DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and slm9

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_596243.1	Gene:	slm9 / 2540128	PomBaseID:	SPBC15D4.03	Length:	807	Species:	Schizosaccharomyces pombe

Alignment Length:	896	Identity:	196/896 - (21%)
Similarity:	320/896 - (35%)	Gaps:	257/896 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 VNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESW-KCFYTLRG--------H 128
            ::|:|::.:|..||..::                  .|....:.|.| |.|..|.|        .
pombe    67 ISCIRFTYDGSCLAVATE------------------AGTFLYHSEKWDKAFQVLSGPAYEVCWSQ 113

  Fly   129 DGDVLDLAWSPNDVYL----------------ASCSIDNTVIIWDAQAFPHS-----------VA 166
            .|.:|..:|....:|:                |..:....|.|.:::....|           :.
pombe   114 QGHILATSWKQISIYVKDEGLRTETIVKKTEHADSNHQPAVSIEESKEAVESTSQSSEISFKLIK 178

  Fly   167 TLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPD 231
            .::||...|.|:::||:|:||||||.|.::|:|....:.:..:|.:|||:.......||||||||
pombe   179 VIEGHHTFVGGLAFDPMGQFLASQSFDHTLKVWKLSTFGVEKSIAKPFEQMPTGNRFLRLSWSPD 243

  Fly   232 GQYLVSAHAMNGGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCC 296
            |.::.|.:|:|.|.....|::|:.|..|.:.|||:..:.|..|:..:.         ..|.|...
pombe   244 GAHIASVNAVNEGAYVIAIVQRDTWTYDINLVGHQGPLECATFNPYLY---------EDPFQKSI 299

  Fly   297 LAVGSRDRSLSVWMTALQRPMVVIHELFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGK 361
            :|..:.|..:|:|.||..|||.|||||..:|.:||.|......|...|:||::..|:|.|.|.|
pombe   300 IASAAHDGCVSIWNTACARPMAVIHELSCSSFVDLQWSTSGFELYGVSLDGNLMLLQFEESEFG- 363

  Fly   362 AISEEEQNAIIRKMYGKNYVNGLGKSAPVLEHPQRLLLPQGDKPTKFPLSNNNEANQR---PISK 423
                 |:...|......:|.|.....|.|                     |.|.|..|   |...
pombe   364 -----EKMDTIHYPDDLSYFNSSRSKAHV---------------------NKNAAADRTTSPTQG 402

  Fly   424 QTETRTKDGKRRITPMFIPLHEDGPTSLSMNIVSSSGSSTTALTSCSAAIGTLPAAAPTESAATP 488
            |.|:.:|....|..|               :|.||..|..   ..|           |.:..|.|
pombe   403 QPESPSKSILLRPPP---------------SIASSPESKR---RKC-----------PKKFVARP 438

  Fly   489 LMPLEPLVSKIDLGRLDSRLKTQPASQRRQSLPFDPGQSNELLRTPRLEEHQS-STCSPSNLNVT 552
            .:| .|               |...||.|...|:         ..|:|...:| .|....|.|..
pombe   439 PVP-HP---------------TSLYSQIRIGCPY---------LKPKLVISKSFGTLIVKNHNQL 478

  Fly   553 ATGKSEFVKAALDYRLHVSNGHLKTQHGMLAKVTASDSKEMLWEFYVGSPLVNLNLCEKYAMLCS 617
            :..|..|           ||               .|..:..|..|:.:.:|..|....:..:.:
pombe   479 SLLKCTF-----------SN---------------LDGNDCSWFSYLPNAIVLANGTSVFWAVAT 517

  Fly   618 LDGSMRLISMETGCPVFPAISLTSSAVHCAFSPDNSLVGVLTECGLLRIWDIAK-KVVSLAAGCL 681
            .|.|:.:.| ..|..:.|.:.:  :|..|........:..:...|||.||:|.. :.:......|
pombe   518 EDSSIYIYS-PAGRLLLPPVVV--AATPCFLECCGDFLCCIVSTGLLYIWNIKNFEAIHSPVSTL 579

  Fly   682 ELLNKHGTAA---------QFSVTNQGMPLIGFPSGNSYSYSTSLQSWLVLATKDAIMYHGIRGT 737
            .|.:.:.:.:         ||.||.||.|:.....||::::.....|||
pombe   580 PLFHSNFSVSKIARGPSIEQFFVTKQGHPVAIMSDGNAFAFIRDSSSWL---------------- 628

  Fly   738 LPRDMDQMQQKFPLLSMQ-----ASSQNYFSFTGSMELRHSESWQQCAKIRFIENQIKLCEALQS 797
                  ::.:.:.::..|     ||..|..|..|.:|....|...:..:.||::..:|.....|.
pombe   629 ------RVSEGWWMIGSQYWGPLASESNEESPLGFLERCTDEEIIKAGRGRFLQRLVKALMLRQG 687

  Fly   798 LD------ELQHWHKML-------------------TFQLATHGSEKRMRVFLDDLLS---MPEP 834
            .|      .::|....|                   ..::|..|.:.:|.....:||.   :|..
pombe   688 YDNYEMLVSIRHLENRLMSSAKLDLEYDFRENLILYAKKIAEEGMKDKMDELCKELLGPLRIPHN 752

  Fly   835 GISQ-------FVPKLE-------LMQCVLDTLKPHSEWNRLHSEYTELLK 871
            ||..       :.|.:.       |...::.|.| :.:..|:.|:|::||:
pombe   753 GIDTVKVGNRLWSPTIAGNNKRNLLKDIIIHTAK-YRDMQRITSQYSDLLR 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	92/332 (28%)
		WD40	14..349	CDD:238121	86/311 (28%)
		WD40 repeat	16..68	CDD:293791
		WD40 repeat	74..127	CDD:293791	11/53 (21%)
		WD40 repeat	132..169	CDD:293791	7/63 (11%)
		WD40 repeat	176..211	CDD:293791	13/34 (38%)
		WD40 repeat	223..263	CDD:293791	17/39 (44%)
		WD40 repeat	275..322	CDD:293791	13/46 (28%)
		WD40 repeat	328..350	CDD:293791	7/21 (33%)
		HIRA_B	423..442	CDD:286531	5/18 (28%)
		Hira	629..820	CDD:284895	41/230 (18%)
slm9	NP_596243.1	WD40	43..>396	CDD:225201	100/382 (26%)
		WD40	50..354	CDD:295369	86/313 (27%)
		WD40 repeat	107..147	CDD:293791	4/39 (10%)
		WD40 repeat	188..225	CDD:293791	14/36 (39%)
		WD40 repeat	235..275	CDD:293791	17/39 (44%)
		WD40 repeat	281..325	CDD:293791	15/52 (29%)
		Hira	528..735	CDD:284895	41/230 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0973
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003162
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13831
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.960