	226..265		10/53 (19%)
		WD40 repeat	231..254	CDD:293791	5/22 (23%)
		WD 7. /evidence=ECO:0000255	268..307		9/38 (24%)
		WD40 repeat	273..314	CDD:293791	8/47 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..427		15/54 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910