DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and Tbl1x

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001100434.1	Gene:	Tbl1x / 302711	RGDID:	1563868	Length:	527	Species:	Rattus norvegicus

Alignment Length:	382	Identity:	98/382 - (25%)
Similarity:	135/382 - (35%)	Gaps:	119/382 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GQGSDCGRVVIWNL----------LPVLSDKAEFDADVP--KMLCQMDQHLACVNCVRWSQNGQN 84
            |.|....|  ||||          |.:.....|...|||  |.:..:|          |:.:|..
  Rat   200 GSGDSTAR--IWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLD----------WNSDGTL 252

  Fly    85 LASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSI 149
            ||:||.|....||.:....:.                  ||..|.|.:..|.|:....|:.|..:
  Rat   253 LATGSYDGFARIWTEDGNLAS------------------TLGQHKGPIFALKWNKKGNYILSAGV 299

  Fly   150 DNTVIIWDA------QAFP-HS---------------------------------VATLKGHTGL 174
            |.|.|||||      |.|| ||                                 |.|.:|||..
  Rat   300 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNE 364

  Fly   175 VKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQ------ 233
            |..:.|||.|..|||.|||.::|||:....:..|.:....:|      |..:.|||.|.
  Rat   365 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKE------IYTIKWSPTGPATSNPN 423

  Fly   234 ---YLVSAHAMNGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYC 295
               .|.||    ....|.::.:.|...|......|::.|..|.|        ..||      :|
  Rat   424 SNIMLASA----SFDSTVRLWDVERGVCIHTLTKHQEPVYSVAF--------SPDG------KY- 469

  Fly   296 CLAVGSRDRSLSVWMTALQRPMVVIHELFNASILDLTWGPQECLLMACSVDGSIACL 352
             ||.||.|:.:.:|.|  |...:|........|.::.|..:...:.|.:.|||:..|
  Rat   470 -LASGSFDKCVHIWNT--QSGSLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	98/382 (26%)
		WD40	14..349	CDD:238121	96/377 (25%)
		WD40 repeat	16..68	CDD:293791	13/47 (28%)
		WD40 repeat	74..127	CDD:293791	11/52 (21%)
		WD40 repeat	132..169	CDD:293791	18/76 (24%)
		WD40 repeat	176..211	CDD:293791	14/34 (41%)
		WD40 repeat	223..263	CDD:293791	11/48 (23%)
		WD40 repeat	275..322	CDD:293791	12/46 (26%)
		WD40 repeat	328..350	CDD:293791	6/21 (29%)
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
Tbl1x	NP_001100434.1	LisH	7..31	CDD:369916
		WD40	177..483	CDD:238121	87/338 (26%)
		WD40 repeat	185..232	CDD:293791	9/33 (27%)
		WD40 repeat	242..277	CDD:293791	12/62 (19%)
		WD40 repeat	282..318	CDD:293791	12/35 (34%)
		WD40 repeat	325..359	CDD:293791	2/33 (6%)
		WD40 repeat	365..401	CDD:293791	15/35 (43%)
		WD40 repeat	407..452	CDD:293791	11/48 (23%)
		WD40 repeat	458..482	CDD:293791	11/39 (28%)
		WD40 repeat	499..525	CDD:293791	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910