DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and Tbl1xr1

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001102411.1	Gene:	Tbl1xr1 / 365755	RGDID:	1560053	Length:	514	Species:	Rattus norvegicus

Alignment Length:	390	Identity:	95/390 - (24%)
Similarity:	132/390 - (33%)	Gaps:	135/390 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GQGSDCGRVVIWNLLPVLSDKA--------------EFDADVP--KMLCQMDQHLACVNCVRWSQ 80
            |.|....|  |||    ||:.:              |...|||  |.:..:|          |:.
  Rat   187 GSGDSTAR--IWN----LSENSTSGPTQLVLRHCIREGGQDVPSNKDVTSLD----------WNS 235

  Fly    81 NGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVYLA 145
            .|..||:||.|....||.|....:.                  ||..|.|.:..|.|:....::.
  Rat   236 EGTLLATGSYDGFARIWTKDGNLAS------------------TLGQHKGPIFALKWNKKGNFIL 282

  Fly   146 SCSIDNTVIIWDA------QAFP-HS---------------------------------VATLKG 170
            |..:|.|.|||||      |.|| ||                                 :.|.:|
  Rat   283 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQG 347

  Fly   171 HTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYL 235
            ||..|..:.|||.|..|||.|||.::|||:....:..|.:....:|      |..:.|||.|.
  Rat   348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKE------IYTIKWSPTGP-- 404

  Fly   236 VSAHAMNGGGPTAQIIEREG--------WKCDK-----DFVGHRKAVTCVRFHNSILSRQENDGS 287
                  ....|.|.::....        |..|:     ....|::.|..|.|        ..||
  Rat   405 ------GTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAF--------SPDG- 454

  Fly   288 PSKPLQYCCLAVGSRDRSLSVWMTALQRPMVVIHELFNASILDLTWGPQECLLMACSVDGSIACL 352
                 :|  ||.||.|:.:.:|.|  |...:|........|.::.|......:.|.:.|||:..|
  Rat   455 -----RY--LASGSFDKCVHIWNT--QTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVL 510

Fly 353 352
Rat 511 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	95/390 (24%)
		WD40	14..349	CDD:238121	93/385 (24%)
		WD40 repeat	16..68	CDD:293791	13/51 (25%)
		WD40 repeat	74..127	CDD:293791	12/52 (23%)
		WD40 repeat	132..169	CDD:293791	16/76 (21%)
		WD40 repeat	176..211	CDD:293791	14/34 (41%)
		WD40 repeat	223..263	CDD:293791	9/52 (17%)
		WD40 repeat	275..322	CDD:293791	12/46 (26%)
		WD40 repeat	328..350	CDD:293791	6/21 (29%)
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
Tbl1xr1	NP_001102411.1	LisH	7..31	CDD:369916
		WD40	164..470	CDD:238121	84/346 (24%)
		WD40 repeat	172..215	CDD:293791	8/33 (24%)
		WD40 repeat	228..264	CDD:293791	13/63 (21%)
		WD40 repeat	270..306	CDD:293791	12/35 (34%)
		WD40 repeat	311..346	CDD:293791	1/34 (3%)
		WD40 repeat	353..388	CDD:293791	14/34 (41%)
		WD40 repeat	394..439	CDD:293791	9/52 (17%)
		WD40 repeat	445..483	CDD:293791	15/55 (27%)
		WD40 repeat	486..509	CDD:293791	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910