DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hira and wdr-5.1

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_497749.1	Gene:	wdr-5.1 / 175474	WormBaseID:	WBGene00006474	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	296	Identity:	70/296 - (23%)
Similarity:	123/296 - (41%)	Gaps:	66/296 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TKFATGGQGSDCGR----------VVIWNLLPVLSDKAEFDADVPKMLCQ--MDQHLACVNCVRW 78
            ||..:..:.|.||:          |.|||:              ..|:|:  :..|...||.:.|
Worm    87 TKSISSAKFSPCGKYLGTSSADKTVKIWNM--------------DHMICERTLTGHKLGVNDIAW 137

  Fly    79 SQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVY 143
            |.:.:.:.|.||||.:.|:.        ..|..|.|         ||:||:..|....::|....
Worm   138 SSDSRCVVSASDDKTLKIFE--------IVTSRMTK---------TLKGHNNYVFCCNFNPQSSL 185

  Fly   144 LASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSH 208
            :.|.|.|.:|.|||.:. ...:.||..|:..|..||::..|..:||.|.|..::||:|.|.....
Worm   186 VVSGSFDESVRIWDVKT-GMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCIK 249

  Fly   209 TITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDKDFVGHRKAVTCVR 273
            |:.:  :|   ...:..:.:||:|:|:::::.    ..|.::.:....|..|.:.||..:..|:.
Worm   250 TLVD--DE---NPPVAFVKFSPNGKYILASNL----DSTLKLWDFSKGKTLKQYTGHENSKYCIF 305

  Fly   274 FHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVW 309
            .:.|:...:             .:..||.|..:.:|
Worm   306 ANFSVTGGK-------------WIISGSEDCKIYIW 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	70/296 (24%)
		WD40	14..349	CDD:238121	70/296 (24%)
		WD40 repeat	16..68	CDD:293791	11/53 (21%)
		WD40 repeat	74..127	CDD:293791	14/52 (27%)
		WD40 repeat	132..169	CDD:293791	10/36 (28%)
		WD40 repeat	176..211	CDD:293791	12/34 (35%)
		WD40 repeat	223..263	CDD:293791	7/39 (18%)
		WD40 repeat	275..322	CDD:293791	5/35 (14%)
		WD40 repeat	328..350	CDD:293791
		HIRA_B	423..442	CDD:286531
		Hira	629..820	CDD:284895
wdr-5.1	NP_497749.1	WD40	<76..372	CDD:225201	70/296 (24%)
		WD40	79..373	CDD:238121	70/296 (24%)
		WD40 repeat	90..127	CDD:293791	9/50 (18%)
		WD40 repeat	133..169	CDD:293791	14/52 (27%)
		WD40 repeat	174..210	CDD:293791	10/36 (28%)
		WD40 repeat	217..252	CDD:293791	12/34 (35%)
		WD40 repeat	259..295	CDD:293791	7/39 (18%)
		WD40 repeat	303..340	CDD:293791	6/39 (15%)
		WD40 repeat	346..372	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910