DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and hira-1

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_498101.2	Gene:	hira-1 / 175709	WormBaseID:	WBGene00019627	Length:	935	Species:	Caenorhabditis elegans

Alignment Length:	1052	Identity:	289/1052 - (27%)
Similarity:	443/1052 - (42%)	Gaps:	253/1052 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PAWVHHDDKQIFSVDIHKDCTKFATGGQ--GSDCGRVVIWNLLPVLSDKAEFDADVPKMLCQMDQ 68
            |.:|.||...|.::|.|....||.|.||  .:..|.||:||..|||..|...:.:|||:|.|::.
Worm     9 PTFVGHDTGSILAIDCHPSGKKFITCGQKARTSNGLVVVWNAEPVLDKKKASNENVPKLLFQVES 73

  Fly    69 HLACVNCVRWSQNGQNLASGSDDKLIMIWR-----KSAGSSGVFGTGGMQKNHESWKCFYTLRGH 128
            .....:| |||.:|:..|.||||..:.:|.     .|.||.    |||.| |.|.:|....||||
Worm    74 QSQSNSC-RWSPDGKRFAFGSDDSSVSVWEYVGLINSMGSI----TGGAQ-NVERYKECCVLRGH 132

  Fly   129 DGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDD 193
            ..:||.:.||||..||||.|||..:||::|:..|..:..|......|||:||||:|::|||...|
Worm   133 SMEVLTVEWSPNGKYLASGSIDYRIIIYNARKLPDRITVLNDIQLPVKGLSWDPIGKYLASLEGD 197

  Fly   194 RSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKC 258
            :.::.|.|.:|....::|||||.....|.:.||.|||||:||::..|:..|.|..::|:|:.||.
Worm   198 KKLRFWATDSWQCVKSVTEPFESNIEETMLTRLDWSPDGKYLMTPAAVRSGKPLIKLIQRQTWKS 262

  Fly   259 DKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVWM-TALQRPMVVIHE 322
            |:...||.|..||||....::.....:|   |.:|..|.||||||:|:|:|: ....:|:.||:.
Worm   263 DQFLAGHHKGTTCVRAMPRLIEANLKNG---KRMQLTCAAVGSRDKSISIWVFPGTLKPLFVINN 324

  Fly   323 LFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEEQNAIIRKMYG---KNY---- 380
            :||.:::|..|..:.  |:|||.||::..:..:|..:|:.||.|..:.:..::|.   ..|
Worm   325 IFNHTVMDFAWCGRN--LLACSQDGTVKVIHLSESVIGEMISNEAMSDLCYQIYSIRPPRYELTD 387

  Fly   381 -----------VNGLGKSA----------PVLEHPQRLLLPQ--GDKPTKFPLSNNNEANQRPIS 422
                       ::.|..||          .||...::|:..|  .|......:.:|::.|:...|
Worm   388 KEEDESQDSFNLSDLSSSANNASFVTCPEDVLIKRKKLVAAQQSSDIQLTKSMEDNSKENESKNS 452

  Fly   423 KQT--ETRT------KDGKRRITPMFIPLHEDGPTSLS-MNIVSSSGSSTTALTSCSAAIGTLPA 478
            ::|  |.|.      |||||||.|:|.     |.|:.. |..:||.|..|.|......     .|
Worm   453 EKTMMEERNKQIDVRKDGKRRIQPVFC-----GTTTADPMTSLSSEGKKTVAPPPAKR-----KA 507

  Fly   479 AAPTESAATPLMPLEPL---------------VSKIDLGRLDSRLKTQPASQRRQSL-------- 520
            .||...|....:.||..               :|.|:..|...|......||...:|
Worm   508 LAPAVPAKKGEVDLEDSSDSDDDDEEEEEDMEISDIESVRNKKRKVPATTSQPMLALDLKKPALR 572

  Fly   521 PFDP----GQSNELL-----RTPRLEEHQSSTCSPSNLNVTATGKSEFVKAALDYRLHVSNGHLK 576
            |.:|    .|...:|     :.|:|.:|            ....|..||:  :|.|.  .:|.::
Worm   573 PMEPKSLKTQEGTVLMEAPEQQPKLSQH------------VVDRKGMFVE--IDNRW--KHGGVE 621

  Fly   577 TQHGMLAK---VTASDSKEM-----------LWEFYVGSPLV-------NLNL-----CEK-YAM 614
            |....|.|   .||.:..:|           ||...:|||::       |:.|     |.: |..
Worm   622 TTQIKLIKKKQQTAENEDDMMDGERRVNHECLWMAVLGSPVIIVAANKHNVVLGCGDKCLRVYRT 686

  Fly   615 LCSLD-GSMRLISMETGCPVFPAISLTSSAVHCAFSPDNSLVGVLTECGLLRIWD--IAKKVVSL 676
            .|... .|:||.|:    ||.  |.:|.   |.|::        |||.|.|..|:  :.|.||:.
Worm   687 FCGTHIVSLRLDSL----PVL--IGVTE---HAAYA--------LTENGRLSTWNLKLGKAVVTR 734

  Fly   677 AA--GCLELLNKHGTAAQFSVTNQGMPLIGFPSGNSYSYSTSLQSWLVLATKDAIMYHGIRGTLP 739
            ..  .|:| .:...:.....|:..|:|||.|.:|:.::::.||..|:...|.:.:      |.|.
Worm   735 QPLFDCVE-ASTDNSLISADVSETGVPLIVFSNGSIFTFNVSLSCWIQAITTNVL------GRLT 792

  Fly   740 RDMDQMQQKFPLLSMQASSQNYFSFTGSMELRHSESWQQCAKIRFIENQI----------KLCEA 794
            .         |:...|.|..|..:.:....:|..:..::.|....:..|:          :|...
Worm   793 S---------PISDAQLSCSNGTTNSAGPLVRLLKRMRKQATAPGVAPQVVKAVKESQLEQLLHC 848

  Fly   795 LQSLDELQHWHKMLTFQLAT---HGSEKRMRVFLDDLLSMPEPGISQFVPKLELMQCVLDTLKPH 856
            .:.|...|.:..||...:.|   .||||:::..|:||.....|          :..|.|
Worm   849 AEQLGNPQDYQTMLMLYVETLCEGGSEKKLKNILNDLSRSGAP----------MQVCGL------ 897

  Fly   857 SEWNRLHSEYTELLKECKSERQKDIFATPAPPQQKTASSAGSSPRSGEATGEEVTEKDGATAVAA 921
             ..:.|:.:.|.::|          ...|                                |:||
Worm   898 -RRSALYDDVTRMIK----------LKQP--------------------------------AIAA 919

  Fly   922 AVVAGSRMAVTT 933
            .:|||...:.||
Worm   920 RIVAGVAASTTT 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	142/365 (39%)
		WD40	14..349	CDD:238121	136/342 (40%)
		WD40 repeat	16..68	CDD:293791	22/53 (42%)
		WD40 repeat	74..127	CDD:293791	22/57 (39%)
		WD40 repeat	132..169	CDD:293791	17/36 (47%)
		WD40 repeat	176..211	CDD:293791	14/34 (41%)
		WD40 repeat	223..263	CDD:293791	17/39 (44%)
		WD40 repeat	275..322	CDD:293791	16/47 (34%)
		WD40 repeat	328..350	CDD:293791	8/21 (38%)
		HIRA_B	423..442	CDD:286531	12/26 (46%)
		Hira	629..820	CDD:284895	46/207 (22%)
hira-1	NP_498101.2	WD40	<10..359	CDD:225201	140/359 (39%)
		WD40	10..351	CDD:295369	139/351 (40%)
		WD40 repeat	19..71	CDD:293791	21/51 (41%)
		WD40 repeat	79..131	CDD:293791	22/57 (39%)
		WD40 repeat	137..174	CDD:293791	17/36 (47%)
		WD40 repeat	179..219	CDD:293791	18/39 (46%)
		WD40 repeat	227..267	CDD:293791	17/39 (44%)
		WD40 repeat	274..321	CDD:293791	18/49 (37%)
		Hira	688..877	CDD:284895	51/221 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162237
Domainoid	1	1.000	49	1.000	Domainoid score	I7990
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48172
Inparanoid	1	1.050	288	1.000	Inparanoid score	I1709
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28795
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	1	1.000	-	-		FOG0003162
OrthoInspector	1	1.000	-	-		oto18916
orthoMCL	1	0.900	-	-		OOG6_103167
Panther	1	1.100	-	-	LDO	PTHR13831
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R561
SonicParanoid	1	1.000	-	-		X3052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940