DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and Hira

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_038944477.1	Gene:	Hira / 363849	RGDID:	1584950	Length:	1048	Species:	Rattus norvegicus

Alignment Length:	1031	Identity:	380/1031 - (36%)
Similarity:	537/1031 - (52%)	Gaps:	197/1031 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KQIFSVDIHKDCTKFATGGQGSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQMDQHLACVNCVRW 78
            |.|||||||.|.|||||||||.|.|:|||||:.|||.:..|.|.::||||||||.||||||||||
  Rat    35 KPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRW 99

  Fly    79 SQNGQNLASGSDDKLIMIWRKSA--GSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPND 141
            |.:|..||||.||||||:|:::.  |.|.|||:.|...|.|.|:|...||.|.|||:|:||||:|
  Rat   100 SNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRSHSGDVMDVAWSPHD 164

  Fly   142 VYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSL 206
            .:|||||:||||:||:|..||..:|||:||:|||||::|||:|:::|||:||||:|:|.|::|.|
  Rat   165 AWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQL 229

  Fly   207 SHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDKDFVGHRKAVTC 271
            ..:||:||:|||||||:|||||||||.|||||||||..|||||||||||||.:.||||||||||.
  Rat   230 ETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTV 294

  Fly   272 VRFHNSILSRQENDGSPSKP-LQYCCLAVGSRDRSLSVWMTALQRPMVVIHELFNASILDLTWGP 335
            |:|:..|..:::.:||.:|| ..|||.||||:|||||||:|.|:||:|||||||:.||:|::|..
  Rat   295 VKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTL 359

  Fly   336 QECLLMACSVDGSIACLKFTEEELGKAISEEEQNAIIRKMYGKN--YVNGLGKSAPVLEHPQRLL 398
            ....::.||:|||:|.|.|:::|||..:||||::.|.:..|||:  .:.....|..|:|:|:.|.
  Rat   360 NGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLK 424

  Fly   399 LPQGDKPTKFPLSN----------------NNEA----NQRPISKQTETRTKDGKRRITPMFIPL 443
            ..:..:..:....|                |.|:    .:..:.||.||||.||:|||||:.|..
  Rat   425 YQRRQQQQQLDQKNATTRETSSASSVTGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQ 489

  Fly   444 HEDG------------------------PTSLSMNIVSS-SGSSTTALTSCSAAIG-----TLPA 478
            .:.|                        .:||:..::|| ||.....|.|.:.:.|     |.|.
  Rat   490 LDTGAGDRTQGLALPRDFSTAFFNSIPLSSSLAGTMLSSPSGQQLLPLDSSTPSFGASKPCTEPV 554

  Fly   479 AA----PT---------ESAATPLMPLEPLV----SKID-LGRLDSRLKTQPASQRRQSLPFDPG 525
            ||    ||         .:.:|| ..|.|.|    |||: :...|||.     ::|.::.|..|.
  Rat   555 AATSARPTGEPVSKDSMNATSTP-AALSPSVLTTPSKIEPMKAFDSRF-----TERSKATPGAPS 613

  Fly   526 ------------QSNELLRTPRLEEHQSSTCS--------------------------------- 545
                        :...|:|..|..|..||:.|
  Rat   614 LTSVIPTAVERLKEQNLVRELRSRELDSSSDSDEKVHLAKPSSLSKRKLELEVETVEKKKKGRPR 678

  Fly   546 ------PSNLNVTATGKSEFVKAAL------------------DYRLHVSN---------GHLKT 577
                  |.:|:|.:.......|.|:                  .:.|.||:         ..:.|
  Rat   679 KDSRLLPVSLSVQSPAALSAEKEAMCLSAPALALKLPIPGPQRAFTLQVSSDPSMYIEVENEVTT 743

  Fly   578 QHGM-LAKVTAS-DSKEMLWEFYVGS-PLVNLNLCEKYAMLCSLDGSMRLISMETGC--PVFPAI 637
            ..|: |:::..: :.||  ||..:.| .|.....|:...:.|    ..|::|:.:.|  .:.|.|
  Rat   744 VGGIRLSRLKCNREGKE--WETVLSSRVLTAAGSCDVVCVAC----EKRMLSVFSTCGRRLLPPI 802

  Fly   638 SLTS--SAVHCAFSPDNSLVGVLTECGLLRIWDIAKKVVSLAAGCLE--LLNKHGTAAQFSVTNQ 698
            .|.|  |.:||.    ...|..||....|.:||:.::||.:....|.  |.....|.:|..:|..
  Rat   803 LLPSPISTLHCT----GPYVMALTAAATLSVWDVHRQVVVVKEESLHSILSGSDMTVSQILLTQH 863

  Fly   699 GMPLIGFPSGNSYSYSTSLQSWLVLATKDAIMYH--GIRGTLPRDMDQMQQKFPLLSMQASSQNY 761
            |:|::....|.:|.::.||.:|.:::.|...:..  ..|.:|| ..|.|....||..:|..:.|
  Rat   864 GIPVMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRNSLP-SQDAMLCSGPLAIIQGRTSN- 926

  Fly   762 FSFTGSMELR-----HSESWQQCAKIRFIENQIKLCEALQSLDELQHWHKMLTFQLATHGSEKRM 821
               :|....|     |..  ||.:.:.::|:|:.....|||..|.:||..:....|...|.|.|:
  Rat   927 ---SGRQAARLFSVPHVV--QQESTLAYLESQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRL 986

  Fly   822 RVFLDDLLSMPEPGI-SQF------VPKLELMQCVLDTLKPHSEWNRLHSEYTELL 870
            |....|||....... ||:      :.|.||::.:|..:..:..:.||.:|..|.|
  Rat   987 REICQDLLGPVHCSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQL 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	226/358 (63%)
		WD40	14..349	CDD:238121	215/337 (64%)
		WD40 repeat	16..68	CDD:293791	36/51 (71%)
		WD40 repeat	74..127	CDD:293791	29/54 (54%)
		WD40 repeat	132..169	CDD:293791	23/36 (64%)
		WD40 repeat	176..211	CDD:293791	18/34 (53%)
		WD40 repeat	223..263	CDD:293791	32/39 (82%)
		WD40 repeat	275..322	CDD:293791	26/47 (55%)
		WD40 repeat	328..350	CDD:293791	8/21 (38%)
		HIRA_B	423..442	CDD:286531	13/18 (72%)
		Hira	629..820	CDD:284895	54/203 (27%)
Hira	XP_038944477.1	WD40	35..373	CDD:238121	217/340 (64%)
		WD40 repeat	37..82	CDD:293791	29/44 (66%)
		WD40 repeat	95..150	CDD:293791	30/56 (54%)
		WD40 repeat	155..192	CDD:293791	23/36 (64%)
		WD40 repeat	199..234	CDD:293791	18/34 (53%)
		WD40 repeat	247..286	CDD:293791	32/38 (84%)
		WD40 repeat	294..345	CDD:293791	29/51 (57%)
		WD40 repeat	352..375	CDD:293791	8/22 (36%)
		HIRA_B	469..491	CDD:401417	8/22 (36%)
		Hira	795..985	CDD:400109	29/104 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345451
Domainoid	1	1.000	67	1.000	Domainoid score	I9580
eggNOG	1	0.900	-	-		E1_KOG0973
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48172
Inparanoid	1	1.050	624	1.000	Inparanoid score	I829
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	1	1.000	-	-		FOG0003162
OrthoInspector	1	1.000	-	-		otm44544
orthoMCL	1	0.900	-	-		OOG6_103167
Panther	1	1.100	-	-	LDO	PTHR13831
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800