DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and lis-1

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_499755.1	Gene:	lis-1 / 176758	WormBaseID:	WBGene00003047	Length:	404	Species:	Caenorhabditis elegans

Alignment Length:	327	Identity:	81/327 - (24%)
Similarity:	119/327 - (36%)	Gaps:	92/327 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RVV---IWNLLPVLSDKAE---FDADVPKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIW 97
            ||:   :|.::...|:.|.   :|.:..::...:..|...||.:.....|:.|.|.|.|..|.:|
Worm   111 RVIFHPLWTIMASCSEDATIKVWDYETGQLERTLKGHTDAVNDIAIDAAGKQLVSCSSDLSIKLW 175

  Fly    98 ---------------RKSAGSSGVFGTG----GMQKNH--ESWK-----CFYTLRGHDGDVLDLA 136
                           ..:..|.....||    ...::|  :.|.     |.||.|||:..|..:.
Worm   176 DFGQTYDCLKSLKGHEHTVSSVTFLPTGDFVLSASRDHTIKQWDISTGYCVYTFRGHNDWVRMIR 240

  Fly   137 WSPNDVYLASCSIDNTVIIWDAQAFPHSVAT------LKGHTGLVKGVSWDP-------LGR--- 185
            .|.:....||.|:|.||.:|       |.||      |:.|...|:.|.|.|       .|:
Worm   241 ISNDGTLFASASLDQTVTVW-------SFATKSAKLVLRDHEHAVECVEWAPDTAYTNVTGQQPE 298

  Fly   186 -----FLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTH---ILRLSWSPDGQYLVSAHAMN 242
                 .|.|.|.|||||.||.....:..|:         ..|   :..|::.|.|:||:|.
Worm   299 GNSTHILFSGSRDRSIKAWNINTGDVLFTL---------LAHENWVRGLAFHPKGKYLISV---- 350

  Fly   243 GGGPTAQIIEREGWKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLS 307
            ....|.::.|....:|.|....|...|:.|.||.:         ||       .:..||.|.|..
Worm   351 ADDKTLRVWELSAQRCMKAIEAHEHFVSTVAFHQT---------SP-------FVITGSVDMSCK 399

  Fly   308 VW 309
            ||
Worm   400 VW 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	81/327 (25%)
		WD40	14..349	CDD:238121	81/327 (25%)
		WD40 repeat	16..68	CDD:293791	6/34 (18%)
		WD40 repeat	74..127	CDD:293791	16/78 (21%)
		WD40 repeat	132..169	CDD:293791	12/42 (29%)
		WD40 repeat	176..211	CDD:293791	15/49 (31%)
		WD40 repeat	223..263	CDD:293791	10/39 (26%)
		WD40 repeat	275..322	CDD:293791	9/35 (26%)
		WD40 repeat	328..350	CDD:293791
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
lis-1	NP_499755.1	LisH	7..39	CDD:128913
		WD40	98..402	CDD:238121	81/327 (25%)
		WD40	<100..404	CDD:225201	81/327 (25%)
		WD40 repeat	109..146	CDD:293791	6/34 (18%)
		WD40 repeat	152..189	CDD:293791	8/36 (22%)
		WD40 repeat	194..230	CDD:293791	8/35 (23%)
		WD40 repeat	237..272	CDD:293791	11/41 (27%)
		WD40 repeat	278..329	CDD:293791	16/59 (27%)
		WD40 repeat	335..371	CDD:293791	10/39 (26%)
		WD40 repeat	377..401	CDD:293791	10/39 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910