DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hira and Nle1

DIOPT Version :9

Sequence 1:NP_572401.2 Gene:Hira / 31680 FlyBaseID:FBgn0022786 Length:1047 Species:Drosophila melanogaster
Sequence 2:NP_663406.2 Gene:Nle1 / 217011 MGIID:2429770 Length:485 Species:Mus musculus


Alignment Length:531 Identity:119/531 - (22%)
Similarity:184/531 - (34%) Gaps:180/531 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 VPKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFY 123
            |.:....::.|...|..|.:|..|:.|||||.|..:..|..|.           :..|      :
Mouse   103 VTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST-----------ETPH------F 150

  Fly   124 TLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLG---- 184
            |.:||...||.::|||:...|||...:..|::||.........||.||:..:.|:||:||.    
Mouse   151 TCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSWEPLHMNPE 215

  Fly   185 -RFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTA 248
             |::||.|.|.|:::|:|                                             ||
Mouse   216 CRYVASSSKDGSVRVWDT---------------------------------------------TA 235

  Fly   249 QIIEREGWKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVWMT-- 311
                   .:|::...||.::|||:|:        ..||         .|...|:||::.||..  
Mouse   236 -------GRCERILTGHTQSVTCLRW--------GGDG---------LLYSASQDRTIKVWRAHD 276

  Fly   312 -ALQRPMVVIHELFNASILDLTWG-------PQECLLMACSVDGSIACLKFTEEELGKAISEEEQ 368
             .|.|.:.......|...|...:.       |.|..:.|..:.||:..||              :
Mouse   277 GVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEATVNAQDLQGSLKELK--------------E 327

  Fly   369 NAIIRKMYGKNYVNGLGKSAPVLEHPQRLLLPQGDKPTKFPLSNNNEA-NQRPISKQTETRTKDG 432
            .|..|    .|.|.|.|        |:||:....|    |.|...:.| :::|:::.|       
Mouse   328 RASSR----YNLVRGQG--------PERLVSGSDD----FTLFLWSPAEDKKPLARMT------- 369

  Fly   433 KRRITPMFIPLHEDGPTSLSMNIVSSSGSSTTALTSCSAAI-------GTLPAAAPTESAATPLM 490
                          |..:|...::.|..|...|..|...:|       |...|:.....||...:
Mouse   370 --------------GHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQI 420

  Fly   491 PLEP----LVSKIDLGRLDSRLKTQPASQRRQSLPFD-PGQSNELLRTPRLEEHQSSTCSPSNLN 550
            ....    |||    |..||.||....  :.|.|..| ||.::|:         .:...||....
Mouse   421 AWSADSRLLVS----GSSDSTLKVWDV--KAQKLATDLPGHADEV---------YAVDWSPDGQR 470

  Fly   551 VTATGKSEFVK 561
            |.:.||.:.::
Mouse   471 VASGGKDKCLR 481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HiraNP_572401.2 WD40 <12..370 CDD:225201 74/325 (23%)
WD40 14..349 CDD:238121 71/304 (23%)
WD40 repeat 16..68 CDD:293791 1/8 (13%)
WD40 repeat 74..127 CDD:293791 13/52 (25%)
WD40 repeat 132..169 CDD:293791 12/36 (33%)
WD40 repeat 176..211 CDD:293791 13/39 (33%)
WD40 repeat 223..263 CDD:293791 3/39 (8%)
WD40 repeat 275..322 CDD:293791 10/49 (20%)
WD40 repeat 328..350 CDD:293791 6/28 (21%)
HIRA_B 423..442 CDD:286531 1/18 (6%)
Hira 629..820 CDD:284895
Nle1NP_663406.2 NLE 17..77 CDD:285380
WD40 106..484 CDD:238121 118/528 (22%)
WD40 107..485 CDD:225201 118/527 (22%)
WD 1 112..151 14/55 (25%)
WD 2 154..193 13/38 (34%)
WD40 repeat 159..197 CDD:293791 13/37 (35%)
WD 3 197..241 18/95 (19%)
WD40 repeat 203..244 CDD:293791 16/92 (17%)
WD 4 244..282 15/54 (28%)
WD40 repeat 249..284 CDD:293791 14/51 (27%)
WD40 repeat 291..369 CDD:293791 23/107 (21%)
WD 5 327..366 14/54 (26%)
WD 6 370..409 8/38 (21%)
WD40 repeat 375..411 CDD:293791 7/35 (20%)
WD 7 412..451 12/44 (27%)
WD40 repeat 417..453 CDD:293791 11/41 (27%)
WD 8 454..484 7/37 (19%)
WD40 repeat 459..483 CDD:293791 5/32 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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