DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and Chaf1b

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001019912.1	Gene:	Chaf1b / 288242	RGDID:	1307634	Length:	572	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	153/626 - (24%)
Similarity:	244/626 - (38%)	Gaps:	138/626 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AWVHHDDKQIFSVDIHKDCT----KFATGGQGSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQMD 67
            ||  |:.:.::|:|......    :.|:.|..:   .|.||.:     :|......:.:.|..:.
  Rat     9 AW--HNKEPVYSLDFQHAAACRIQRLASAGVDT---AVRIWKV-----EKGPDGKAIVEFLSNLA 63

  Fly    68 QHLACVNCVRWSQNGQNLASGSDDKLIMIWR----KSAGSSGVFGTGGMQKNHESWKCFYTLRGH 128
            :|...||.||:|..|:.||||.||.:|::|:    |.............|.|.|:|....|||||
  Rat    64 RHTKAVNVVRFSPTGEILASGGDDAVILLWKMNDSKEPEQIAFQDEDEAQLNKENWTVVKTLRGH 128

  Fly   129 DGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDD 193
            ..||.|:.|:.:...:||.|:||||||||... ...::....|...|:||:|||||:::|:.|.|
  Rat   129 LEDVYDICWATDGNMMASASVDNTVIIWDVSK-GQKISIFNEHKSYVQGVTWDPLGQYIATLSCD 192

  Fly   194 RSIKIWNTMNWSLSHTITE---------------PFEECGGTTHILRLSWSPDGQYLVS-AHAMN 242
            |.:::::|....::..:::               .|.:....:...|||::|||..|:: |..|.
  Rat   193 RVLRVYSTQKKRVAFNVSKMLSGQGPEGEARSFRMFHDDSMKSFFRRLSFTPDGSLLLTPAGCME 257

  Fly   243 GG---GPTAQIIEREGWKCDKDFVGH-------RKAVTCVRFHNSILSRQENDGSPSKP------ 291
            .|   ..|..:..||..|..   :.|       ..||.|...:..:....|.:.:..:|
  Rat   258 SGENVTNTTYVFSREHLKRP---IAHLPCPGKATLAVRCCPVYFELRPVAETEKASEEPSPELVS 319

  Fly   292 LQY-CCLAVGSRDRSLSVWMTALQRPMVVIHELFNASILDLTWGPQECLLMACSVDGSIACLKFT 355
            |.| ...||.|.| |:.::.|....|...:..:...::.|::|......|...|.||..:.:.|.
  Rat   320 LPYRMVFAVASED-SVLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAVSSTDGYCSFVTFE 383

  Fly   356 EEELGKAISEEEQNAIIRKMYGKNYVNGLGKSAPVLEHPQRLLLPQGDKPTKFPLSNNNEANQRP 420
            :.|||..:.|:                      |||    .:..|...|.||         ||.|
  Rat   384 KGELGVPLKEK----------------------PVL----GVRTPDTAKKTK---------NQNP 413

  Fly   421 ISKQTETRTKDG--KRRITPMFIPLHEDGPTSLSMNIVSSSGSSTTALTSCSAAI--GTLPAAAP 481
            ......:|:.:|  ..||.....|.....||:.|        .:..|:....:||  |..|...|
  Rat   414 QGSSPGSRSAEGTPSNRIQDPSSPCTTPSPTTQS--------PAPPAIKDSPSAIPAGKSPLPRP 470

  Fly   482 TESAATPLMPL-----EPLVSKIDLGRLDSRLKTQP-------------------------ASQR 516
            :|...  |.|.     .|...::.|..|.|..||.|                         ..:.
  Rat   471 SEEKT--LQPAAQNMKAPQPRRVTLNTLQSWGKTAPRRINLTPLRADTAPNPLPSSGAAPSTEEV 533

  Fly   517 RQSLPFDPGQSNELLRTPRLEEHQSSTCSPSNLNVTATGKS 557
            :..:|.:|......|:.|:|||.:..|   .:|:...|.||
  Rat   534 QPEVPGEPQDEPPELKRPKLEEQEGDT---QSLSPDETSKS 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	104/398 (26%)
		WD40	14..349	CDD:238121	99/375 (26%)
		WD40 repeat	16..68	CDD:293791	9/55 (16%)
		WD40 repeat	74..127	CDD:293791	20/56 (36%)
		WD40 repeat	132..169	CDD:293791	14/36 (39%)
		WD40 repeat	176..211	CDD:293791	12/34 (35%)
		WD40 repeat	223..263	CDD:293791	14/43 (33%)
		WD40 repeat	275..322	CDD:293791	11/53 (21%)
		WD40 repeat	328..350	CDD:293791	6/21 (29%)
		HIRA_B	423..442	CDD:286531	4/20 (20%)
		Hira	629..820	CDD:284895
Chaf1b	NP_001019912.1	WD40	12..387	CDD:225201	100/387 (26%)
		WD40	<13..251	CDD:295369	71/246 (29%)
		WD40 repeat	16..64	CDD:293791	9/55 (16%)
		WD40 repeat	70..127	CDD:293791	20/56 (36%)
		WD40 repeat	132..168	CDD:293791	14/36 (39%)
		WD40 repeat	175..230	CDD:293791	13/54 (24%)
		WD40 repeat	237..270	CDD:293791	11/32 (34%)
		WD40 repeat	278..311	CDD:293791	5/32 (16%)
		WD40	321..>400	CDD:295369	22/105 (21%)
		CAF-1_p60_C	388..561	CDD:292150	44/220 (20%)
		GSK-3_bind	<434..>546	CDD:283100	22/121 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920